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WASHINGTON, Nov. 7 (Xinhua) -- U.S. researchers have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.The findings, published Monday in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes."The brain is the body's only organ that needs a constant supply of glucose to survive, so it makes sense that it would have some say over how much glucose is produced," said study leader Meredith Hawkins, professor of medicine and director of the Global Diabetes Initiative at Yeshiva University, in a statement. "This role for the brain was demonstrated in earlier studies in rodents, but there was considerable controversy over whether the results could be applied to humans. We hope this study helps to settle the matter."In an earlier study in rodents, researchers showed that activation of potassium channels in the brain's hypothalamus sends signals to the liver that dampen its production of glucose. Those findings, published in Nature in 2005, challenged the conventional thinking that blood sugar production by the liver (the body's glucose factory) is regulated only by the pancreas (which makes insulin to metabolize glucose). But carefully performed studies on dogs, conducted at Vanderbilt University, failed to replicate the results, suggesting the Einstein findings in rodents might not be relevant to higher mammals, including humans.The current study, involving people, was aimed at resolving this controversy. Ten nondiabetic subjects were given oral diazoxide, a drug that activates potassium channels in the hypothalamus. (The drug is not used to treat diabetes.) Hormone secretion by the pancreas was controlled to ensure that any change in sugar production would only have occurred through the drug's effect on the brain. After the researchers administered the drug, blood tests revealed that patients' livers were producing significantly less glucose than before.Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results. They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus. Additional experiments confirmed that diazoxide was working through the brain. Specifically, the researchers were able to completely block the effects of diazoxide by infusing a specific potassium channel blocker directly into the brain."This study confirms that the brain plays a significant role in regulating glucose production by the liver," said lead author Preeti Kishore, assistant professor of medicine. "We are now investigating whether this 'brain-to-liver' pathway is impaired in people with diabetes. If so, we may be able to restore normal glucose regulation by targeting potassium channels in the brain."

SAN FRANCISCO, Nov. 7 (Xinhua) -- Google on Monday added a highly-anticipated service to its Google+ social network, allowing businesses and brands to set up their own pages on the site.Named "Google+ Page," the service is a further challenge to its rival Facebook's fan pages, which has become a major promotion strategy for many business brands over the past several years.Unlike Facebook, Google will not charge businesses and organizations for using the scheme, and will not put ads on the pages. The service is expected to enhance the tech giant's other businesses like search and mobile advertising.Some big brand names, such as Burberry, the Barcelona football club and the Muppets, have already set up their pages.Google noted it will not pass on personal data.In addition to big brands, Google also wants small businesses that have or do not have their own websites to use Google+ Pages as their default presences.According to a report by Ad Age Digital, Google+ Pages will soon be location-aware, allowing local businesses to send offers and deals to mobile phones.According to Google, more than 40 million people have opened an account with its social network, which was launched in June. Although the network is growing very quickly, some analysts said it still has a long way to go to become a major threat to Facebook, which has more than 800 million users.
LAS VEGAS, the United States, Jan. 12 (Xinhua) -- NVIDIA, the computer chip manufacturer best known for its high performance graphics processors, is looking to make further inroads with the automobile industry by integrating its new Tegra 3 mobile processors in upcoming vehicle models.At the 2012 International Consumer Electronics Show (CES), NVIDIA and Audi announced that all models from the German auto manufacturer in 2013 will use Tegra 3 quad-core processors to power their in-car digital systems.These processors, which are traditionally found in smartphones and tablets, will support the vehicle's digital systems at lower energy rates and also allow for shorter lead times in getting concepts to market.In addition to powering infotainment systems that allow for web browsing and Google Earth integrations, they will also give automakers the ability to replace traditional dashboards with instrument cluster systems, or digital dashboards."By leveraging technology from the very latest smartphones and tablets, Audi is leading the market with innovations that enhance safety and make driving more enjoyable," said Ricky Hudi, the company's chief executive engineer, at Audi's official conference at CES.For Audi, this means that they will be able to offer cars like the next-generation A3 model beginning in 2013, which features an integrated touchpad system and mounted monitor with the ability to render 3D imaging. Current 2012 Audi vehicles house the Tegra 2 processor."It's a natural progression with people getting so accustomed to mobile and expecting it from your automobiles as well. Partnering really closely with automotive OEMs enable us to help them realize the driver experience they're looking to deliver," said Phillip Hughes, NVIDIA's director of automotive sales and business development, in an interview with Xinhua.In addition to Audi, Tesla and Lamborghini will also be including the newest NVIDIA Tegra 3 processor in upcoming models. At this year's CES, Lamborghini is showcasing the Lamborghini Aventador, a nearly 700 horsepower vehicle with the capability of going from 0 to 60 miles per mile in less than five seconds."NVIDIA technology is enabling us to do more with our vehicles and gives our cars the ability to have the technology you'd expect from a car like this," said Kelly Snyder, an event manager with Lamborghini, to Xinhua. The retail price point for the Lamborghini Aventador starts at 382,000 U.S. dollars.More than just powering the car's digital experiences, however, integrating NVIDIA's processors will help the auto manufacturer build better cars by reducing the power to weight ratio that is a key consideration in manufacturing higher performing cars."By moving elements like the odometer to a digital dashboard platform, it reduces the power to weight ratio that is so critical to the design and manufacturing of automobiles like the Lamborghini," explained Snyder.NVIDIA also expects that the integration of these processors will bring the development cycle of the automotive industry up to speed with the consumer electronics industry through Virtual Computing Modules (VCMs) powered by the Tegra 3. These VCMs allow auto manufacturers to quickly prototype and ship consumer technology innovations to automobiles, reducing a development lifecycle that once took seven years, to roughly a year."At the end of the day, our goal is to help automotive OEMs bridge the gap between OEM and consumer technology," said Hughes.
KATHMANDU, Oct. 30 (Xinhua) -- "One of the major problems of death due to breast cancer in Nepal is poverty and untimely diagnosis," said Dr. Abish Adhikari Oncologist at the Bir Hospital in Nepali capital Kathmandu in an exclusive interview with Xinhua on Sunday.Adhikari said that the other reason why breast cancer leads to death of women is "women are not decision makers in their houses"."Many people who come here do not want to treat their wives or daughters because of the expenses as they are poor and it is really expensive here to treat cancer," Adhikari said.According to the Nepal Cancer Relief Society, of all cancer cases among the Nepali women and teenage girls as well, 60 percent is of breast cancer.Unverified rough data of the breast cancer patients in Nepal are above 50,000.Adhikari added that women are shy to talk about the problems of breast. They do not go to hospitals for the check up until they are bedridden and at the time they reach hospital they are mostly in the advanced stage.The major causes behind the breast cancer in Nepal are heredity, late pregnancy, consumption of alcohol and smoking. However, unawareness about it remains another major problem that leadind to death of many women in Nepal.Moreover, the rural women in Nepal are unaware about breast cancer, and if they are having some problem, they tend to hide it.Talking to Xinhua, Sajani Manandhar, General Secretary of Richa Bajimaya Memorial Foundation, a cancer awareness raising group said that the major cause of the preventable cancer in Nepal is unawareness.Also a nurse by profession, she said that no one bothers about mammography or regular checkup but are diagnosed at the very late stage.There are less than five hospitals that provide mammography service in the country.Roshani Chitrakar, 48 who is in advanced stage of cancer said that she did not told anyone while she found something unusual in her breast because it was not painful."I took it normally, but when I thought it might be a cancer and told my family and I was already in the advanced stage," she said.Her daughter, Roji Manandhar, said that the doctor has already told that she will not be living long. She is having difficulty even to eat currently.Another cancer patient, 67 years old farmer, Nakkali Nahakhusi said that she told her husband when she found her breast unusual. Her husband, former armyman, immediately took her to the hospital when she told about the problem.Now, she is already cured, and said with smilingly that the god of death did not want to take me away.She said that awareness should be raised because cancer is curable at the early stage.
来源:资阳报