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If Halloween is your excuse for endlessly indulging in candy (and of course it is), go slow on the black licorice.Just as it does each Halloween, the Food and Drug Administration has posted a reminder on its website urging folks to keep their black licorice consumption to a minimum.The reasoning? Too much of the old-fashioned favorite can cause health problems such as irregular heart rhythm, especially in people over 40.Black licorice contains a sweetening compound called glycyrrhizin, which can cause a drop in potassium levels. With low levels, some people might experience high blood pressure, swelling and even congestive heart failure, the FDA says.The good news is that potassium levels return to normal after you stop eating copious amounts of black licorice.So, here are some tips from the FDA:-- Don't eat too much of the stuff at one go.-- If you have been eating a lot of it, especially if you have irregular heart rhythm or muscle weakness, stop (and call your doctor). 994
How accurate are the coronavirus tests used in the U.S.?Months into the outbreak, no one really knows how well many of the screening tests work, and experts at top medical centers say it is time to do the studies to find out.When the new virus began spreading, the Food and Drug Administration used its emergency powers to OK scores of quickly devised tests, based mainly on a small number of lab studies showing they could successfully detect the virus.That’s very different from the large patient studies that can take weeks or months, which experts say are needed to provide a true sense of testing accuracy.The FDA’s speedy response came after it was initially criticized for delaying the launch of new tests during a crisis and after the Centers for Disease Control and Prevention stumbled in getting its own test out to states.But with the U.S. outbreak nearly certain to stretch on for months or even years, some experts want the FDA to demand better evidence of the tests’ accuracy so doctors know how many infections might be missed.There have been more than 2 million confirmed coronavirus cases in the U.S. and more than 115,000 deaths, according to data compiled by Johns Hopkins University. Cases in nearly half of U.S. states are rising.In recent weeks, preliminary findings have flagged potential problems with some COVID-19 tests, including one used daily at the White House. Faulty tests could leave many thousands of Americans with the incorrect assumption that they are virus-free, contributing to new flare-ups of the disease as communities reopen.“In the beginning, the FDA was under a lot of pressure to get these tests onto the marketplace,” said Dr. Steven Woloshin of Dartmouth College, who wrote about the issue in the New England Journal of Medicine last week. “But now that there are plenty of tests out there, it’s time for them to raise the bar.”The FDA said in a statement that it has already asked multiple test makers to do follow-up accuracy studies, although it didn’t say for how many of the more than 110 authorized screening tests. The agency also said it is tracking reports of problems. Accuracy has also been an issue with blood tests that look for signs of past infections.No screening test is 100% accurate. So details on accuracy are routinely provided for tests of all types, including seasonal flu, hepatitis, HIV and cancers. For example, rapid flu tests are known to miss 20% or more of all cases, a factor doctors weigh when treating patients who have symptoms but test negative.For now, most COVID-19 tests in the U.S. don’t give data on real-world performance, including how often the tests falsely clear patients of infection or falsely detect the virus. That information is lacking for all but a few of the roughly 80 commercial screening tests available, according to an Associated Press review.The government’s emergency authorization process “requires a lower level of evidence,” the agency said. Makers need only show that a test “may be effective” instead of the usual requirement to demonstrate “safety and effectiveness.” They would have to meet that higher threshold once the U.S. government declares the emergency over.Many of the commercial test makers submitted results from 60 samples, the minimum number required and mostly used lab-produced specimens of the virus. The FDA now recommends the use of nasal swabs or other real samples from people screened for coronavirus.Experts say larger patient studies patients are needed to assess a test’s true performance.Lab testing bears little resemblance to actual — sometimes imperfect — conditions at hospitals, clinics and testing sites noted Dr. Robert Kaplan of Stanford University.“You’re testing people in parking lots, the patients themselves are extremely anxious and often unable to follow instructions,” said Kaplan, a former associate director of the National Institutes of Health.Kaplan and others say those differences could explain why some tests are not performing as expected.Last month, the FDA warned doctors of a potential accuracy problem with Abbott Laboratories’ rapid ID Now test, which delivers results in roughly 15 minutes. The test has been lauded by President Donald Trump and used to screen the president, his staff and visitors to the White House.The FDA alert followed a preliminary report by New York University that found Abbott’s test missed between a third to one-half of infections caught by a rival test in patients screened for the virus.Abbott rejected the findings, saying the researchers did not follow the instructions for using its test. The company pointed to alternate patient studies, including its own, that have found the test successfully detects between 91% and 95% or more of virus cases when compared to other tests.But similar problems with ID NOW’s accuracy have been flagged in preliminary reports by researchers at Stanford University, Loyola University and the Cleveland Clinic.For now, the FDA is requiring Abbott to conduct follow-up studies in several different patient groups.The FDA’s emergency standards “are still high but there is a significant difference in the body of work that what would go into a submission under the normal process,” said Abbott vice president John Hackett. “Our normal process takes years to bring these out.”Requiring bigger studies of all coronavirus tests could provide valuable information, but it could also strain the FDA’s already stretched staff and resources, said Dr. Daniel Schultz, former director of the FDA’s medical device center.Dr. Colin West of the Mayo Clinic worries doctors and patients have put too much confidence in the current crop of tests, when an unknown number of patients with COVID-19 are likely receiving false negative results.Even a modest error rate can have grave consequences during an outbreak like COVID-19. West gives the example of a test that is 95% accurate at detecting the virus and is used on 1 million people. That would still result in 50,000 people being incorrectly told that they don’t have the virus.“The negative test does not mean that I’m off the hook,” West said. “We just need to maintain that level of vigilance until we have a better sense of how good these tests really can be.”___Follow Matthew Perrone on Twitter: @AP_FDAwriter.___Follow AP pandemic coverage at http://apnews.com/VirusOutbreak and https://apnews.com/UnderstandingtheOutbreak.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 6604

IMPERIAL BEACH, Calif. (KGTV) - Imperial Beach residents are being told by city officials to clean up - or pay up.Some 20 homeowners received a code enforcement letter last month indicating they needed to remove debris from their backyards.The letter read in part: 272
IMPERIAL BEACH, Calif. (KGTV) -- Several people were taken into Border Patrol custody early Monday morning after a panga boat washed ashore in Imperial Beach.At around 3:30 a.m., Border Patrol agents and sheriff’s deputies were dispatched to an area near Seacoast Drive and Encanto Avenue after a panga boat was reportedly spotted on the beach.ABC 10News learned agents took about 20 people -- believed to be undocumented migrants -- into custody.Agents and deputies fanned out to search the area for more boat passengers, but there was no immediate word on additional arrests. 585
In a stunning announcement to those in preparing to embark into medical school, New York University announced it would offer free tuition to all NYU medical program students — current and future.The reveal came during NYU School of Medicine's annual "White Coat Ceremony," where each new student is presented with a white lab coat to mark the start of their medical education and training.The bold offering is available to all current and future students in NYU's MD degree program, "regardless of need or merit.""Thanks to the extraordinary generosity of our trustees, alumni, and friends, our hope — and expectation — is that by making medical school accessible to a broader range of applicants, we will be a catalyst for transforming medical education nationwide," Kenneth G. Langone, Chair of the Board of Trustees of NYU Langone Health, said.The annual tuition costs covered by the scholarship is about ,000.NYU's free tuition initiative began with an endowment. So far, the university has raised more than 0 million of the roughly 0 million needed to fund full-tuition scholarships for all medical students "in perpetuity," according to ABC News.Crushing college debt strikes medical students particularly hard.About 75 percent of all doctors in the U.S. graduated with debt in 2017, the university said. The average cost for a private medical school is about ,605 a year. The median debt of a graduating student comes out to more about 2,000, NYU says."We believe that with our tuition-free initiative, we have taken a necessary, rational step that addresses a critical need to train the most talented physicians, unencumbered by crushing debt," said Robert I. Grossman, the Saul J. Farber Dean of NYU School of Medicine. "We hope that many other academic medical centers will soon choose to join us on this path." 1874
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