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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) - San Diego lawmakers responded Friday to President Donald Trump’s comments about border wall construction and funding as the government shutdown stretched into day 13. Trump declared he could keep parts of the government closed for "months or even years" as he and Democratic leaders failed in a second closed-door meeting to resolve his demand for billions of dollars for a border wall with Mexico. “We did a lot of wall in San Diego,” Trump said at a White House news conference. “They wanted it very badly.” Trump cited concerns about the U.S.-Mexico border, including entry by terrorists, drug smuggling, and human trafficking. San Diego County’s congressional representatives emailed comments to 10News regarding the president’s statements. “San Diegans view our proximity to Mexico as an opportunity, not a threat, and we recently celebrated building a bridge between our two countries – not a wall – a bridge with adequate customs staffing so people can travel back and forth easily, and legally,” wrote Rep. Scott Peters. “San Diegans want smart, innovative border security – not the wasteful wall that President Trump wants to build as a monument to himself.” Congressman Duncan Hunter, San Diego County’s lone Republican representative, issued a statement through his public information officer. “Congressman Hunter believes President Trump needs to stand strong on the issue of border security and his description of it as a ‘national emergency’ means he has a firm grasp of its importance. A border barrier is absolutely necessary, some of which is already in existence which many in Congress initially supported. What the President is asking for in terms of funding is not unreasonable and holding Congress accountable is exactly what he was elected to do.” 10News is awaiting responses from Rep. Juan Vargas, whose district includes the South Bay, and Rep. Susan Davis.The Associated Press contributed to this report. 1957

SAN DIEGO (KGTV) - San Diego and National City Police detained three people and sought a fourth Friday at a South Bay home where a neighbor said shots were fired.The incident started Friday about 5 p.m. at Alpha and 47th streets in National City. A woman who lives near the home told 10News she heard gunfire. A 10News crew on the scene saw a man and woman leave the home with their hands raised. Police said three people were detained for questioning. Officers were searching for a fourth person in relation to the incident.There were no reports of injuries. 10News is monitoring breaking developments. 611

SAN DIEGO (KGTV) -- San Diego Police officers babysat for a man who needed to go to the hospital Friday night but didn't have anyone to watch his two young daughters. According to the department, officers received a radio call from a young father living in the Alpha apartments. The man reportedly told authorities he was in need of hospital care. “Unfortunately, he had no family or friends to help watch the girls,” the department said.After the man was taken to the hospital, two officers stayed behind to watch the 2-year-old and 4-year-old before taking them to the hospital where they were reunited with their dad.“Dad was emotional and grateful for the support. If someone needs help, we'll be there to respond,” the department continued in the Facebook post.No emergency is too small for our officers. They received a radio call of a young father living in the Alpha apartments...Posted by San Diego Police Department on Saturday, October 10, 2020 969

SAN DIEGO (KGTV) - Residents in a senior mobile home park in Oceanside are worried about speeding drivers after two ducks were hit and killed Wednesday. Neighbors told 10News a mom, dad and baby duck were crossing the road around 5 a.m. when a newspaper delivery driver ran them over.Several residents reported that the driver responsible delivers the San Diego Union-Tribune newspaper and regularly speeds on their narrow roads.The UT told 10News their carriers are employed by a separate company but issued the following statement: "We have learned that a carrier from an independent distributor, who delivers The San Diego Union-Tribune, may have been involved in an auto collision involving a family of ducks. Safety is a priority for us and we support safe and respectful work practices among the vendors with whom we do business. We share the concerns of the residents and encourage the distributor to review the incident and address any unsafe practices." 970