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LOS ANGELES, July 18 (Xinhua) -- At least 70 genetic mutations may be involved in the formation of colon cancer, far more than scientists previously thought, a new study suggests.The study by researchers at University of Texas (UT) Southwestern Medical Center contradicts previous thinking that only a few mutated genes may play a role in the development of colon cancer."The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.The new study identified 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor- suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.According to previous studies, there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.Current cancer treatments target just one or two known cancer- driver genes. While patients may get transient tumor burden reduction, almost universally tumor growth returns."Those numbers are dead wrong," Dr. Shay said, suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.The next step is further research to classify more accurately which genes drive cancer and which are merely passengers, the researchers said.Study findings were published in the July 2011 Cancer Research (Priority Reports).
BEIJING, Aug. 1 (Xinhua) -- The provinces of Guizhou and Hunan reported their lowest levels of precipitation since 1951 in July, the China Meteorological Administration (CMA) said on Monday.Precipitation levels across the country saw a decrease of 8.7 percent from the average level of 115.9 mm in July, the lowest levels seen in 11 years, said Chen Zhenlin, an expert with the CMA.The average temperature recorded across the country in July was 22.1 degrees Celsius, up 0.7 degrees Celsius from the average level.

WASHINGTON, July 5 (Xinhua) -- Adhering to a healthy lifestyle, including not smoking, exercising regularly, having a low body weight and eating a healthy diet, appears to lower the risk of sudden cardiac death (SCD) in women, according to a study to be published Wednesday in the Journal of the American Medical Association."Sudden cardiac death (defined as death occurring within one hour after symptom onset without evidence of circulatory collapse) accounts for more than half of all cardiac deaths, with an incidence of approximately 250,000 to 310,000 cases annually in the United States," the authors write as background information in the study.Using data collected as part of the Nurses' Health Study, Stephanie Chiuve, of Brigham and Women's Hospital and Harvard Medical School, and colleagues examined the association between a healthy lifestyle and risk of SCD.A total of 81,722 women who participated in the Nurses' Health Study from June 1984 to June 2010 were included in the new study, and lifestyle factors were assessed via questionnaires every two to four years. A low-risk lifestyle was defined as not smoking, having a body mass index (BMI) of less than 25, exercise duration of 30 minutes/day or longer, and consuming a diet closely related to a Mediterranean-style diet (emphasizes high intake of vegetables, fruits, nuts, legumes, whole grains and fish, with moderate alcohol intake).During the 26 years of follow-up, there were 321 cases of SCD among women (average age 72 years at the time of the SCD event) in the study. All four low-risk factors were significantly and independently associated with a lower risk of SCD. Not smoking, exercising and eating a healthy diet each were inversely associated with risk of SCD. BMI also was associated with the risk of SCD, with women having a BMI between 21 and 24.9 at lowest risk.Women at low risk for all four lifestyle factors had a 92 percent lower risk of SCD when compared with women at low risk for none of the four lifestyle factors."In this cohort of female nurses, adherence to an overall healthy lifestyle was associated with a lower risk of SCD and may be an effective strategy for the prevention of SCD," the authors write.
WASHINGTON, July 20 (Xinhua) -- Using the Hubble Space Telescope, astronomers have discovered a fourth moon orbiting the icy dwarf planet Pluto, the U.S. National Aeronautics and Space Administration (NASA) announced Wednesday in a statement. The tiny, new satellite, temporarily designated P4, was uncovered in a Hubble survey searching for rings around the dwarf planet.P4 was first seen in a photo taken with Hubble's Wide Field Camera 3 on June 28. It was confirmed in subsequent Hubble pictures taken on July 3 and July 18. It is the smallest moon discovered around Pluto. It has an estimated diameter of 8 to 21 miles (13 to 34 km). By comparison, Charon, Pluto's largest moon, is 648 miles (1,043 km) across, and the other moons, Nix and Hydra, are in the range of 20 to 70 miles in diameter (32 to 113 km).Two labeled images of the Pluto system taken by the Hubble Space Telescope's Wide Field Camera 3 ultraviolet visible instrument with newly discovered fourth moon P4 circled. The image on the left was taken on June 28, 2011. The image of the right was taken on July 3, 2011."I find it remarkable that Hubble's cameras enabled us to see such a tiny object so clearly from a distance of more than 3 billion miles (5 billion km)," said Mark Showalter of the SETI Institute in California, who led this observing program with Hubble.P4 is located between the orbits of Nix and Hydra, which Hubble discovered in 2005. Charon was discovered in 1978 at the U.S. Naval Observatory and first resolved using Hubble in 1990 as a separate body from Pluto.The dwarf planet's entire moon system is believed to have formed by a collision between Pluto and another planet-sized body early in the history of the solar system. The smashup flung material that coalesced into the family of satellites observed around Pluto.The finding is a result of ongoing work to support NASA's New Horizons mission, scheduled to fly through the Pluto system in 2015. The mission is designed to provide new insights about worlds at the edge of our solar system. Hubble's mapping of Pluto's surface and discovery of its satellites have been invaluable to planning for New Horizons' close encounter."This is a fantastic discovery," said New Horizons' principal investigator Alan Stern of the Southwest Research Institute in Colorado. "Now that we know there's another moon in the Pluto system, we can plan close-up observations of it during our flyby."
BEIJING, Sept. 11 (Xinhua) -- Despite a series of disasters, Chinese people tend to believe that the moon is still round and bright in the Mid-autumn Festival.Falling on Monday, the 15th day of the eighth month in the Chinese calendar, it is an important Chinese holiday, next only to the Spring Festival, and a chance for family reunion under the full moon, a symbol for happiness and prosperity.A staff worker shows newly-cooked moon cakes during a Mid-autumn festival celebration activity held in Tianjin, north China, Sept. 11, 2011. Some 100 children from Tianjin and southeast China's Taiwan attended the activity on Sunday.FAMILY REUNIONIn the railway station of Nanjing, capital city of east China's Jiangsu Province, passengers lined in long queues while waiting for their trains on Saturday.Although the three-day holiday seemed too short for a long trip, Xiao Liang carried several bags with him. "I bought wine for my dad, boiled salted duck for my mom, and health products for my grand parents," the young man beamed.In the southwestern Guangxi Zhuang Autonomous Region, Li Yukun didn't believe that she could reunite with her son for holiday. In fact, she never thought she could see the three-year-old boy again.Two years ago, Xiao Wei (pseudonym) from the Dalun village of the Beiliu city was kidnapped. His parents were desperate. "On special occasions like the Mid-autumn Festival, we shed tears while missing him," Li said.Police finally managed to get clues that a similar boy was adopted in the neighboring Guangdong Province.Li prepared for a feast with policemen to celebrate reunion with Xiao Wei.Since a campaign was launched to rescue trafficked children in Guangxi in 2009, 339 children were saved, half of whom had been sent back and could reunite with their parents in this festival.In Sichuan, 10 prisoners with good records in jail were given an opportunity to go back home for the holiday."In the past I could only receive greetings from my relatives behind the bars," a woman surnamed Chen said. "This year, my dream for home finally came true."Meanwhile, 171 prisoners had their jail terms shortened so that they could be released before the Mid-autumn Festival.
来源:资阳报