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The South Bend Police Department offers its sincerest condolences to Officer Alan Wiegand and his family during this difficult time following the tragic loss of their child while in Puerto Rico. The department asks the community to pray for the entire Wiegand family as they grieve and to respect their privacy.Royal Caribbean Cruises called it a tragic incident and said they were helping the family. They declined additional comment. 443

The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The RV industry has seen a significant increase in rentals and sales over the summer. One company, RVshare, reported more than a 1,000% increase in rentals.Now, the trend seems to be moving beyond just a summer vacation alternative. Some are turning to it as a new way to home-school and work during this pandemic.Some families are turning these RVs into their primary or secondary homes."I think it is difficult for families to be cooped up," said Julie Partridge.Partridge was already considering making the switch to RV life before the pandemic, but after five months of social distancing and quarantining in her home, she decided to finally do it.She sold the family home and hit the road to live, home-school her kids and work from an RV."Obviously our camper is much smaller than our house,” said Partridge. “Substantially smaller, but you have this vast open world available to you. You feel less cooped up in this camper than you do in this 3,000 square foot house."She also feels the move to full-time RV life this fall will also give her kids a unique educational opportunity."We really want to see the national parks,” said Partridge. “I want my kids to do the park ranger program. I want to use that as their science and social studies curriculum from the road. So, we are really excited about those parts."The Partridge family is just one of many either committing to or newly considering RV life in the fall, according to a survey done by the RV rental company RVshare."We have, from our survey, seen that over 30% of people are considering homeschooling from the road and over 40% of people are considering working from the road and that is something that is new to the industry," RVshare Jon Gray."You have school not opening on time, you have a lot of employers turning to work from anywhere models for the extended future and those things have made it to where RVs are appealing deep into the fall," said Gray.The pandemic has changed so much in our lives. Many people are looking to get away from the uncertainty and continued concern with it. This seems to be one way for some to do that."It is saving us money, it is teaching them lessons, it has really been kind of refreshing," said Partridge. 2224

The U.S. Postal Service has announced its holiday shipping deadlines as we approach a holiday season like none in our lifetime.Delivering cards and gifts through the mail may be more important than ever this year because many people will refrain from visiting loved ones to prevent the spread of the novel coronavirus.The Postal Service says you can you rely on them to deliver your parcels to family and friends, whether they’re overseas, across the country or just on the other side of town.USPS officials recommend the following mailing and shipping deadlines for expected delivery by Christmas Day to domestic addresses and Air/Army Post Office/Fleet Post Office/Diplomatic Post Office addresses:Nov. 6 — APO/FPO/DPO (all ZIP Codes) USPS Retail Ground serviceDec. 9 — APO/FPO/DPO (ZIP Code 093 only) Priority Mail and First-Class MailDec. 11 — APO/FPO/DPO (all other ZIP Codes) Priority Mail and First-Class Mail servicesDec. 15 — USPS Retail Ground serviceDec. 18 — APO/FPO/DPO (except ZIP Code 093) USPS Priority Mail Express serviceDec. 18 — First-Class Mail service (including greeting cards)Dec. 18 — First-class packages (up to 15.99 ounces)Dec. 19 — Priority Mail serviceDec. 23 — Priority Mail Express* serviceUSPS also suggests skipping the trip to your post office and using their online tools to ship your items.The Postal Service anticipates Dec. 14 will be its busiest day online with more than 13 million consumers predicted to visit usps.com for help shipping things. Officials estimate nearly 500,000 consumers will use their Click-N-Ship feature and other online services on that day to order Priority Mail boxes, print shipping labels, purchase postage and even request free next-day package pickup.The Postal Service has offered these tips for a successful holiday mailing and shipping season:Use free Priority Mail Flat Rate boxes. They are available at local Post Offices or online at usps.com/freeboxes.Make it easy with Click-N-Ship. You can create shipping labels and pay for postage online at usps.com/ship.Schedule a free Package Pickup when the carrier delivers your mail. It’s free regardless of the number of packages. Or, pickups can be scheduled at usps.com/pickup.Mail and packages that weigh more than 10 ounces and/or are more than a half-inch thick using stamps as postage cannot be dropped into a collection box or left for a carrier to pick up. Instead, take them to a window clerk at a Post Office. 2448

The US economy added 155,000 jobs in November, the Labor Department reported Friday. That's fewer than expected, but the unemployment rate remained steady at 3.7%.October's jobs numbers were also revised down slightly, to put the monthly average over the past year at about 204,000 jobs, and the average over the last quarter at 170,000.The report is a sign of a slowing but still strong labor market — and further support for the idea that the Federal Reserve may hold off hiking interest rates over the next year as quickly or as much as initially planned.That's reassuring to investors who had been worried that the Fed would move too fast to cool off an already decelerating economy."My reaction is a sigh of relief," said Leo Grohowski, chief Investment Officer at BNY Mellon Wealth Management. "I think a mild miss is more than acceptable in order to help the Fed understand that multiple rate increases may not be warranted for 2019."Paychecks grew by 3.1% over the last year, a relatively robust number that is in line with expectations as employers have had to fight to attract workers in recent months.The percentage of people participating in the labor force remained the same and the median number of weeks people remained unemployed dropped from 9.4 to 8.9 weeks in November, suggesting that people are getting jobs more quickly after losing them.However, the number of people "marginally attached" to the labor force — those who had looked for a job in the past year but stopped in the past month because they couldn't find one — has risen by nearly 200,000 over the past year. The percentage of people working part time who would rather work full time also rose slightly.Despite high demand for workers in some sectors, that may show that people who want jobs increasingly aren't in the places where employers need them — and that the economy still has room to expand before running out of workers entirely.The strongest job growth came in health care, transportation and warehousing, and manufacturing, which added another 27,000 jobs for 288,000 total growth over the past year. Tariffs and fears of a larger trade war may not be having a huge positive impact, but they're definitely not choking the sector either.The-CNN-Wire? & ? 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved. 2335

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