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WASHINGTON, Sept. 14 (Xinhua) -- Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published Wednesday in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells.Led by Yale Professor Hugh Taylor, the researchers bathed endometrial stem cells in cultures containing special nutrients and growth factors. Responding to these substances, the endometrial stem cells adopted the characteristics of beta cells in the pancreas that produce insulin. Over the course of a three- week incubation process, the endometrial stem cells took on the shape of beta cells and began to make proteins typically made by beta cells. Some of these cells also produced insulin.After a meal, the body breaks food down into components like the sugar glucose, which then circulates in the blood. In response, beta cells release insulin, which allows the body's cells to take in the circulating glucose. In this study, Taylor and his team exposed the mature stem cells to glucose and found that, like typical beta cells, the cultured cells responded by producing insulin. The team then injected diabetic mice with the mature, insulin-making stem cells. The mice had few working beta cells and very high levels of blood glucose.Mice that did not receive the stem cell therapy continued having high blood sugar levels, developed cataracts and were lethargic. In contrast, mice that received the cell therapy were active and did not develop cataracts, but the animals' blood sugar levels remained higher than normal.The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.Taylor said in a statement that the next step in the research will be to verify how long this treatment remains effective.

CANBERRA, Aug. 3 (Xinhua) -- As many as a quarter of Australian women have experienced some form of assault or sexual abuse, and the higher proportion of the abuse, the higher rates of metal illness a woman tends to suffer from, a new study released on Wednesday found.Researchers from the University of Melbourne and the University of New South Wales conducted the study survey of 4451 Australian women aged 16 to 85. It looked at their experience of the four most common types of gender-based violence - sexual assault, rape, stalking and being badly beaten by their partners.About 15 percent of Australian women report sexual assault, while eight percent report rape, 10 percent said they have a stalker and eight percent report being beaten by their partner.It found strong links between those four types of violence and mental health problems including attempted suicide, posttraumatic stress disorder, panic attacks, depression, anxiety, and substance abuse.Among the women who experienced at least one form of violence, 30 percent had a mood disorder, nearly 40 percent an anxiety disorder, 23 percent were abusing substances and 15 percent were affected by posttraumatic stress syndrome.For the women who suffered higher levels of violence, the rates of anxiety disorders was 77 percent, 52 percent for mood disorders, substance abuse 47 percent and posttraumatic stress syndrome 56 percent.More than six percent of women experienced one form of violent had attempted suicide, compared to 35 percent of women who suffered at least three forms of violence.Public health expert Dr Susan Rees from the University of New South Wales' school of psychiatry, who led the research, said she is especially concerned about the suicide rate of women who are abused."What we found was that there's a high association or a strong association between exposure to gender-based violence and all the three broad classes of mental disorder - so that includes mood, anxiety, substance abuse - and a very high association with attempted suicide," she said in the report released on Wednesday."Women who've not experienced gender-based violence have about a 1.6 percent rate of attempted suicide and that increased to six percent of women who had experienced one type of gender-based violence."She said that gender-based violence was also associated with physical disability, impaired quality of life and a worsening of any existing mental disorders.Dr Rees called for the health care system, particularly psychiatric services, to work closer with women's services to improve support for victims of violence.She added that the federal government also need to underscore the importance of getting to the root cause of the violence against women by looking at attitudes towards women and gender inequality.The study was published in the Journal of the American Medical Association.
CANBERRA, Sept. 7 (Xinhua) -- A team of Australian and U.S. scientists on Wednesday said they discovered a genetic defect, which can lead to Leigh syndrome, a rare disorder which affects the central nervous syndrome.The scientists tested more than 1000 genes by encoding proteins active in two individuals who suffer from the illness. They used a new technique known as next-generation DNA sequencing to examine the genes.The gene they discovered encodes an enzyme which is found in the mitochondria which are subsets of cells. Without this enzyme the mitochondria do not translate proteins efficiently, and this then causes Leigh syndrome.According to David Thorburn, from the Murdoch Children's Research Institute in Melbourne, the discovery shows the enormous potential of the new technology."These findings demonstrate the ability of sequencing technologies to improve diagnosis," Professor Thorburn said in a statement released on Wednesday."Although it isn't clear in the case of Leigh syndrome whether the precise molecular diagnosis will necessarily lead to therapies, the current findings represent a meaningful service."He added that diagnosis of the disease along with its specific genetic cause can also be informative about the risk a couple has of having another affected child. The diagnostic information can help in decisions about whether and how to pursue alternative means of having children, for instance through the use of donor sperm or eggs.The research team consisted of scientists from Australia's Murdoch Institute as well as the Broad Institute in the U.S.In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of three. The problem is that the mitochondria responsible for powering their cells cannot keep up with the demand for energy in their developing brains.
CANBERRA, June 6 (Xinhua) -- Australian beef is not to blame for a recent outbreak of E.coli in Japan, Meat and Livestock Australia confirmed on Monday.Twenty people have fallen ill in Japan's Toyama prefecture, with 15 of them infected with the O157 strain of E.coli after eating at a popular Korean-style barbecue restaurant chain, Gyukaka, on May 6.The operators of the restaurant chain, REINS International, said they suspected the bacterium might have been carried by beef imported from Australia.After conducting an investigation into the Japanese outbreak, regional manager for Meat and Livestock Australia, Melanie Brock, said testing shows Australian beef was not the source of the outbreak."The Toyama prefecture health authorities have confirmed following a thorough inspection that imported Australian beef was not the source of an incident of E.coli," Brock said in a statement on Monday."The authorities continue to investigate other food consumed by the affected customers."Brock said Australian beef has long been recognized by the Japanese trade and consumers for its strong safety record.Brock added that Australian beef for export to Japan is processed under the veterinary supervision of the Australian Quarantine and Inspection Service, and is recognized internationally as bearing a high hygienic standard.
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