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AstraZeneca is the latest drugmaker to announce promising Phase 3 trial results from its COVID-19 vaccine candidate.On Monday, AstraZeneca said its two-shot vaccine candidate has been 90% effective thus far along with no safety concerns.“These findings show that we have an effective vaccine that will save many lives," said Professor Andrew Pollard, the chief executive of the study. Excitingly, we’ve found that one of our dosing regimens may be around 90% effective and if this dosing regime is used, more people could be vaccinated with planned vaccine supply. Today’s announcement is only possible thanks to the many volunteers in our trial, and the hard working and talented team of researchers based around the world.”The company added in its press release that its vaccine candidate offers two distinct advantages over vaccines made by Pfizer and Moderna — it's cheaper to produce, and does not need to be stored in ultra-cold conditions before use.AstraZeneca added that the company would "immediately" prepare regulatory paperwork to seek Emergency Use Listing status from the World Health Organization.AstraZeneca is just the latest drug company to report encouraging results from its COVID-19 vaccine candidate.Last week, Pfizer said it had submitted Emergency Use Authorization paperwork to the Food & Drug Administration (FDA) after a final analysis of its vaccine candidate proved to be 95% effective in preventing COVID-19. The FDA is expected to approve the drug in the coming weeks.Moderna has also said that early results show its vaccine candidate to be 95% effective, and is on track to have the drug approved for Emergency Use Authorization by the end of the year.AstraZeneca, Pfizer and Moderna are all shattering records for vaccine development. The three vaccines are all on track to be approved for widespread use in uder a year. Typically, it takes several years for a vaccine to go from development to approval.The announcement comes as COVID-19 is spreading around the world at a rate not previously seen since the pandemic began. And while all three companies are pre-producing their vaccines in the hope that it will be approved, health experts warn that they won't be widely available until spring 2021. 2247

As states prepare to assist in distributing potential coronavirus vaccines by November 1, Surgeon General Jerome Adams doubted a vaccine would be ready so soon.Speaking to ABC’s Good Morning America, Adams said a Nov. 1 vaccine was “possible, but not probable.”Last week, the federal government asked states to be prepared to begin assisting in distribution of COVID-19 vaccines to the public this fall.The memo signed by CDC head Robert Redfield told governors that the federal government has contracted with the McKesson Corporation to assist in distributing the vaccine to local and state health departments, medical facilities, doctor officers, and other vaccine providers.So why is the government getting states ready for a vaccine on November 1 even if it’s unlikely a vaccine will be approved by then?"It's not contradictory information," Adams told Good Morning America. "We've always said that we're hopeful for a vaccine by the end of this year or the beginning of next year.""We want to make sure states are available to distribute it," he added.While there is urgency for both public health and economic reasons for a vaccine, some experts have expressed concern over the speed of a vaccine and whether the expedited timeline is long enough to demonstrate efficacy. Dr. Anthony Fauci told NBC News on Wednesday that he believes a “safe and effective” vaccine could be ready by the end of the year."I believe that by the time we get to the end of this calendar year, that we will feel comfortable that we do have a safe and effective vaccine," he told NBC News.On Monday, a third vaccine candidate entered “Phase 3” trials in the US. AstraZeneca is testing its COVID-19 vaccine candidate for 30,000 participants. The AstraZeneca vaccine would come in two separate doses, according to the National Institutes of Health.Even though a vaccine could be ready by year’s end, trials will be expected to continue for over a year to monitor for possible side effects.According to the FDA, a typical Phase 3 trial would take one to three years.“NIH is committed to supporting several Phase 3 vaccine trials to increase the odds that one or more will be effective in preventing COVID-19 and put us on the road to recovery from this devastating pandemic,” said NIH Director Francis S. Collins, M.D., Ph.D. “We also know that preventing this disease could require multiple vaccines and we’re investing in those that we believe have the greatest potential for success.”On Friday, President Donald Trump reiterated that a vaccine would be ready soon."We have tremendous, tremendous talent, some tremendous scientists, and they're right there, and I think you're going to hear some very good news,” Trump said. 2714

At least five Marines assigned to the prestigious ceremonial Silent Drill Platoon in Washington were placed in pretrial confinement in recent days due to allegations they were involved in hazing at least one Marine at the unit, according to three defense officials.Hearings that took place this week resulted in one Marine being released from confinement but all could still face charges as the Naval Criminal Investigative Service has taken over the matter.The number of alleged victims has not been made public but the allegations came to light when one Marine came forward. Officials say a video had been made allegedly showing some Marines hitting at least one other Marine. It is not publicly known if that victim is the Marine who came forward.The platoon is a 24-man rifle unit that performs a drill exhibition largely in silence. It was founded in 1948 and performed for presidents and top officials as well as communities around the country tossing and spinning 10-pound M1 rifles with fixed bayonets.Multiple performances of the drill team were canceled in recent weeks due to the ongoing investigation, according to officials. The Marines did not publicize the reason for those cancellations or which performances were affected. The Marines said they began an investigation immediately at the unit, before turning it over the NCIS.The unit and the Marines are well known in the Washington community where they reside. In September they gained attention when several Marines ran to a nearby apartment complex to help rescue elderly residents when it caught fire. 1580

AUSTIN, Texas -- Valarie Allman has been throwing discus for 10 years.“When you throw a discus it takes about two seconds, and it’s a combination of power, of grace, of strength… I like to think of it as a dance still," Allman said.She started sophomore year of high school. But it’s her dance background that she credits for her quick progression in the sport.“I had a weird knack for it," Allman said. "I think all those years of learning choreography and spinning and doing pirouettes weirdly carried over to the discus, and it kind of just seemed like a good fit right from the start.”Multiple days every week, she trains hard in the gym guided by her coach Zebulon Sion.“I’m responsible for every facet of her training," Sion said. "So that includes the strength-training concepts, if we do any type of running, fitness oriented things, plyometrics, and then of course the actual throwing.”Their chemistry is undeniable.At only 25 years old, Allman is considered a pro athlete. Her rigorous training is fueled by her desire to be a part of the next Olympics.“When I graduated college, I think that was the motivation to keep training. I missed the team in 2016 by three feet and it was kind of in that moment that I realized that I really wanted to try again,” Allman said.Consistency, discipline, attention to detail. Allman’s focus didn’t falter until she found out the 2020 Olympics had to be postponed.“It was pretty heartbreaking," Allman said. "I mean, to feel like you’ve put in so much to be prepared for it and to be healthy and to do everything right to feel like you’d have a chance to make the team and then for it to be postponed I think it kind of just made me question everything.”“Her motivation to throw kind of was gone a bit for her for a while," Sion said. "And then we kind of got to a point after a month, month-and-a-half of training going well in terms of lifting and training -- our goal was to get fit, get strong and refine the technical model that she has to get to a point where we could be at our best if that opportunity would come.”That opportunity did come. On August 1st in Rathdrum, Idaho, Allman beat the Women's Discus American Record.“I threw 70 meters and 15 centimeters, and the previous record was 69 meters and 17 centimeters.”The three-foot difference that kept her from qualifying for the Olympics in 2016 is the difference she surpassed to become the first and only American woman to throw past 70 meters.“When you’re throwing that type of distance, three feet is significant. So to break it by almost three feet was huge actually,” Sion said.“When they measured the throw and they read out the numbers and it started with a seven I instantly burst into tears. I was absolutely shocked,” Allman said.Allman says 70 meters is the ultimate barrier. In the past 20 years, only two other women in the world have thrown past 70 meters.“Now looking back it’s wild the think it was just a sliver of a difference of giving up when we were on the brink of something incredible,” Allman said.“We could have called it we could have said 2020 is a bust ya know let’s move on," Sion said. "But the amount of time, energy, effort all the things to put in over five months of uncertainty and then for that to happen – I don’t know if I could be more proud.”The same day of her record-breaking throw was the exact day she would have been competing in Tokyo had the Olympics continued. However, with her dedication to improvement, Sion believes there’s a great future ahead of Allman.“I mean I think the goal is just to throw farther and to keep throwing far more often. I mean it’s pretty simple,” Allman said.Even more simple when you’re having fun. 3692

ATLANTA (AP) — Rapper and actor T.I. has settled civil charges with the U.S. Securities and Exchange Commission that he helped promote a fraudulent cryptocurrency. T.I., whose real name is Clifford Harris, agreed to a civil settlement with the SEC that was announced Friday. He's paying a ,000 fine and agreeing not to sell or market similar securities for at least five years. A representative for T.I. did not immediately respond to an email seeking comment on Monday. The charges against Harris were part of a larger enforcement action against others including film producer Ryan Felton, who faces wire fraud and other charges in a 28-count indictment unsealed Wednesday. 685

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