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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

Capt. John Watkins, whose daughter passed away at 10 months of age from cancer, joins thousands of participants for Oceanside's The IRONMAN triathlon race to raise awareness for childhood cancer.Watkins posted a Facebook message to his daughter, Millie Mae, on Friday saying his heart was heavy as he prepared for the big race."Today marks 10 months. You had 10 full months of life with us on this Earth and we now have spent the same amount of time without you," the post read.-------------------Ironman 70.3Where: Oceanside Harbor; Cost: FreeYou can go out and root for the talented athletes competing in Oceanside's Ironman competition. The public is also welcomed to check out the Ironman Village. 724

CAPE CANAVERAL, Fla. (AP) — SpaceX's sleek, new crew capsule arrived at the International Space Station on Sunday, acing its second milestone in just over a day.No one was aboard the Dragon capsule launched Saturday on its first test flight, only an instrumented dummy. But that quickly changed once the hatch swung open and the space station astronauts floated inside."A new generation of space flight starts now with the arrival of @SpaceX's Crew Dragon to the @Space_Station," NASA Administrator Jim Bridenstine tweeted. "Congratulations to all for this historic achievement getting us closer to flying American Astronauts on American rockets."This beefed-up, redesigned Dragon is the first American-made, designed-for-crew spacecraft to pull up to the station in eight years. The next one coming up will have its own two-man crew.The space station's three astronauts had front-row seats as the white 27-foot-long (8-meter-long) capsule neatly docked, a little early no less. TV cameras on Dragon as well as the station provided stunning views of one another throughout the rendezvous.Just two hours after the Dragon's grand entrance, the station crew entered to take air samples. The astronauts wore oxygen masks and hoods until getting the all-clear.If the six-day demo goes well, SpaceX could launch two astronauts this summer under NASA's commercial crew program. Both astronauts — Doug Hurley and Bob Behnken — were at SpaceX Mission Control in Southern California, observing all the action. They rushed there from Florida after watching the Dragon rocket into orbit early Saturday from NASA's Kennedy Space Center."Just super excited to see it," Behnken said minutes after the link-up. "Just one more milestone that gets us ready for our flight coming up here."While SpaceX has sent plenty of cargo Dragons to the space station, crew Dragon is a different beast. It docked autonomously under the station astronauts' watchful eyes, instead of relying on the station's robot arm for berthing. The capsule's nose cap was wide open like a dragon's mouth, to expose the docking mechanism.Behnken said that's the way it should work when he and Hurley are on board; they may push a button or two and will have the ability to intervene, if necessary.As part of Sunday's shakedown, the station astronauts sent commands for the Dragon to retreat and then move forward again, before the capsule closed in for good.SpaceX employees at company headquarters in Hawthorne, California, cheered and applauded as crew Dragon pulled up and docked at the orbiting lab, nearly 260 miles (400 kilometers) above the Pacific, north of New Zealand. They burst into applause again, several minutes later, when the Dragon's latches were tightly secured.The capsule's lone passenger for launch — a mannequin wearing a white SpaceX spacesuit — remained strapped into its seat as the station's U.S., Canadian and Russian crew removed supplies and photographed the spotless white interior. The test dummy — or Smarty as SpaceX likes to call it, given all the instrumentation — is named Ripley after the lead character in the science-fiction "Alien" films.Dragon will remain at the space station until Friday, when it undocks and aims for a splashdown in the Atlantic, a couple hundred miles off the Florida coast.Like Ripley, the capsule is rigged with sensors to measure noise, vibration and stresses, and to monitor the life-support, propulsion and other critical systems throughout the flight.SpaceX aims to launch Behnken and Hurley as early as July.Next up, though, should be Boeing, NASA's other commercial crew provider. Boeing is looking to launch its Starliner capsule without a crew as early as April and with a crew possibly in August.NASA is paying the two private companies billion to build and operate the capsules for ferrying astronauts to and from the space station. Astronauts have been stuck riding Russian rockets ever since NASA's space shuttle program ended in 2011. Russian Soyuz seats go for up to million apiece. 4030

BUFFALO, N.Y. (WKBW) — It’s a conversation no one wants to have, but for many it’s necessary.“You don’t know what’s going to happen if one of us is left alone,” said Amy Paoletti of Williamsville.Getting life insurance in a COVID-19 world has Paoletti and her husband looking at their options.“You see so many people of all ages dying and no one has anything covered because it just happened,” she said.Paoletti says with owning her own business, Amy’s Fine Jewelry in Williamsville, New York, and her husband working in healthcare, they’re both in contact with many people daily.They’re looking at their life insurance options in case something were to happen to either.“They look at your age, your health and your lifestyle,” said Demetrius Mack, owner of MackBarr Group. Mack helps people with financial literacy and sells life insurance.“We’re in a situation where it’s important that we’re proactive instead of reactive,” he said.Mack says the COVID-19 pandemic has made it harder for people to get life insurance, partly because the underwriting process is taking longer.He says If you’ve had COVID-19 or have a risk for COVID-19, insurers don’t consider you as healthy as someone else, and that could mean if you are approved for a policy, you’ll be paying more.“If you’re more suspect to COVID-19, you’re going to have to fit a certain criteria in order to get said policy,” he said.A lot of people are looking to get life insurance to protect their loved ones if something were to happen.“Making sure you save that money and that you have life insurance,” he said. “The only guarantee we have in life is death, and unfortunately when that time does come you leave people you care about in a really tough situation,” he said of those who do not have the insurance.Mack says if there ever were a time to look into financial planning and your financial future, to make sure you and your family can make ends meet, the time is now.This article was written by Hannah Buehler for WKBW. 1996

CARLSBAD, Calif. (KGTV) — Authorities have identified the woman found stabbed to death on a North County trail.San Diego County Medical Examiner identified the woman as 68-year-old Lisa Thorborg of Carlsbad. Thorborg was found fatally stabbed on the Hosp Grove trail on Monday, Carlsbad Police say.Police believe the stabbing occurred between about 10 a.m. to 11 a.m., before her body was found by a passerby who called police around 11:30 a.m.RELATED: Carlsbad police: Woman found dead on hiking trail was stabbed to deathA tipster led investigators to identify a suspect as white or Hispanic, 5 feet 10 inches to 6 feet 3 inches tall, with a husky build and a tan complexion with dark hair. The tipster told police the man was wearing a black shirt, black shorts, and possibly a black hat, and he was walking slowly with a slight shuffle or limp.Anyone with information on the case or who was in the area of Hosp Grove Trail East, between 10 a.m.-12 p.m., is asked to call Carlsbad Police at 760-931-2165."We have put all available resources toward solving this case and ensuring our community’s safety," said CPD Lt. Jason Jackowski. "At this time, we need to hold back some details known only to law enforcement, but rest assured we will release more information just as soon as we can." 1299