山东痛风的痛苦(济南尿酸会导致痛风吗) (今日更新中)

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — County public health officials have released guidance for celebrating Halloween this month, including recommendations for trick-or-treating and parties.The county is recommending that residents avoid traditional door-to-door trick-or-treating, "trunk-or-treating" where candy is offered from cars, or leaving bowls of candy for others at their door this Halloween due to the pandemic.For those who want to find a safe alternative to traditional trick-or-treating, the county recommends "one-way" trick-or-treating where residents leave individually wrapped goodies bags outside for families to grab while maintaining physical distance, such as at the end of the driveway or yard.Parents are also asked to consider giving away treats other than candy, such as stickers, pencils, or mini pumpkins that can be sanitized by parents before given to kids.There are several activities that are not allowed, according to the county, including:In-person gatherings, parties, and events with non-household members even if gatherings are outdoors because physical distancing will not be easy to maintain,Carnivals, petting zoos, festivals, and live entertainment are not allowed because of frequent interaction with high touch surfaces by children and participants, andAny gatherings already not allowed under current public health ordersHaunted houses are not recommended because of the potential for crowds in tight spaces and poor ventilation, making safety and social distancing a challenge.County officials recommend that San Diegans celebrate through:Online parties or costume contestsDrive-thru events and car paradesDecorating homes and yardsMovie nights within households or at drive-in theaters, andPumpkin patches where social distancing and increased hand hygiene is possibleThe county says that whichever way residents end up celebrating Halloween, it's important that they continue to wash and sanitize their hands often and thoroughly, avoid close contact with individuals that are not in the same household, wear a face covering, and stay home and away from others if sick.More Halloween safety resources are available on the county's website. 2175

SAN DIEGO (KGTV) — Custom churros are the latest foodie find on Kearny Mesa's bustling Convoy Street culinary scene.Churreria is taking the classic dessert treat and adding their own twist. The churro stop gives customers the chance to customize their churro with toppings like bacon, coconut, and even fruity pebbles. Better yet, churros are made right before customers' eyes.Nicholas Tran, owner of Churreria, said the idea for a churro shop developed after a trip by the border.RELATED: 10 must-eat restaurants on San Diego's Convoy Street"We saw this kiosk and they were having these churros from this little stand. And I was 'Oh my god. That's a fantastic idea,'" Tran said. "Everyone loves churros!"Tran's wife and his business partner embarked to Spain to develop how they would make their churros. The main difference, Tran, said is the basic ingredients.Traditional North American churros contain egg, milk, and butter. Spanish churros, though, are made from just flour, water, salt, and oil."It's vegan and vegetarian. It's good for people who are lactose intolerant or who have a dairy intolerance or with eggs," Tran. "This happens to be a healthy churro. What you put as your toppings I can't guarantee."RELATED: Top 7 dessert spots in San DiegoEnter the customizable feature of Churreria. Customers order whether they want their churro stuffed with Nutella or sweet cream or not, and then they can choose from different glazes and toppings, including sprinkles, nuts, and cookie crumbs."There's nothing to hide. We want to show you we make it from scratch and it's clean," Tran said.Another fun aspect of Churreria is its sustainability arm.Tran worked with his business partner to do something good with their cooking oil after use. The pair settled on donating the used oil to two areas: A local company that repurposes cooking oil into biofuel and a shelter that uses the oil for soap for homeless individuals."We try to put back into the community instead of just dumping the grease ... and having it hauled away," Tran said. "We're trying to be better for the environment that way." 2164

SAN DIEGO (KGTV) - Another child has been diagnosed with E. Coli linked to animals at the San Diego County Fair, San Diego Health and Human Services officials reported Tuesday. The latest case involves a 6-year-old boy who visited animals at the fair on June 22, officials said. The boy began showing symptoms of Shiga-toxin-producing E. Coli (STEC) four days later. He was not hospitalized. 2-year-old Jedediah Cabezuela died of the illness and three other children were sickened by E. Coli, fair organizers said Friday.RELATED: Family mourns toddler dead after E. Coli exposure at San Diego County FairHealth officials confirmed Tuesday a previously reported case involving a 9-year-old child who was not hospitalized was due to E. Coli. “As we continue our investigation, more cases are likely to be reported,” said Wilma J. Wooten, M.D., M.P.H, County public health officer. “This is typical of any public health investigation. Since we asked doctors to be on the lookout for STEC, they are more likely to test patients exhibiting symptoms.” E. Coli can incubate over a period of 10 days. Fair officials closed the animal exhibits to the public on June 28. RELATED: Two-year-old boy dead, three sickened due to E. Coli linked to San Diego County FairSymptoms of E. Coli include bloody or watery diarrhea, vomiting, and severe abdominal cramps. The infection is contracted through a naturally-occurring bacteria in animals. 1435

SAN DIEGO (KGTV) - Californians associate “The Big One” with a devastating earthquake, but U.S. Geological Survey experts say a potentially larger threat could hit the state in the form of an “ARkStorm.”SPECIAL REPORT: Complete coverage of California's winter stormsExperts from every scientific field related to a potentially disastrous weather event gathered in 2010 to create the ARkStorm Scenario report for the USGS, imagining aspects of flooding of biblical proportions reaching the Western United States.“These storms do pose a real risk to California, in some ways far greater than that of earthquakes,” experts said in the study.The ARkStorm Scenario report reads like a Hollywood post-apocalyptic film script. Weeks of rain and snow are followed by catastrophic floods, landslides, and property and infrastructure damage which would cripple California’s economy.While the name “ARk” brings to mind a lifeboat scenario, ARkStorm project manager Dale Cox and chief scientist Lucile Jones coined the abbreviation to represent “atmospheric river.” A common term for meteorologists, these rivers in the sky work like highways for water vapor which comes to a screeching halt when it reaches land.A typical atmospheric river is the Pineapple Express, which pushes moisture from the tropics to the West Coast. It was a Pineapple Express that reached San Diego on Valentine’s Day, bringing warmer rain and lower snow levels, according to National Weather Service meteorologist Alexander Tardy.RELATED: Mega storm could cause billions in damage to California, report showsModels in the ARkStorm report show multiple areas of submergence in central San Diego. Mission Beach, which routinely sees flooding during heavy rain, is underwater in the ARkStorm scenario. Fiesta Island, ordinarily dry, disappears under Mission Bay.West-facing beaches, including those near Highway 1 in North San Diego County, are covered in water. Imperial Beach fares no better in its known run-off spots.“You have this outflow then you have the storm pushing in; it dams up,” says Cox of the coastal flooding impact.RELATED: How to check if your neighborhood is at risk of floodingTiming is critical in the creation of an ARkStorm. The same amount of precipitation predicted in the ARkStorm Scenario fell in 2017, says Cox. What made the difference in the impact, he says, is that the rain fell in 80 days instead of the 23 days imagined in the report.The West Coast will get notice, but not much, Tardy says. The most reliable models could give Californians a three-week warning for heavy rain.“We’re going to see it coming, but not where we can build a new levee,” Tardy said.RELATED: How San Diego's flooding compares to FEMA's historical hazard mapThe timing of the next ARkStorm is uncertain.“It could be next year, or it could be 120 years from now,” said Tardy.San Diego has seen significant rainfall in the 2018-2019 season, but few storms in recent years can compare with the potential disaster envisioned in ARkStorm.RELATED: Photos: Flooding catches San Diego by surprise“How do we help people understand it can get bigger than what they remember,” Jones said. “We prepare for the ones that we remember.”To create the report, experts accessed information from the records of Spanish ships off the coast of San Francisco in the 1600s. Other data were collected from tree rings, and newspaper reports from Sacramento in 1861 and 1862, the years an epic storm submerged California’s Central Valley past the level of telephone poles.As severe as it may seem, the ARkStorm Scenario is not the worst case scenario, said Jones.“If it has happened, it can happen again. And it probably will happen again.” 3695

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