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With five weeks remaining in the college football season, the College Football Playoff selection committee unveiled the first poll, and there is little surprise at who is at the top. Alabama, the defending national champs, was ranked No. 1 in the poll released Tuesday, followed by the 2017 champs No. 2-ranked Clemson. With Alabama and Clemson both sporting unbeaten records, it is not surprising to see the two squads at the top of the ranking. But the selection committee's third choice might leave some fans scratching their head. Rather than picking unbeaten Notre Dame at No. 3, the selection committee slotted one-loss LSU as the third pick. Notre Dame, who has a win over Michigan who is ranked at No. 5 in the CFP ranking, was at No. 4. With the toughest part of Notre Dame's schedule in the past, and no remaining Top 25 games remaining on the schedule, the Irish's chances of making the College Football Playoff are in question given that a one-loss team is already ahead of Notre Dame. A group of other one-loss teams are poised to potentially overtake Notre Dame at the No. 4 spot since most of those squads will get the opportunity to play in a conference title game. With Notre Dame being an independent, the Irish do not get the benefit of playing in a conference championship. Behind Michigan is a quintet of teams sporting 7-1 records going into Week 9. Those teams are No. 6 Georgia, No. 7 Oklahoma, No. 8 Washington State, No. 9 Kentucky and No. 10 Ohio State. UCF, who is the only other unbeaten team besides Alabama, Clemson and Notre Dame, was ranked No. 12. The top four teams at the end of the season advance to play in the College Football Playoff.  1728

When Linda Beigel Schulman heard that a geography teacher was among the victims of the Parkland shooting, she knew it was her son. And she knew she had to be with him.Schulman, her husband and her brother rushed to look for flights out of the New York area. They couldn't find an open seat with a commercial airline, so they called Talon Air, a charter jet company, to fly to Scott's side.The company's clients include Martha Stewart and Lebron James, according to their website."I had no idea what the charge was at the time. It really didn't matter what the charge was," she told CNN. "I was convinced in my mind that my son was in the hospital and I needed to get to him as fast as possible."What Schulman did not expect, however, was that she would be charged an additional ,000 for the empty plane's return to New York the next day, bumping the bill up to a total of ,459.13 dollars.Once she landed, Schulman learned her son, Scott J. Beigel, had died that February day after unlocking his classroom door to allow students to seek shelter. He was one of the 17 people who lost their lives after Nikolas Cruz opened fire in the halls of Marjory Stoneman Douglas High School.The family promptly paid the whole amount with funds from Scott's life insurance policy. But they asked Talon Air to reconsider the return flight charge since they did not travel back on the plane. The company refunded ,000 dollars and told them it was all they could do. 1475

With a .6 billion Mega Millions jackpot up for grabs Tuesday night, lottery players across the country are no doubt looking for any edge they can get.Disclaimer: Your odds of winning the Mega Millions jackpot are 1 in 302,575,350, no matter which numbers you pick or where you buy your tickets.Mathematicians say the simplest way to increase your odds is to buy more tickets. Think about it: Two tickets give you twice the chance (though your odds are still minimal), and buying 100 million tickets would give you a 100 million chances (but you could still lose, and lose 0 million in the process).Whatever you do, don't overspend. Mega Millions reminds players that gambling can be addictive and very damaging. The information below is presented solely for entertainment purposes only, and the E.W. Scripps Co. is not responsible for any losses incurred by using the following tips.  947

With a coronavirus vaccine still months off, companies are rushing to test what may be the next best thing: drugs that deliver antibodies to fight the virus right away, without having to train the immune system to make them.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. Vaccines work by tricking the body into thinking there’s an infection so it makes antibodies and remembers how to do that if the real bug turns up.But it can take a month or two after vaccination or infection for the most effective antibodies to form. The experimental drugs shortcut that process by giving concentrated versions of specific ones that worked best against the coronavirus in lab and animal tests.“A vaccine takes time to work, to force the development of antibodies. But when you give an antibody, you get immediate protection,” said University of North Carolina virologist Dr. Myron Cohen. “If we can generate them in large concentrations, in big vats in an antibody factory ... we can kind of bypass the immune system.”These drugs are believed to last for a month or more and could give quick, temporary immunity to people at high risk of infection, such as health workers and housemates of someone with COVID-19. If they proved effective and if a vaccine doesn’t materialize or protect as hoped, the drugs might eventually be considered for wider use, perhaps for teachers or other groups.They’re also being tested as treatments, to help the immune system and prevent severe symptoms or death.“The hope there is to target people who are in the first week of their illness and that we can treat them with the antibody and prevent them from getting sick,” said Dr. Marshall Lyon, an infectious disease specialist helping to test one such drug at Emory University in Atlanta.Having such a tool “would be a really momentous thing in our fight against COVID,” Cohen said.Vaccines are seen as a key to controlling the virus, which has been confirmed to have infected more than 20 million people worldwide and killed more than 738,000. Several companies are racing to develop vaccines, but the results of the large final tests needed to evaluate them are months away.The antibody drugs are “very promising” and, in contrast, could be available “fairly soon,” said Dr. Janet Woodcock, a U.S. Food and Drug Administration official who is leading government efforts to speed COVID-19 therapies. Key studies are underway and some answers should come by early fall.One company, Eli Lilly, has already started manufacturing its antibody drug, betting that studies now underway will give positive results.“Our goal is to get something out as soon as possible” and to have hundreds of thousands of doses ready by fall, said Lilly’s chief scientific officer, Dr. Daniel Skovronsky.Another company that developed an antibody drug cocktail against Ebola — Regeneron Pharmaceuticals Inc. — now is testing one for coronavirus.“The success with our Ebola program gives us some confidence that we can potentially do this again,” said Christos Kyratsous, a Regeneron microbiologist who helped lead that work.Regeneron’s drug uses two antibodies to enhance chances the drug will work even if the virus evolves to evade action by one.Lilly is testing two different, single-antibody drugs — one with the Canadian company AbCellera and another with a Chinese company, Junshi Biosciences. In July, Junshi said no safety concerns emerged in 40 healthy people who tried it and that larger studies were getting underway.Others working on antibody drugs include Amgen and Adaptive Biotechnologies. The Singapore biotech company Tychan Pte Ltd. also is testing an antibody drug and has similar products in development for Zika virus and yellow fever.“I’m cautiously optimistic” about the drugs, said the nation’s top infectious diseases expert, Dr. Anthony Fauci. “I’m heartened by the experience that we had with Ebola,” where the drugs proved effective.What could go wrong?— The antibodies may not reach all of the places in the body where they need to act, such as deep in the lungs. All the antibody drugs are given through an IV and must make their way through the bloodstream to wherever they’re needed.— The virus might mutate to avoid the antibody — the reason Regeneron is testing a two-antibody combo that binds to the virus in different places to help prevent its escape.Skovronsky said Lilly stuck with one antibody because manufacturing capacity would essentially be cut in half to make two, and “you will have less doses available.” If a single antibody works, “we can treat twice as many people,” he said.— The antibodies might not last long enough. If they fade within a month, it’s still OK for treatment since COVID-19 illness usually resolves in that time. But for prevention, it may not be practical to give infusions more often than every month or two.A San Francisco company, Vir Biotechnology Inc., says it has engineered antibodies to last longer than they usually do to avoid this problem. GlaxoSmithKline has invested 0 million in Vir to test them.Giving a higher dose also may help. If half of antibodies disappear after a month, “if you give twice as much, you will have two months’ protection,” Lilly’s Skovronsky said.— The big fear: Antibodies may do the opposite of what’s hoped and actually enhance the virus’s ability to get into cells or stimulate the immune system in a way that makes people sicker. It’s a theoretical concern that hasn’t been seen in testing so far, but large, definitive experiments are needed to prove safety.“As best as we can tell, the antibodies are helpful,” Lyon said.___Marilynn Marchione can be followed on Twitter: @MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 5919

When it comes to educating America's children, how much of a difference could million make? Could it send a second grader on a school trip to the museum, or provide updated equipment to a class of budding scientists?It can. In fact, it can do it 35,647 times.Ripple, a cryptocurrency and international payment company, has donated million in cryptocurrency to DonorsChoose.org, a donation platform that connects people to classroom needs across the country. With the money, Donors Choose was able to fulfill every single classroom project request on its site -- 35,647 requests in all, from 28,210 teachers at 16,561 public schools."It's fair to say there's never been a day that this many classroom dreams have come true," Donors Choose founder Charles Best told CNN.The Colbert bumpThe massive donation is the culmination, or grand finale, if you will, of the site's #BestSchoolDay project. Two years ago, Stephen Colbert, who is a member of the Donors Choose board of directors, announced he was going to pay for every school project request in his home state of South Carolina.His act of kindness set off a movement that became known as #BestSchoolDay."More than 50 actors, athletes and philanthropists were inspired to fund classrooms in their states," Best told CNN. "Together, those 50-plus people gave more than million, and to use, that represented the idea of a best school day."Best says the response has been overwhelming -- in a good way."An outpouring of joy would not be an overstatement," he said.The Ripple effectBest says when the organization connected with Ripple, the cryptocurrency management company was "inspired to think of the impact" of such a significant gift."At Ripple, we care about giving back to our community and we collectively value the importance of quality education in developing the next generation of leaders," Ripple's SVP of Marketing Monica Long said in a statement."DonorsChoose.org's track record speaks for itself — they are highly effective at improving the quality of education and the experience of teachers and students across America. We're proud to work with them to support classroom needs across the country."According to Ripple's company site, the donation will affect approximately 1 million public school students.Best says the "classroom projects" requested on the site represent specific missions or activities that teachers have for their students."It's a public schoolteacher requesting a classroom library. A field trip. A set of art supplies. A pair of microscopes. It's about requesting experiences or tools to provide a student learning experience," he said."We believe in the wisdom of the front lines," Best added. "Hardworking, passionate teachers know their students' needs better than anyone else in the school environment. If we can tap into their needs, we can unleash smarter solutions and empower those people on the front lines."  2956