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WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

SAN FRANCISCO, Aug. 9 (Xinhua) -- Nokia is planning to stop selling its low-end phones and smartphones in the United States, instead focusing on products using Microsoft's Windows Phone platform, U.S. media reported on Tuesday.The Finnish handset maker will end sales of its low-end Series 40 phones and smartphones based on the Symbian mobile operating system in the United States and Canada, as it needs to put all of its efforts into the Windows Phone products which are due out later this year, Chris Weber, head of Nokia's U.S. subsidiary, told technology news site All Things Digital."When we launch Windows Phones we will essentially be out of the Symbian business, the S40 business, etc.," Weber said.Staff members speak to trade visitors at the Nokia booth at the CommunicAsia expo in Singapore June 21, 2011.In February, Nokia and Microsoft announced plans to form a broad strategic partnership, under which Nokia agrees to adopt Windows Phone as its principal smartphone strategy.North America is a priority for Nokia, Weber noted, in part because it is a key market for Microsoft and also because Nokia sees it as a key to winning in the smartphone battle globally."We'll develop for North America and make the phones globally available and applicable," Weber said.In another development, technology blog Engadget and other U.S. media on Tuesday reported that Nokia will not bring N9, its first smartphone running the Linux-based mobile operating system MeeGo, to the U.S. market."After the very positive reception to the launch of the Nokia N9, the product is now being rolled out in countries around the world. At this time we will not be making it available in the U.S., " Nokia said in a statement.

UNITED NATIONS, June 8 (Xinhua) -- Marking 30 years of the HIV- AIDS pandemic, scores of heads of state and government and ministers took to the UN General Assembly podium on Wednesday to list their country's accomplishments and list challenges in the battle.The General Assembly High Level Meeting on AIDS is taking place 10 years after the UN Special Session on HIV/AIDS and also marks five years since signing of the Political Declaration in which UN member states committed to moving towards universal access to HIV prevention, treatment, care and support.UN Secretary-General Ban Ki-moon UN recalled how three decades ago AIDS was spreading while "Today, we have a chance to end this epidemic once and for all."Now, instead of fear, there is hope, he said."Today, HIV is on a steep decline in some of the most affected countries. Countries like Ethiopia, South Africa, Zambia and Zimbabwe," he said. "They had the largest epidemics in the world, and they have cut infection rates by one quarter.""Globally, more than 6 million people now get treatment," Ban said. "All of these advances come thanks to you and the commitments you made, first 10 years ago and then again in 2006. Today, the challenge has changed. Today, we gather to end AIDS."However, President Joseph Deiss of the General Assembly said 10 million people still have no access to treatment and far too many people were still being infected, adding it was necessary to continue complementary and closely-linked prevention, treatment, care and support measures."We have reached a critical moment in time," he said. "We must take a holistic approach and integrate the response to AIDS into broader development programs."Michel Sidibe, executive director of the Joint UN Program on HIV/AIDS (UNAIDS), recalled how 30 years the disease was called the gay plague and slime disease. People were afraid of each other and there was no hope."This image should not disappear. It is part of our history," he said.Sidibe said the AIDS movement was the story of a people breaking the conspiracy of silence, demanding equity and dignity, confronting societies'wrongs, seizing their rights, and making a passionate call for social justice. Since then, a compact had been made between the global North and the South, which had produced lifesaving results.Now, More than 6.6 million people are being treated in low- and middle- income countries, he said, pointing out that since the initial success stories in Uganda and Thailand 56 countries, including 36 in Africa, have been able to stabilize the epidemic and reduce the number of infections significantly.Infections have been reduced by 35 percent in South Africa and by more than half in India, the UNAIDS chief said. In China, the HIV mortality rate had fallen by 64 percent, Sidibe said. Many other countries had reached universal access to treatment.He voiced what was repeated several times, and that was a call for "a transformational agenda" of "zero infections, zero discrimination and zero AIDS-related deaths."To put a personal face on the disease, a woman from Ukraine openly living with HIV, Tetyana Afansiadi, told her story to the delegates.She told how she had been living with HIV and using drugs for 13 years, had hepatitis C for almost 11 years but now has a husband and an 8-year-old son. Neither have HIV.Three years ago she took part in a drug therapy program that has enabled her to live, work, and take care of her son."Drug dependency and HIV-infection require treatment, not prosecution," she said.Given that opioid substitution therapy in her home city had changed the lives of people like her, it was time to stop refusing antiretroviral treatment to people who used drugs.While the heads of states and government and ministers, usually those heading up health departments, spoke in the General Assembly hall under bright lights, scores more of delegates attended five panel sessions and about 40 individual side events.Some samplings from the spotlighted dark-green podium in the great hall:President Paul Kagame of Rwanda, said, "It is time to galvanize member states to commit to a transformative agenda that overcomes the barriers to an effective, equitable and sustainable response to HIV and AIDS."Jose Angel Cordova Villalobos, health minister of Mexico, called for states to implement friendly, non-discriminatory healthcare systems as well as sex education in order to prevent the spread of HIV/AIDS."To achieve this, we call to all the countries congregated here today in order that your actions are based in the framework of respect to the human rights and focusing on gender equity, that allow to consolidate an effective response to the HIV/AIDS without stigmas, discrimination, homophobia, transphobia; as well as any type of violence," he said, referring, in part, to transsexuals.The vice president of Mauritius, Monique Bellepeau, said, "The adverse impact of the AIDS epidemic on the socioeconomic progress, particularly in the developing countries, dictates that there is no time for complacency."She added, "After wrestling with AIDS for the past three decades, we are today equipped with a vast body of knowledge and various new tools to urgently complete the task. No less than strict prevention efforts and universal access to treatment, care and support are required."The speeches continue Thursday and on the final day of the three-day meeting, UN member states are expected to adopt a declaration to guide country responses to HIV over the next five years.

BEIJING, Sept. 6 (Xinhuanet) -- San Francisco police said they had helped Apple search for a "lost item," following reports saying that a prototype of Apple's yet-to-be-released iPhone 5 had gone missing in July.Last week, technology news website CNET reported that an Apple employee lost at a tequila bar in San Francisco in July a prototype of iPhone 5, a new version of the company's mobile phone expected to be released in September or October.The San Francisco Police Department said in a press release that after the missing device was tracked using GPS technology to a San Francisco house, four police officers and two Apple employees visited the home."Apple employees called Mission police station directly, wanting assistance in tracking down a lost item," the statement said."The two Apple employees met with the resident and then went into the house to look for the lost item," it said. "The Apple employees did not find the lost item and left the house."Police did not say exactly what Apple had lost, but media reports found the file of San Francisco police's Friday press release about the hunt was named "iphone5.doc" -- an apparent hint of the new mobile device.A 22-year-old resident of the home, identified by SF Weekly as Sergio Calderon, told the newspaper that he has visited the bar where the phone was reportedly lost but he did not have the device.Calderon said the search of his house took place in July when police had traced the phone to the house using satellite positioning software on the device, but did not find anything in the house.Apple has declined to comment on the matter.Last year, an employee of the company lost a prototype iPhone 4 in a Redwood City bar before it was released. The details of the phone ware then unveiled by technology blog Gizmodo.Criminal charges have been filed against the man who found the prototype and another who brokered the deal to sell it to Gizmodo. Both men pleaded not guilty on Thursday.

CANBERRA, Sept. 9 (Xinhua) -- Australia on Friday launched the first national study to find out whether low to moderate levels of alcohol drank by pregnant women are harmful or not to an unborn child, hoping to provide a clear indication about the safe amount of alcohol for pregnant women.The Murdoch Children's Research Institute in Melbourne, which commissioned the study, is recruiting 2000 pregnant women who will be quizzed throughout their pregnancy about their drinking habits, general health and diets.Their babies will then undergo medical checks, when they turn one and again at two to see if their brains, development and behavior was affected by alcohol consumed by their mums.According to lead researcher associate professor, Jane Halliday, while there was solid evidence about the dangers of heavy drinking for an unborn baby, it was not known if there was a safe amount of alcohol pregnant women could drink.She said the study hoped to shed light on the best approach to alcohol use during pregnancy."The problem is that for about half of women that get pregnant it is unplanned, and a lot of women are drinking around the time they get pregnant and may drink for the first month or so and that creates a lot of anxiety," Assoc Prof Halliday said in a statement."From the few international and Australian studies there's conflicting evidence as to whether there's an adverse effect."We firmly believe that no drinking is the safest option, but our main aim is to provide an evidence base to the policy and answer questions about individual risks."The study came after research by the University of Newcastle published in 2010 revealed 80 percent of Australian women drank during pregnancy.