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WASHINGTON, July 5 (Xinhua) -- Intake of high levels of folate, a water-soluble B vitamin that occurs naturally in food, may reduce colorectal cancer risk, according to a new study published Tuesday in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. "We found that all forms and sources of folate were associated with lower risk of colorectal cancer," said lead author Victoria Stevens, of the American Cancer Society. "The strongest association was with total folate, which suggests that total folate intake is the best measure to define exposure to this nutrient because it encompasses all forms and sources."Total folate includes naturally occurring food folate and folic acid from fortified foods and dietary supplements.The research team investigated the association between folate intake and colorectal cancer among 99,523 participants in the Cancer Prevention Study II Nutrition Cohort; a total of 1,023 participants were diagnosed with colorectal cancer between 1999 and 2007, a period entirely after folate fortification began. Neither higher nor lower risk was observed during the first two years of follow-up (1999 to 2001), while associations were statistically significantly inverse for the subsequent years (2002 to 2007). The findings of this study add to the epidemiologic evidence that high folate intake reduces colorectal cancer incidence.Folates are essential nutrients needed to make components used for functions required for normal cell growth, including DNA synthesis and repair. Because these processes are critical for cell growth and differentiation, the relationship between folate intake and cancer development has been investigated in several cancers, and most extensively in colorectal cancer.

HONG KONG, July 19 (Xinhua) -- A gene controlled by male hormone was critical for the growth of liver tumor, leading to a higher incidence of the disease in men than in women, according to the Chinese University of Hong Kong which made the results public on Tuesday.There is a significant gender bias in liver cancer incidence. In Hong Kong, men are three times more likely to develop liver cancer than women. Such phenomenon prompted researchers from the university to carry out a genomic location analysis in liver cancer cells starting from 2008.The researchers discovered, out of 17,000 human genes, that a gene called Cell Cycle-Related Kinase (CCRK) was directly controlled by androgen receptor. They further found that CCRK was critical for the induction of signaling pathway leading to abnormal liver cell growth and tumor formation.The results also reveal that 70 percent of patients with liver cancer were found to produce high levels of CCRK. More importantly, these patients were more likely to have late-stage cancers and lived shorter than those with low CCRK level.Using mouse models, the researchers found that either lowering the level or blocking the signaling pathway of CCRK in liver cancer cells could significantly reduce the tumor growth rate.The study has validated that CCRK is an important gene that has potential to cause liver cancer and the gene can be tested as a new targeted therapy in future.Vice-Chancellor of the university Joseph Sung, who is also team leader of the research project, said the results explained why men have a higher risk of liver cancer than women and helped push ahead with the development of a novel treatment of the disease.The above study results were published online in July in Journal of Clinical Investigation.

WASHINGTON, Aug. 2 (Xinhua) -- A new study has identified the recent emergence of a multidrug-resistant strain of Salmonella that has a high level resistance to ciprofloxacin, a common treatment for severe Salmonella infections. The study was published on-line Tuesday in The Journal of Infectious Diseases.Francois-Xavier Weill at the Pasteur Institute in France and colleagues studied information from national surveillance systems in France, England and Wales, Denmark, and the United States. The data showed that a multidrug-resistant strain of Salmonella, known as S. Kentucky, infected 489 patients in France, England and Wales, and Denmark between 2000 and 2008. In addition, researchers reported that the first infections were acquired mainly in Egypt between 2002 and 2005, while since 2006 the infections have also been acquired in various parts of Africa and the Middle East. The absence of reported international travel in approximately 10 percent of the patients suggests that infections may have also occurred in Europe through consumption of contaminated imported foods or through secondary contaminations.In this study, multidrug-resistant S. Kentucky was isolated from chickens and turkeys from Ethiopia, Morocco, and Nigeria, suggesting that poultry is an important agent for infection. The common use of fluoroquinolones in chicken and turkey production in Nigeria and Morocco may have contributed to this rapid spread, according to the researchers.This study highlights the importance of public health surveillance in a global food system. The investigators reported that they will continue to monitor this multidrug-resistant strain as well as help strengthen the capacities of national and regional laboratories in the surveillance of Salmonella and other major foodborne pathogens through the World Health Organization Global Foodborne Infections Network.Salmonella infection represents a major public health problem worldwide. An estimated 1.7 million such infections occur in North America each year. More than 1.6 million cases were reported between 1999 and 2008 in 27 European countries. Although most Salmonella infections produce only mild gastroenteritis, elderly and immunocompromised patients are especially at risk for life- threatening infections. These cases are typically treated with antimicrobials called fluoroquinolones, such as ciprofloxacin.

BEIJING, Aug. 3 (Xinhuanet) -- NASA Tuesday confirmed a 4-foot in diameter sphere debris as a fuel tank that was part of the space shuttle Columbia's electrical power system,according to U.S. news reports.NASA engineers identified the 4-foot piece of spherical debris as one of the18 tanks that held chilled oxygen and hydrogen used by the shuttle's electricity-generating fuel cells.This Aug. 1, 2011 handout photo provided by the Nacogdoches Police Department shows a 4-feet in diameter sphere found in Lake Nacogdoches, Texas on Monday, Aug. 1. Police say low water levels at the lake during the drought have led to recovery of a container-like object that could be from space shuttle Columbia. The shuttle broke apart and burned in February 2003, scattering remnants over East TexasPolice in the city of Nacogdoches, about 160 miles northeast of Houston, said Monday the low water levels of Lake Nacogdoches during the record drought revealed an unexpected object that could be from space shuttle Columbia. The shuttle broke apart and burned as it re-entered the atmosphere on February 1, 2003.The tank will be moved to the Kennedy Space Center, where the rest of the Columbia is stored. Approximately 40 percent of the spacecraft has been recovered.

MOSCOW, Aug. 6 (Xinhua) -- The Arctic is getting warmer at a fast pace with the Russian Arctic sector's ice areas contracting to historically low levels, according to Russian meteorological bureau Rosgidromet.According to a Rosgidromet report cited by Itar-Tass news agency Saturday, the polar cap in the Russian sector has shrunk to the historical low registered in 2007, with no ice expected to block the Northern Seaway at least until September."Currently, Arctic navigation conditions are very favorable. By early August, navigation can be done without icebreakers almost along the entire route," said Valery Martyshchenko, head of Rosgidromet's environment pollution monitoring department.According to the Arctic and Antarctic Research Institute, the current ice cover in the Arctic Ocean is 6,860 million square kilometers, way below average.Martyshchenko said the longer period of icebreaker-free navigation would benefit the regions located in the Arctic area, allowing longer access to food and energy supplies, but the warming of the climate also posed new threats, such as melting of ice and forming of icebergs.