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The US Food and Drug Administration pressed forward with its investigation of e-cigarette companies Friday, sending letters to 21 companies in an effort to uncover whether they are marketing products illegally and outside the agency's compliance policy.This latest phase of the investigation addresses more than 40 e-cigarette products and is part of the agency's ongoing efforts to combat e-cigarette use among youth. It also comes less than two weeks after the agency conducted a surprise inspection of e-cigarette maker Juul's corporate headquarters in San Francisco, seizing thousand of documents, many of which relate to its sales and marketing practices."Companies are on notice," FDA Commissioner Dr. Scott Gottlieb said in a statement Friday. "The FDA will not allow the proliferation of e-cigarettes or other tobacco products potentially being marketed illegally and outside of the agency's compliance policy, and we will take swift action when companies are skirting the law."In September, Gottlieb called the increasing teen use of e-cigarettes "an epidemic," adding that teen nicotine use is dangerous to young people's health and brains.Federal law prohibits the sale of e-cigarettes to people under the age of 18, but more than 2 million middle and high school students were current users of e-cigarettes in 2017, according to the FDA. The US Centers for Disease Control and Prevention says it's the most common nicotine product used by middle and high schoolers.Also last month, the FDA requested that five major e-cigarette manufacturers, including Juul, explain how they plan to combat the use of their products by minors. The agency said it was looking into steps to eliminate the sale of flavored products and unveiled a public education campaignabout e-cigarettes.The FDA said it's considering civil and criminal avenues to enforce these regulations, including fines, seizures and injunctions, according to Friday's announcement.CNN reached out to some of the companies that received letters for comment but did not immediately receive a response."We're going to address issues related to the access kids have to e-cigarettes, as well as the youth appeal of these products," Gottlieb said Friday. "We know flavors are one of the principal drivers of the youth appeal of e-cigarettes and we're looking carefully at this."No reasonable person wants to see these products reaching epidemic use among kids," he said. 2500

The surviving members of a grief-stricken Oregon family who believe a 13-year-old boy died while trying to save his grandmother in a wildfire detailed their harrowing attempts to escape the fire. The Statesman Journal reported that 13-year-old Wyatt Tofte of Lyons, Oregon, and his 71-year-old grandmother Peggy Mosso are among the six reported fatalities in the state from the ongoing fires. Wyatt, who was found Wednesday with his dog, is survived by his parents Angela Mosso and Chris Tofte. Angela Mosso is being treated at a burn center in Portland. More than 40,000 Oregonians have been evacuated from their homes so far and about 500,000 are in different levels of evacuation zones.The West Coast wildfires so far have consumed more land area than the size of Connecticut. In California, 10 people have died so far, with more missing. 850

The world's biggest COVID-19 vaccine test got underway Monday with the first of 30,000 planned volunteers. The experimental vaccine is made by the National Institutes of Health and Moderna Inc. It's one of several candidates in the final stretch of the global vaccine race. Officials are seeking to find out whether more people who get dummy shots become infected than those given two doses of the real vaccine. The U.S. government plans separate huge studies of several leading vaccine candidates through fall, each in hot spots where the virus still is spreading.Dr. Anthony Fauci and other Trump administration officials have said that the company is already producing millions of doses of the vaccine in the event that it receives Emergency Use Authorization from the FDA following the trial. Fauci remains cautiously optimistic that a vaccine could be available by January of next year — though it's unclear how long it would take for a vaccine to be available for all Americans who want it. 1004

The Senate on Wednesday will hold a hearing regarding the safety of vaccines, which will feature appearances by Surgeon General Dr. Jerome Adams and National Institutes of Health Director Dr. Francis Collins.The hearing, hosted by the Senate HELP Committee, will discuss the role of vaccines in preventing infectious disease outbreaks and protecting public health.Wednesday's hearing will also include information on a potential COVID-19 vaccine.Top U.S. health experts like Dr. Anthony Fauci say they are cautiously optimistic that there will be enough evidence to grant Emergency Use Authorization to top vaccine candidates by the end of 2020. However, recent polls indicate that some Americans remain skeptical about vaccines.A recent CBS News poll indicates that just 21% of American voters would receive a COVID-19 if one were made available at no cost. That's down from about 30% earlier this year. Two-thirds of those polled say they feel a vaccine would be "rushed" if a vaccine were made available this year.Fauci has said that if a potential vaccine is 75% effective against the virus, it still may not be effective in promoting inoculation levels necessary for "herd immunity" in the U.S. due to Americans' ongoing skepticism about vaccines.Nine vaccine makers banded together to sign a pledge on Tuesday to say that they will not seek Emergency Use Authorization for their vaccine candidates until scientific methods prove they are safe for widespread use. 1476

The top 10 has been reduced to seven.After airing live coast-to-coast on Sunday, three American Idol hopefuls were eliminated from the competition.(Spoiler alert: If you continue reading, you will learn who was eliminated from the competition.)After "millions" of votes were cast throughout the two-hour show, host Ryan Seacrest revealed that Ada Vox, Dennis Lorenzo and Melissa Sussette had not received enough votes to move on to the competition's next round.The judges looked shocked. Naturally, people took to Twitter to share their reactions.Here is a look at the Top 7: 593