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SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) — The family of a beloved South Bay fruit vendor are outraged after an unidentified white female who they say has been hurling racial slurs towards the Latino man allegedly threatened acts of violence against him and his wife on Wednesday.The woman has reportedly been harassing the vendor over the last several weeks. The woman escalated her verbal abuse to physical threats and allegedly brought someone along with her described as being "intimidating," the family says.A Facebook live stream from a local business owner capturing himself reporting the incident to two San Diego County Sheriff's deputies says the vendor was confronted six or seven times throughout the day. In the video, the vendor is heard telling deputies that the woman threatened to "beat" him and his wife."Come and support him; we can't let this continue," Victor Lopez says in his broadcast.The 51-year-old vendor, known by many South Bay locals as the “Mango Man,” and his wife have been selling cases of fresh produce in Bonita out of his truck. His family says it’s a job he's been doing for over a decade to help supplement his income."He's always been really good with the people, and people always supported him," says Cony Plata, the vendor's daughter-in-law.Cony describes her in-laws, Gilberto and Yolanda, as hardworking and kind people "just trying to make ends meet."Like many San Diegans scrambling to manage the pandemic, Gilberto is out of work. He stresses over paying bills and keeping his family under a roof.Gilberto, who is often seen sporting a baseball cap emblazoned with an American flag and bald eagle, first came under attack by a small group of people several weeks ago. In the last few days, the group ratcheted up their racist insults with threats of violence, according to Cony.Cony says her father-in-law stays positive for the family, but the xenophobia and verbal ambushing are adding unnecessary pressure."Lately, it's been harder for them because they get all these threats and harassment," says Cony. "They said they're going to beat them up … this lady said she's going to bring people.”Gilberto, a soft-spoken man with an unassuming disposition, tells his family he's never experienced hatred of this kind."It's making them more nervous and scared because they don't know if these people are actually going to do something to them," she says.Fears for his family's safety are made worse by the nagging feeling that people may be following Gilberto to his home. Cony says that his vehicle was broken into recently, and that a rope used to tie down his fruit crates was stolen out of his truck.The rope has “never gone missing before until these incidences started happening," she says.Videos, photos, and stories of these confrontations against the Mango Man have been quietly surfacing on social media over the last month. La Toya Ventura was one of the first people to witness the confrontations. On Aug. 5, Ventura posted a 3-minute video recorded by her daughter to a community Facebook page purporting to show an older white female harassing the vendor."She’s still there after calling the police & threatening to call BP on him. If you’re in the area please stop by & buy a box. It’s ," she wrote in the video's caption.Word of the harassment spread quickly and loudly this week, garnering interest from numerous locals and business leaders pledging support for Gilberto.Lopez is one of those supporters. He visited the fruit stand a week ago and witnessed the verbal threats on Gilberto and his wife. Lopez snapped photos and shared them on social media which moved the community into action."That same member who took photos happens to be a local restaurant owner, and bought 50 boxes of mangos! Mango Man sold out again!," wrote one Facebook user.The outpouring of support has led to a fan page, and locals are posting photos with the Mango Man and his wife. Images show customers donning face coverings and posing with cases of fruit, uniformed servicemembers holding up their purchases, and families standing guard at his stand.Photos are filling South Bay social pages daily and his produce is selling out everyday thanks in large part to the community's support."This kind of action demonstrates the human quality of the inhabitants of this community," reads one photo gallery caption on Facebook. "It is encouraging to know that there are more people who decide to support those who need it and generate common good by helping each other."Cony and her husband are in Las Vegas managing their own struggle, she says. For her and her husband, it’s hard to see what’s happening to their family hundreds of miles away. Until she can get time off from work, she appreciates the support she sees posted on social media."Thank you for being there and letting it be known they're not alone." 4848

SAN DIEGO (KGTV) — The crowds at San Diego International Airport grew Friday night, as travelers kicked off the holiday travel weekend. AAA predicts a record-breaking 115 million Americans will travel this holiday season, up nearly 4 percent from last year. Of those travelers, AAA estimates 105 million people will drive, 7 million will fly, and 4 million will take the train, bus, or cruise ships. According to AAA, airports around the US will be busiest between Dec. 21 through 23. But the crowds should start to build Friday.RELATED: This holiday season to set travel records, AAA says10News spoke to many travelers going in and out of San Diego International Airport Friday. Melissa Flatley flew in from Reno, Nev. She said she wore her festive antler headband to make sure her sister does not lose her in the crowd."It's a little busy on a holiday weekend, so I just wanted for her to find me a little more easily!" Flatley laughed. 10News also met the Monje family. The San Diego family of five was headed to Jacksonville, Fla., to visit family. They said they were travel pros, who purposely wait until the last second to fly, thanks to father Joel's job at Southwest Airlines. RELATED: AAA provides tips on preparing vehicles for holiday travel"We fly standby, so it's always a little frazzled and anxious for us," Lisa Monje said. "But we're very thankful for our benefits. If we can get there on standby for free, hey, that's even better!"Carlos Yu flew in from El Paso, Texas. He told 10News he's glad to be back home in Southern California and planning to take every form of transportation to make his rounds to see friends and family."I've actually never taken the train, so I'm super excited about that," Yu said. "I'm going to drive back down, actually again, so it's going to be a good two weeks."RELATED: The holidays bring a spike in heart attacks. Here's why10News also met the Smith family, who was waiting for their two sons to come home. Their father, Joshua, is in the Navy, based in San Diego. Older brother, Malik, is in the Army. He flew in from El Paso. Middle brother, Jauan, is in the Air Force. He arrived from San Antonio. They all came together from bases all over the country to spend the holidays together at home. "I literally cannot come home to see them until I have to leave to come and do it, so it means a lot. We all get together. It doesn't happen all the time," Jauan said. Santa and Mrs. Claus made an appearance to make sure travelers had a festive and stress-free experience at the airport. 2546

SAN DIEGO (KGTV) -- The Infinite Chemical Analysis Lab building in Miramar looks like any other chemical lab, but inside the products they are testing are all cannabis. InfiniteCal tests products for things like potency, pesticides, heavy metals and microbial analysis to make sure the products are safe for consumption and meet state standards. Josh Swider is the CEO and co-founder. Swider's company consists of roughly 45 employees, 30 of those are either chemists or biologists. The team tests products for licensed retailers to make sure their cannabis meets the standard for what is allowed by the state. When it comes to vaping, Swider says their analysis shows that what's making people sick is when the product is diluted, most recently with Vitamin E or Vitamin E acetate. According to the CDC, 33 people have died from lung related illnesses linked to e-ciggarettes or vaping products. Most of those samples tested by the FDA had THC. San Diego County has confirmed 22 vape related illnesses in the county. Although InfiniteCal doesn't just test products for vaping, Swider says the best thing a person can do is to do their research and make sure they are buying from a licensed retailer. He also recommends asking the business for their certificate of analysis to find out what's in the cannabis product they're consuming. InfiniteCal operates six days a week and also will tests an individual consumer's product if they show up to the lab. The company is expanding to a location four times it's current size by the end of the year. 1554

SAN DIEGO (KGTV) -- The all-clear was given after a suspicious device forced the evacuation of a building at San Diego City College Monday. The device was reported Monday afternoon in or near Building A, according to the school. The building serves as administrative offices. The college says no classes were affected by the evacuation. The building, as well as a cafeteria will remain closed for the remainder of the day. 431