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GENEVA — The U.N. health agency says the world’s largest randomized trial of COVID-19 treatments found “conclusive evidence” that remdesivir, a drug used to treat U.S. President Donald Trump when he fell ill, has little or no effect on severe cases. The World Health Organization has announced long-awaited results of its six-month “Solidarity Therapeutics Trial” that endeavored to see if existing drugs might have an effect on the coronavirus. The study, which was not peer-reviewed, found that four treatments tested — remdesivir, hydroxychloroquine, lopinavir/ritonavir and interferon — had “ little or no effect on 28-day mortality or the in-hospital course of COVID-19 among hospitalized patients.” Remdesivir was the only drug of the four that had not largely been ruled out as ineffective in fighting COVID-19. 826

GARDEN GROVE, Calif. (AP) — The man who killed four people and wounded two others in random stabbings across two Southern California cities is a gang member with a violent criminal record who had served time in prison, authorities said Thursday.Zachary Castaneda "could have injured or killed many other people" had he not been arrested Wednesday while carrying out attacks and robberies during the two-hour wave of violence that began in Garden Grove, the city's police Chief Tom DaRe said.It wasn't immediately known if Castaneda, 33, had a lawyer who could speak on his behalf. He was scheduled to be arraigned Friday.Castaneda was taken into custody when he walked out of a convenience store in the neighboring city of Santa Ana, dropping a knife and a gun he had taken from a security guard he had just killed, police said. The suspect was covered in blood, DaRe said.Castaneda was kept in restraints as detectives tried to interview him, the chief said at a press conference."He remained violent with us through the night," DaRe said. "He never told us why he did this."Castaneda has a conviction for possession of meth for sale while armed with an assault rifle, DaRe said. Investigators were still putting together his entire criminal history, he said. Officials didn't specify what crimes sent Castaneda to prison or when he was released.The violence appeared to be random and the only known motive seem to be "robbery, hate, homicide," Garden Grove police Lt. Carl Whitney told reporters.Whitney said police had previously gone to Castaneda's Garden Grove apartment to deal with a child custody issue. The suspect's mother had been living with him and had once asked police how she could evict her son, he said.The attacker and four of the victims were described as Hispanic, while two victims were described as white, police said in a statement. Initially, all had been described as Hispanic. There was no indication this was a hate crime, DaRe said.The two people who were wounded were expected to survive.One of the dead was identified by his son as a hard-working immigrant originally from Romania.Erwin Hauprich said in a telephone interview that his father, Helmuth Hauprich, 62, called him Wednesday afternoon and told him his Garden Grove apartment had been burglarized. The father said his passport, green card, sword collection and even a dining table were taken.Erwin Hauprich said his father never called back and he went to check on him after hearing there had been a stabbing at the complex.A police officer told him that Helmuth Hauprich had been taken to the hospital, where he died, the son said. He said he was told his father's roommate was killed in the apartment.A body was removed from the complex by stretcher Thursday.Erwin Hauprich said his father left Romania first for Germany and then the United States more than two decades ago. He said his father worked on an assembly line and lived in the complex for years.He said Helmuth Hauprich was a down-to-earth man who strove to make a life for his family.Police said surveillance cameras caught some of the carnage."We have video showing him attacking these people and conducting these murders," Whitney said.Whitney said the man lived in a Garden Grove apartment building where he stabbed two men during some kind of confrontation. One man died inside and the other at a hospital.Whitney said a bakery also was robbed.The bakery owner, Dona Beltran, said she was sitting in her car charging her cellphone when she saw a tattooed man get out of a Mercedes and go inside the business. Beltran, 45, followed him inside to offer help, but kept quiet when she saw him trying to open the cash register.She then ran out of the shop and yelled she was being robbed before taking refuge in a nearby dental office, she said. He ended up taking the entire register with him, which had about 0, she said."I saved myself because I was in the car," she said in Spanish on Thursday. "Thank God I am alive."The man also robbed an insurance business, where a 54-year-old employee was stabbed several times and was expected to survive.The woman "was very brave," Whitney said. "She fought as best she could."An alarm company saw the robbery on a live television feed and called police.The man fled with cash and also robbed a check-cashing business next door, the lieutenant said.Afterward, the attacker drove up to a Chevron station, where he attacked a man pumping gas "for no reason," Whitney said.The man was stabbed in the back and "his nose was nearly severed off his face," the lieutenant said.Undercover detectives tracked the suspect's silver Mercedes to the parking lot of the 7-Eleven in Santa Ana and within a minute the man emerged from the store, carrying a large knife and a gun that he had cut from the belt of a security guard after stabbing him, Whitney said.Police ordered the man to drop his weapons and he complied and was arrested.Police then learned that a male employee of a nearby Subway restaurant also had been fatally stabbed during a robbery, Whitney said.The brutal and puzzling attack came just days after a pair of mass shootings in Texas and Ohio left 31 people dead and stunned the nation.___Associated Press reporters Robert Jablon, John Antczak and Christopher Weber contributed from Los Angeles 5309

Have you ever looked at a person in an ad and wondered, what do they look like in real life? Now, with at least one company's ads, you won't have to wonder.CVS has unveiled a beauty campaign using un-retouched images, aimed at creating a more realistic standard of beauty. But do they really look that different?It's called the Beauty in Real Life campaign. CVS says the goal of this campaign is to create a new and more realistic standard of beauty. The way you can tell if an ad is a part of the campaign is it has a CVS Beauty Mark, a white stamp watermark that reads beauty unaltered.If you see the stamp on an ad it means that the images in the ad haven't been "materially altered." That means the brand did not "digitally alter or change a person's shape, size, proportion, skin or eye color or enhance or alter lines, wrinkles or other individual characteristics."So essentially if you saw the person in the ad walking down the street, they would look like they do in the ad. That's the goal, because in general, the editing of photos in ads really has has an impact on how women and girls feel about themselves.A survey found two out of three women strongly agree that the media has set an unrealistic standard of beauty. 80% of women feel worse about themselves after seeing a beauty ad. 90% of girls ages 15 to 17 want to change at least one aspect of their physical appearance.We asked a few people what they think about this new initiative."I think that's awesome," one woman said.  "I think we've been given unrealistic beauty standards for a really long time. So it's really nice to see companies putting in women who actually look like me. I don't have to have these unrealistic standards of what I should look like. I think it's a really awesome thing."Other women felt differently."Non touching is a good start," one woman said. "But if I saw that I would be like, real life? I don't know if I'd look like that in real life."Her friend agreed."When I wake up I do not look like that in real life," the woman said. "So I think like the touch up is a good start, but for that like slogan for the campaign I feel it's sending the wrong message in a way."This campaign is rolling out now digitally and the goal is for all the images in the beauty sections of CVS stores to reflect transparency by the end of 2020. 2339

GEORGETOWN, Del. (AP) — An 8-foot tall whipping post was removed from a Delaware county courthouse square Wednesday after activists said the post was a reminder of racial discrimination.The post outside the Sussex County Courthouse in Georgetown was removed after an hour and a half of excavation and put in storage unit with other historical artifacts.The Delaware Division of Historical and Cultural Affairs said the post was used to bind and whip people publicly for committing crimes up until 1952. However, Black people were disproportionately punished, according to the historical group.The group said the post was a “cold deadpan display” that didn’t “adequately account for the traumatic legacy it represents." 726

HAMPTON ROADS, Va. - When COVID-19 hit, most people wouldn’t have imagined working from home for this long. But for thousands of Americans working from home has become the new reality.Dr. Ryan Light from Tidewater Physicians Multispecialty Group said he has seen a significant increase in patients coming in for pain to their lower backs, eyes, joints, and hands. He said many don’t realize what is causing the pain. He attributes the pain to months of working from home and not having the proper work environment setup.“People are working in their bedrooms, people are working in their kitchens, they have probably tried multiple locations and still haven't found a comfortable location,” said Dr. Light.He said many times the pain increases over time. They don’t realize the pain is caused by the way they are sitting, working on their computer or laptop. He said the pain will creep in.Leaders with the American Chiropractic Association say they are seeing an increase in people with pain in their neck, shoulders, wrists, and hands, lower back pain, and experiencing headaches.Dr. Karen Erickson with the American Chiropractic Association, A.C.A said the hunched-over posture that people assume when they don't have a good ergonomic setup is causing a lot of the problems.ACA said they conducted a Facebook poll on April 21 and found that 92% of respondents noticed an increase in musculoskeletal issues such as back pain and neck pain among their patients and people they know since the stay at home guidance went into effect in March. There were about 200 people surveyed.Dr. Erickson said she too has seen an influx in patients coming to her. She said it is both new patients and those who she previously treated that need help again.“I have never been busier,” she said.She offered some suggestions for how people can make changes to their work environments to prevent pain. She said people should keep their computer screen or laptop at eye level.Dr. Erickson said looking down at your laptop and rounding your shoulders forward puts a lot of stress on your neck and your shoulders.She said sitting on a couch can also cause problems if the couch is deep or too soft. She said it can strain the lower back and she suggested using a hard chair.“Keep your feet flat on the floor with a 90-degree bend in your knee, a lot of people cross their feet under their chair and that actually puts a lot of stress on your low back,” said Dr. Erickson.And she suggests switching up your work environment by moving around your home if possible. She said spend a few hours in your office, move to the kitchen, put the laptop on the mantel, and stand. She said walk around while you are on phone calls and take breaks to go outside.She said many people are walking around in pain.“There's no big moment where they all of the sudden have an explosion of pain. It is just a little bit at a time and a lot of times we get used to just being in pain.”This story was first reported by Margaret Kavanagh at WTKR in Norfolk, Virginia. 3029