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BEIJING, Oct. 11 (Xinhuanet) -- An experimental drug that can remove amyloid plaques from the brains of Alzheimer's patients is being developed by Swiss Roche Holding AG in a small early-stage study, according to a report published in the Archives of Neurology on Monday.Researchers suspect the build-up of such plaques may be a cause of the memory robbing disease, although that theory has yet to be definitively proved. Gantenerumab, a biotech drug designed to bind to amyloid plaques in the brain and remove them, is being targeted at the early stages of Alzheimer's with the hope it can slow progression of the disease while patients are still able to function.The Phase I study of 16 Alzheimer's patients tested gantenerumab at two doses against a placebo over six months of treatment.The Roche drug led to a dose-dependent reduction of brain amyloid, while amyloid load increased in patients receiving a placebo, the report said.The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at doses of the experimental drug that are well tolerated and safe, the report said.Much larger trials and further study will be needed to fully understand how gantenerumab works and whether it can stave off Alzheimer's, said the report.Roche is approaching the disease far earlier because amyloid accumulates for 15 years before dementi.

OTTAWA, Nov. 21 (Xinhua) -- The leader of World Health Organization (WHO) Margaret Chan said in Canada on Monday that countries must make the health of women and children their highest priority.Speaking at a luncheon in Gatineau, Quebec, Chan said that maternal and infant health is the most pressing public health issue in the world.She made the remarks just hours after WHO announced Chan was the only candidate for the position on WHO director-general when Chan's appointment expires next year.An executive board meeting in Geneva between Jan. 16 and 23 will decide whether to put the name forward to the WHO Assembly in May, which would make the final decision regarding the appointment.Chan, a former health chief in China's Hong Kong, was elected director-general of the WHO in Nov. 2006.Before her tenure with WHO, Chan was head of public health in Hong Kong, where she managed the city's response to the world's first outbreak of the deadly H5N1 bird flu virus and an outbreak of Severe Acute Respiratory Syndrome (SARS).Speaking in Gatineau, Chan, who earned her medical degree in Canada, said that she never expected to rise to such a lofty position."I just wanted to be a doctor. I just wanted to take care of women and children. When I was studying in Canada, I thought I would get married and have children. I never guessed I'd do anything like head the World Health Organization," she said.She said that she will continue to focus the WHO's attention on mothers and young children.Chan said that it's difficult to know how many mothers and young children die of preventable diseases, since more than 80 countries don't keep accurate death records, but she said that millions of children under five years of age are dying.Millions more are growing up physically and mentally stunted because of poor nutrition and medical care, she added."Without proper nutrition, the stunting we are seeing is horrific," she said. Unless babies have good food, including being breast-fed as infants, they grow up physically and mentally under-developed, Chan said."The first few years of a child's life are make or break," she said.Chan and the WHO held a meeting of the Expert Panel on Maternal and Child Health in Canada from Nov. 18 to Nov. 21. The panel was established by the United Nations Commission on Information and Accountability for Women's and Children's Health Report. At the invitation of the WHO, the Commission was co-chaired by Canada's Prime Minister Stephen Harper and the President of Tanzania, Dr. Jakaya Kikwete.Chan says she's hopeful funding from developed nations will continue to expand, despite the debt crisis facing many of them. The situation resembles the 1970s, with spikes in energy and food prices along with cuts to national budgets to restrain debt.Chan said she is relieved the International Monetary Fund will not press for public health cuts in countries that are struggling with debt.Beverley J. Oda, Minister of International Cooperation who is responsible for Canada's official aid affairs, delivered remarks at the luncheon on improving the health of children and mothers locally and globally."I am particularly proud of the strong partnership between the WHO and Canada in advancing global health, and working towards improvements that will help us achieve our shared goals," she said.Last Friday, Oda announced 25 new initiatives to further Canada 's support to 23 projects in Africa concerning Children and Youth, Food Security and Sustainable Economic Growth.Seven of these are multi-country projects supporting efforts to prevent the mother-to-child transmission of HIV/AIDS, further improving child health, or increasing the capacity of African Regional Technical Centres. The others are targeted to support work in a range of individual African countries by working with Canadian, international and African-based organizations.

WASHINGTON, Oct. 3 (Xinhua) -- Researchers at St. Michael's Hospital in Canada have discovered a new function for an enzyme that may protect against organ injury and death from anemia, according to a study appearing Monday in the U.S. journal of the Proceeding of the National Academy of Sciences.Researchers found that when people have anemia, neuronal nitric oxide synthase (nNOS) -- an enzyme in nerve cells that produces nitric oxide, an important signaling molecule in the body -- increases the body's ability to respond, adapt to low oxygen levels and makes the body more efficient in delivering oxygen to tissues. They also found that levels of nNOS in the brain increased in anemic mice, and that the mice without this enzyme die earlier, and with higher hemoglobin levels."Identifying this mechanism may lead to new therapies and approaches to improving outcomes for anemic patients," said Dr. Greg Hare, a researcher at the Li Ka Shing Knowledge Institute of the hospital and one of the lead investigators of the study.Anemia occurs when blood has a lower than normal number of red blood cells or hemoglobin -- an iron-rich protein that carries oxygen from the lungs and heart to the rest of the body. Cells need oxygen to survive and to produce energy for all bodily functions. The condition has many different causes including infection (malaria, HIV, parasites), nutritional deficiencies (iron, folate, B12), genetic mutations, pregnancy, trauma and surgical blood loss."This research will help us identify when an anemic patient is at greatest risk for injury and death when undergoing surgery," said Hare. "Research is underway to test these findings in humans."

BEIJING, Oct. 20 (Xinhuanet) -- British scientists used bacteria and DNA to build basic components for digital devices in a new research, according to media reports, suggesting biological computers come closer to reality.Digital devices are based on logic gates, fundamental building blocks in silicon circuitry, said Professor Richard Kitney, leading researcher of the research published in the journal Nature Communications, "Without them, we could not process digital information."According to Science Daily, Professor Kitney and his colleagues from the Imperial College London replicated the building blocks using bacteria and DNA, forming biological logic gates, which paved the way for building more complex biological processors in the future.The researchers hoped biological computers can be applied to monitoring human health in the future.They believed that small biological processors, inserted in human bodies, could roam inside the bodies, monitor the health, and correct any problems they found.These biological logic gates are the most advanced created by scientists. But there is still a long way to go to apply them in reality, said Professor Kitney.

WASHINGTON, Dec. 21 (Xinhua) -- New research suggests that, in people who don't currently have memory problems, those with smaller regions of the brain's cortex may be more likely to develop symptoms consistent with very early Alzheimer's disease.The study was published Wednesday in the online issue of Neurology, the medical journal of the American Academy of Neurology.For the study, researchers used brain scans to measure the thickness of regions of the brain's cortex in 159 people free of dementia with an average age of 76. The brain regions were chosen based on prior studies showing that they shrink in patients with Alzheimer's dementia.Of the 159 people, 19 were classified as at high risk for having early Alzheimer's disease due to smaller size of particular regions known to be vulnerable to Alzheimer's in the brain's cortex, 116 were classified as average risk and 24 as low risk. At the beginning of the study, participants were also given tests that measured memory, problem solving and ability to plan and pay attention. The tests will go on over the next three yearsThe study found that 21 percent of those at high risk experienced cognitive decline during three years of follow-up after the MRI scan, compared to seven percent of those at average risk and none of those at low risk."Further research is needed on how using MRI scans to measure the size of different brain regions in combination with other tests may help identify people at the greatest risk of developing early Alzheimer's as early as possible," said study author Bradford Dickerson, of Massachusetts General Hospital in Boston and a member of the American Academy of Neurology.

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