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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - For the fourth day in a row, San Diego County public health officials Saturday reported a case rate of fewer than 100 positive COVID-19 tests per 100,000 people, however, the state said it will have to review data before removing the county from its monitoring list.Previously, county and state officials had said if the rate stays below 100 per 100,000 people -- it was 94.7 Saturday -- for three consecutive days, the county would officially be removed from that list. After an additional 14 consecutive days below that number, K-12 schools could potentially reopen for in-person teaching, depending on individual school district metrics.Additionally, 48 elementary schools have filed waivers with the county to return to school early.RELATED: What happens next? San Diego County eligible to fall off of California watch listThat timeline is now uncertain, as is the timeline of reopening certain businesses for indoor operations.As the county awaits further guidance from Gov. Gavin Newsom, public health officials reported 279 new COVID-19 cases and four new deaths Friday, raising the county's totals to 34,344 cases and 626 deaths.One woman and three men died between July 5 and Aug, 13, and their ages ranged from the late 50s to late 80s. All had underlying medical conditions.Of the deaths reported thus far during the pandemic, 96% had some underlying medical condition. According to Dr. Wilma Wooten, the county's public health officer, the leading underlying causes, which helped contribute to the deaths, were hypertension, diabetes, heart disease, dementia/Alzheimers and chronic kidney disease.RELATED: Coronavirus test used by NBA players gets FDA approvalOf the 11,268 tests reported Friday, 2% returned positive, maintaining the 14-day positive testing rate at 4.3%, well below the state's target of 8% or fewer. The 7-day rolling average of tests is 7,944 daily.While signs look positive for the region, County Supervisor Nathan Fletcher warned county residents against getting complacent."We are seeing progress, but we are in the middle of a marathon, not a sprint to the finish line right in front of us," he said. "Our goal is not just to have the rate of cases fall below 100 per 100,000, but to keep it there."RELATED: CDC: After COVID-19 recovery, patients are likely unable to spread virus for 3 monthsOf the total positive cases in the county, 2,835 -- or 8.3% -- have required hospitalization since the pandemic began, and 710 -- or 2.1% -- were admitted to an intensive care unit.County health officials also reported two community outbreaks Friday, bringing the number of outbreaks in the past week to 25.The latest outbreaks were reported in a distribution warehouse and one in a health care setting, according to the county Health and Human Services Agency.The number of community outbreaks remains well above the county's goal of fewer than seven in a seven-day span. A community setting outbreak is defined as three or more COVID-19 cases in a setting and in people of different households in the past 14 days.Latinos are still disproportionately impacted by COVID-19, with that ethnic group representing 61.3% of all hospitalizations and 45.4% of all deaths due to the illness. Latinos make up about 35% of San Diego County's population.A new COVID-19 testing site began operating Wednesday at the San Ysidro Port of Entry PedEast crossing, and County Supervisor Greg Cox cited its immediate success and demand for it.The free testing site will operate from 6:30 a.m. to noon Monday through Friday and will focus on testing essential workers and American citizens who live in Tijuana, according to San Diego County health officials.No appointments are necessary at the walk-up site, which aims to offer about 200 tests daily. People getting tested will not be asked about their immigration status or who lives with them, health officials said."We know that communities in South Bay have been hit the hardest by COVID-19," said Wooten. "The location was selected because of the increase in cases in the region and the number of people, especially essential workers who cross daily." 4143

SAN DIEGO (CNS) - A San Diego federal judge largely upheld California's private prison ban in a ruling stemming from dual lawsuits filed against the state by the Trump administration and a private prison firm.U.S. District Judge Janis Sammartino issued a preliminary injunction Thursday upholding in most respects Assembly Bill 32, which took effect Jan. 1 and prohibits the operation of private detention facilities statewide.By 2028, the law would bar all inmates from being held at privately owned facilities. The law also prohibits agencies from entering into new contracts for privately owned detention facilities or renewing existing contracts at currently operating facilities.The federal government and private prison firm The GEO Group argued that the law is unconstitutional because it encroaches on the government's operations to house federal inmates by unlawfully allowing a state government to regulate federal operations.Additionally, the government has argued that private facility closures will force the relocation of thousands of inmates at high cost to taxpayers, with inmates also forced to be incarcerated at greater distances from their families, especially if they are relocated out of state.The GEO group alleges that it will lose around 0 million per year in revenue if forced to close down its California facilities and could lose more billion in capital investment and revenue over the next 15 years.Sammartino ruled that AB 32 is a regulation of private detention contractors rather than the federal government and its operations and disagreed with plaintiffs' arguments that AB 32 interfered with congressional objectives to house detainees in private facilities, except in respect to United States Marshals' detainees.Sammartino wrote, "Congress clearly authorized USMS to use private detention facilities in limited circumstances, such as where the number of USMS detainees in a given district exceeds the available capacity of federal, state and local facilities."As AB 32 would prevent the use of private facilities when no available space exists in other facilities, she preliminarily enjoined enforcement of the ban in regards to USMS detainees, but it remains in effect for the U.S. Bureau of Prisons and ICE.According to court papers, 1,100 USMS inmates in California are housed in private detention facilities, representing about 22% of USMS statewide.Among those inmates, many are housed at San Diego facilities that include the Metropolitan Correction Center, Western Region Detention Facility, and Otay Mesa Detention Center.The United States and the GEO Group can file amended complaints within the next three weeks, according to Sammartino's order. 2706

SAN DIEGO (CNS) - A motorist who fled from officers near Hoover High School Wednesday led police on a meandering, roughly 45-minute road chase, running stoplights and driving the wrong way on one-way streets before pulling over near Lindbergh Field and making a failed attempt to escape on foot.The man drove off when patrol personnel approached him at about 12:15 p.m. to check on his welfare in response to a report that he appeared distraught while sitting in a white Chevrolet Malibu parked in the 4400 block of El Cajon Boulevard in the Teralta East area, according to San Diego police.The fleeing motorist, whose name was not immediately available, traveled over various mid-city streets before heading west on University Avenue through City Heights, North Park and Hillcrest.Early on in the chase, the driver ran over a spike strip laid out by police in his path, winding up with at least one flat tire on his car, Officer Tony Martinez said.After crisscrossing streets near Scripps Mercy Hospital, the man -- who appeared to be talking on a cellphone throughout the pursuit -- headed south on Fifth Avenue, driving against light traffic on the one-way northbound thoroughfare.Reaching downtown San Diego, the motorist crisscrossed the busy urban center for about 15 minutes, often driving at slow speeds, blowing through red lights and traveling in the wrong direction on one-way streets as police cruisers and an SDPD helicopter tailed him and officers placed more spike strips ahead of him.Eventually, he proceeded west through the Cortez Hill and Little Italy districts on B Street, then north on Pacific Highway, at one point driving onto a sidewalk to evade the pursuing police personnel.Just after 1 p.m., the fleeing man drove into a car-rental lot near San Diego International Airport, pulled over, jumped out of his vehicle and ran off into a parking garage.Officers gave chase and got the man into custody following a brief struggle, police said.No injuries were reported. 1998

SAN DIEGO (CNS) - An Animal Planet TV series focusing on the San Diego Zoo and the zoo's Safari Park will premiere Saturday, offering audiences a behind-the-scenes view of the zoo's daily activities."The Zoo: San Diego" will debut with two one-hour episodes titled "Welcome to Our World" and "New Day for an Old Tortoise." The series will follow animal care staff members, veterinarians, scientists and researchers at the zoo, Safari Park and the zoo's Institute for Conservation Research.The first episode will feature a baby klipspringer's birth and first days at the zoo, research into why a species of pit viper is having spinal issues and conservation work on the California condor population. The Safari Park will also host a celebration for Joanne the gorilla's fifth birthday.RELATED: Southern White rhino calf, Edward, gets a mud wallow at San Diego ZooThe second episode will focus on the zoo's tortoises and koalas as well as the hand-rearing of two giraffe calves at the Safari Park. According to the zoo, the 10-part series will focus more on conservation than captivity.We know that this compelling program will not only delight and engage viewers, but will also provide a global platform for us to share incredible stories of the conservation efforts that our organization has undertaken to ensure the survival of endangered species, San Diego Zoo ambassador Rick Schwartz said when the series was announced in April."The Zoo: San Diego" will premiere at 8 p.m. on Animal Planet. On Aug. 17, the series will move to its normal scheduled time at 9 p.m.Check out the teaser for the series: 1610