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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) — San Diego Police are searching for the driver involved in a fatal hit-and-run in Mountain View last month.Police say 81-year-old Ruben Mendez was walking in a crosswalk at the intersection of South 45th St. and Logan Ave. on June 30 just before 7:30 p.m. An unknown, silver-colored vehicle was turning left onto Logan Ave. when it collided with Mendez. The vehicle then headed eastbound in the 4700 block of Logan Ave., police say.The vehicle did not stop to check on Mendez before fleeing the scene, police added.Mendez sustained major injuries and was taken to a nearby hospital. On July 1, he died of his injuries.Investigators are asking anyone with information on the crash or suspected vehicle involved to call SDPD’s Traffic Division at 858-495-7807 or Crime Stoppers at 888-580-8477. 818

SAN DIEGO (KGTV) - San Diego County Congressman Duncan Hunter spoke Tuesday morning to a group of women who support him despite accusations that he and his wife misused campaign funds.“Women Volunteers in Politics” gathered for the speech at the Bali Hai restaurant on Shelter Island. The event was booked months before Rep. Hunter’s indictment.Hunter spoke to 10News before the event.“Leave my wife out of it, leave my family out of it. It’s me they’re after anyway. They’re not after my wife; they want to take me down, that’s what they’re up to. So let’s get this in the arena and have this settled,” said Hunter.Tuesday's statement was a change from Hunter's message the morning after the indictment was announced. When asked about the accusations levied against his wife, Hunter confirmed that she was in charge of campaign expenses but added, “That’ll come out in court. That’s for the court and for her.”DUNCAN HUNTER INDICTMENT: 949

SAN DIEGO (KGTV) - San Diego County is home to some of the most infamous houses in the country, with many deemed notorious because of the grisly murders, mysterious suicides, and eerie accidents, that have taken place there. 232

SAN DIEGO (KGTV) - San Diego Police are looking for more possible victims of a Balboa Park street performer suspected of multiple sexual assaults. Luis Martinez-Haaz, 22, was arrested May 3 in relation to several open cases from April, officers said.Police said Martinez-Haaz worked as a street performer and dancer in Balboa Park, and would often approach women after his shows. He convinced them to walk to isolated areas where he would sexually assault them, investigators said. San Diego Police Sex Crimes Unit detectives are searching for any additional victims or people with information related to the cases. Martinez-Haaz is 5’7” and 145 pounds with short brown wavy hair. He is currently in custody on 0,000 bail. 733