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SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) -- Authorities are investigating a man's death after they say he died following a fight. Police were called to the 5600 block of Imperial Avenue in Valencia Park around 1:12 p.m. after receiving reports of a man having chest pains. After arriving, the 51-year-old man -- identified as San Diego resident Joseph Ives -- was taken to the hospital where he later died.Police later learned that Ives got into a fight shortly before his death. According to police, after an altercation with another man, Ives told a witness that he was experiencing chest pains. Ives "did not have any obvious signs of trauma to his body," police said. Out of caution, San Diego Police homicide detectives are investigating the death.  773

SAN DIEGO (KGTV) — As county leaders struggle to control the latest surge of COVID-19 in San Diego, there is an acknowledgment that there are no good options. While many businesses are preparing to ignore public health orders to close or limit operations, public health experts warn the consequences of failure to limit the spread of the virus will be dire.“The reality of it is indoor spaces with people talking without masks are not safe. I think that’s really important to getting this under control,” said Dr. Rebecca Fielding-Miller, an expert in infectious diseases at UC San Diego.She says the county has tried to chart a middle course between allowing businesses to remain open while trying to rein in the virus. “We have been, I’m really sorry to say, doing it in half measures since March," Fielding-Miller said.But to be successful, such a policy requires a great commitment by the public to safety measures such as wearing masks, social distancing, and avoiding gatherings. That commitment has proven vulnerable to the COVID fatigue felt by the public, as adherence to those measures tends to slide with time.Fielding-Miller says some counties in the United States, along with some other countries, have had success with brief but strict lockdowns. However, there may not be public support for such actions here.Others advocate a full reopening of the economy and letting the virus run its course. They argue that the economic, psychological, and educational harm from the public health restrictions are greater than the damage caused by the virus itself. Proponents say the United States should try a “herd immunity” strategy, where attempts are made to protect vulnerable populations, but the virus is otherwise allowed to spread unchecked through the general population. The theory projects that once enough people are infected, the virus has nowhere left to spread and will die out on its own.Most public health experts say that method could prove catastrophic. They point out that it’s not known how many people would have to be infected, but it would have to be a majority. “If we went down this path where we attempt to infect 70% of the population, the very, very likely outcome is we would end up with something like one to two million Americans dying,” said Fielding-Miller. Furthermore, it is also not known how long a person is immune after recovering from COVID-19. There have already been cases of people being infected for a second time. “We would end up with extraordinarily high rates of disability and mortality for no gain at all, for people to just be able to get reinfected in six months. So I understand the attraction, but it's also not viable," Fielding-Miller said.This week, San Diego moved into the purple tier, the most restrictive of California’s COVID-19 tiers. 2811

SAN DIEGO (KGTV) — California public health officials said Friday that the state's ICU capacity dropped dangerously low, prompting warnings to take the latest regional stay-at-home order seriously.The Office of the Governor announced on social media that, "there is less than 10% ICU capacity remaining statewide. We are at a critical moment. Calling all Californians - stay home & wear a mask to save lives. All hands on deck with our health & emergency teams as we address the capacity crisis."The state also broke a single-day record for new COVID-19 cases with 35,468 cases on Friday, and reached a new high in hospitalizations, with 12,013 patients, and ICU cases, at 2,669, Los Angeles ABC affiliate KABC said.RELATED: San Diego hospitals lay out plans to distribute vaccines to staffFriday, the state's COVID-19 data showed California's ICU capacity at 9% and a seven-day average 8.4% positivity rate. The Southern California region, which includes San Diego County, currently sits at 6.2% ICU capacity. The figures, however, don't necessarily give a real-time picture of staffed beds available since the state adjusts the percentage based on the ratio of COVID-19 positive and non-coronavirus patients.California's regional stay-at-home orders covered 36 counties, or about 77% of the state, as of Friday.Friday, FDA officials are expected to approve Pfizer's coronavirus vaccine for distribution. According to the CDC, front line medical workers are among the first set to receive the vaccination. 1522

SAN DIEGO (KGTV) — County law enforcement officials say overdose deaths from fentanyl have sharply increased since last year.The San Diego County District Attorney Office said in the first six months of 2020, there have been 203 fentanyl-related deaths: 119 have been confirmed and 84 are pending confirmation. The victims range in age from 17 to 66 years old.In all of 2019, there were 152 fentanyl-related overdose deaths in the county."This alarming uptick demonstrates that dealers continue cutting various illegal drugs with fentanyl and now more than ever it’s a recipe for death," said District Attorney Summer Stephan. "The public needs to be aware of the danger of using any controlled substance even if packaged like a harmless medicinal pill. Higher overdose numbers tell us there’s likely more product on the street in San Diego that may be laced with deadly fentanyl. I’m urging you to share this potentially life-saving message with your loved ones today."The DA's office says it is prosecuting several cases, including: In January, a 28-year-old smoked a powdery substance given to him by a friend. His mother found him unresponsive in the living room of her home. He was pronounced dead from a fentanyl overdose.In February, a 20-year-old suffering from anxiety, consumed a counterfeit oxycodone pill before going to bed. His roommates found him dead in the morning from a fentanyl overdose.In May, a 19-year-old purchased two Percocets from a friend. He consumed both pills and subsequently died from an overdose. He had fentanyl in his system at the time of his deathFentanyl is a synthetic opioid that is 50 to 100 times more potent than morphine and up to 50 times more potent than heroin, according to officials. Even in doses as little as two milligrams, the drug is lethal for most people. Treating fentanyl overdoses often requires additional naloxone, the drug used to reverse opioid overdoses, to reverse the effects of the drug.Anyone who is need of help with drug addiction can call the San Diego County Access and Crisis Line 888-724-7240 or 2-1-1 San Diego at any time daily. 2113

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