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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

Those tuning in to watch baseball today might have some extra trouble picking out their favorite player.That's because April 15 marks Jackie Robinson Day, a day in which every Major League Baseball team will honor the first player to break the sport's color barrier after decades of segregation.As part of the celebration, all uniformed personnel in the MLB — players, coaches and umpires — will wear No. 42 for today's games.Robinson made his debut with the Brooklyn Dodgers on April 15, 1947. He was the first black player to play professional baseball in the 20th century — before that, there was a racist agreement among team owners to keep black ballplayers off the field.Not only was Robinson a pioneer in civil rights, he was one of the greatest baseball players of his era, and was enshrined in the Hall of Fame upon his retirement. 852

The owner of a Chevrolet dealership in Jefferson City, Missouri where a tornado hit Wednesday says the storm destroyed more than 500 cars.“I just can’t believe it,” Riley Chevrolet and Toyota general manager Jay Schnieders said. “They were tossed around like toys.” 277

The owners of Maximum Security, the horse that was disqualified at the Kentucky Derby, have filed a federal lawsuit, seeking to overturn the disqualification.The horse led the derby from wire to wire and crossed the finish line 1 3/4 lengths ahead of Country House but was disqualified for interference while turning for home. Stewards decided that Maximum Security impacted the progress of War of Will, which in turn interfered with Long Range Toddy and Bodexpress.The lawsuit, filed Tuesday in US District Court for the Eastern District of Kentucky, challenges the evidence and process used to disqualify Maximum Security. The suit claims the disqualification violated the plaintiff's right to due process because they could not appeal. The stewards "abused their discretion," the lawsuit says.Gary and Mary West, who own the 3-year-old colt, are seeking the reinstatement of the original order of finish."The insubstantiality of the evidence relied on by the Stewards to disqualify Maximum Security, and the bizarre and unconstitutional process to which Plaintiffs were subjected before and after the disqualification, are the subjects of this action," the lawsuit said.Maximum Security's owners and jockey Luis Saez "were denied any part of the ,860,000 share of the Derby purse as well as a professional accomplishment that any horseman would cherish for life, plus the very substantial value that a Kentucky Derby winner has as a stallion," the lawsuit said.The lawsuit names the Kentucky Horse Racing Commission, its members and the stewards as defendants.Susan West, a spokeswoman for racing commission, declined to comment on pending litigation.Country House was declared the winner. Chief steward Barbara Borden read a statement to the media after the ruling -- which said Maximum Security had veered out of his path -- but took no questions.After interviewing jockeys and watching video for nearly 20 minutes, all three stewards agreed to penalize Maximum Security."Despite the fact that no objection had been lodged by the owner, trainer, or jockey of War of Will or Bodexpress, the Stewards unilaterally determined that Maximum Security had committed a foul and then lied to the public that they interviewed the "affected riders" when they knew they did not interview War of Will's jockey, Tyler Gaffalione, nor Chris Landeros, Bodexpress's rider," the lawsuit said.Maximum Security was the "leading horse," the lawsuit said, meaning the colt is "entitled to any part of the track."Last week, the state commission last week swiftly denied Maximum Security's appeal of the disqualification, saying the stewards' decision is not subject to appeal, because there is no right to appeal a disqualification under Kentucky lawOn Sunday, the 2761

The suspect accused of carrying out Friday's terror attack in Christchurch, New Zealand, was likely on his way to carry out a third shooting before he was stopped by authorities, New Zealand's top police official said.Fifty people were killed when a gunman opened fire inside two mosques last week. Authorities have charged Brenton Tarrant, a 28-year-old Australian man, with murder in connection with the incident. More charges are expected.Police Commissioner Mike Bush said Wednesday that authorities "absolutely" believe they stopped the suspect "on the way to a further attack.""Lives were saved," he added, but declined to go into detail to not "traumatize others."The first funerals were held Wednesday for Khaled Mustafa, 44, and his son, 15-year-old Hamza.Hundreds of people stood in solemn silence at Memorial Park Cemetery, where graves had been dug to bury dozens of victims.New Zealand Prime Minister Jacinda was back in Christchurch to offer comfort to those affected by the tragedy.She said at a news conference that the country will broadcast the Islamic call to prayer Friday on TV New Zealand and Radio New Zealand in support of the country's Muslim population."There's a sense among New Zealanders that they wish to show to the Muslim community their support, their love," Ardern said at a news conference Wednesday."But the challenge for all of us going forward is that they're safety is assured by making sure we never have an environment where violent extremist ideology can flourish. And that means addressing racism and extremism wherever it emerges.""Why do I not know what you're doing to identify the bodies?"While many family members have expressed understanding about the time it is taking to receive victims' bodies for burial, others have voiced frustration. Islamic funerals typically are held as soon as possible after death.Mohamed Safi, 23, lost his father in the attack at the Al Noor mosque. He said the authorities have not explained their process for identifying his father's body and have been slow to offer details."They're offering nothing, they're saying, 'We're doing our procedures and process.' Why do I not know what you're doing to identify the bodies?" Safi told CNN."They know that our Islam is about patience. They're testing our patience right now," Safi said.At the same news conference, Bush said that the identification process was "an absolute priority for family reasons, compassionate reasons and for cultural reasons."Ardern said she shared the frustrations voiced by the victims of loved ones, but also noted that authorities were under significant strain due to the number of victims.She said 30 of the victim's bodies have been identified and approved for release."I know the process has been incredibly difficult, frustratingly slow from the perspective of family members, but on the (other) side, I've seen those who are working on this process as well and I can also acknowledge that they are working incredibly hard too," Ardern said.'Darkest days'On Tuesday, Ardern had used 3054