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There is no God -- that's the conclusion of the celebrated physicist Stephen Hawking, whose final book is published Tuesday.The book, which was completed by his family after his death, presents answers to the questions that Hawking said he received most during his time on Earth.Other bombshells the British scientist left his readers with include the belief that alien life is out there, artificial intelligence could outsmart humans and time travel can't be ruled out.Hawking, considered one of the most brilliant scientists of his generation, died in March at the age of 76."There is no God. No one directs the universe," he writes in "Brief Answers to the Big Questions.""For centuries, it was believed that disabled people like me were living under a curse that was inflicted by God," he adds. "I prefer to think that everything can be explained another way, by the laws of nature."Hawking suffered from amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder also known as Lou Gehrig's Disease, for most of his adult life.The scientist died while still working on the book, which his family and colleagues finished with the help of his vast personal archives.'Increasingly looking inward'While Hawking spoke of his lack of belief in God during his life, several of his other answers are more surprising."There are forms of intelligent life out there," he writes. "We need to be wary of answering back until we have developed a bit further."And he leaves open the possibility of other phenomena."Travel back in time can't be ruled out according to our present understanding," he says. He also predicts that "within the next hundred years we will be able to travel to anywhere in the Solar System.""He realized that people specifically wanted his answers to these questions," the scientist's daughter, Lucy Hawking, who helped complete the book, told CNN.Hawking saw the world on the brink of a "vast transformative change" when he died, she noted, adding: "He's asking us not to go into the future blindly. How good is the track record of the human race in using advances in technology for the good of ordinary people?"In remarks prepared by Hawking and played at the launch of the book in London on Monday, the scientist also turned his attention to the world he was leaving behind."With Brexit and Trump now exerting new forces in relation to immigration and the development of education, we are witnessing a global revolt against experts, and that includes scientists," Hawking said.Hawking had been a critic of the United Kingdom's decision to leave the European Union, and called Donald Trump a "demagogue" in 2016.His greatest concern, his daughter said, "is how divided we've become," adding: "He makes this comment about how we seem to have lost the ability to look outward, and we are increasingly looking inward to ourselves."Hawking's final message to readers, though, is a hopeful one.Attempting to answer the question "How do we shape the future?" in the book's final chapter, the scientist writes: "Remember to look up at the stars and not down at your feet." 3096

Three restaurants associated with celebrity chef Mario Batali will be closing in Las Vegas.Batali has been accused of sexual misconduct. He has denied any wrongdoing. RELATED: TV chef Mario Batali under police investigation for sexual misconductEmployees of Carnevino Italian Steakhouse, B&B Ristorante and Otto Enoteca e Pizzeria received notification Friday morning. All three restaurants are located at The Venetian/The Palazzo. The restaurants will close July 27. A letter written by Joe Bastianich with B&B Hospitality Group says that Las Vegas Sands Corp. decided to end the relationship. The letter also says that the group will help employees transition into new positions. An earlier report said that B&B was "actively negotiating" to buy out the celebrity chef.Batali stepped down from daily operations of his restaurant empire and his cooking show after the allegations surfaced in December. Four women accused him of touching them inappropriately.    1022

There’s a new trend online, and it’s making people money. But shoppers don’t even know what they’re purchasing.They’re called “Mystery Boxes” and the products are popular on sites like Etsy and eBay."We order stuff on Amazon all the time, but we know what we're getting, says Aurelia Seward, a seller on Etsy.“How much funner would it be to get a box and not know what’s inside of it?”  Seward sells all-natural holistic items and has been curating mystery boxes for about a month."My mystery boxes can be any array of items to handcrafted jewelry to real gem stones for healing,” she explains. “Lava stone bracelets for diffuser oils, essential oils, stuff like that."  Buyers can choose from all sorts of themed boxes, including electronics, toys, beauty products, etc.Seward’s boxes sell for .   "I haven't been doing too much marketing for them, but the orders are rolling in, so that's kind of fun.Some boxes can go for 0, but Seward cautions buyers to watch out for the more expensive ones."I've seen some that are really big duds,” she says. “Like, they have gotten dirty clothes.”Buyers should also check the seller’s reviews before purchasing a mystery box. 1200

The year 2020 was unlike any other, with so much uncertainty and new challenges. The world responded by asking “why”, according to the top global Google searches this year released this week.The search platform says “why” questions were searched more in 2020 than in any other year. With questions like “why can’t I sleep,” “why social distancing,” and “why is it called COVID-19.”Google says “insomnia” was searched globally more in 2020 than ever before.Here in the U.S., the uncertainty of the election, coronavirus and the economy drove a lot of the search inquiries. Google separated results based on general topics in their annual report. The top five news-related searches were “election results,” “coronavirus,” “stimulus checks,” “unemployment,” and “Iran,” with “stock market” and “murder hornet” also making the top ten.And people wanted more information, with questions like “coronavirus symptoms,” “COVID-19 testing sites near me,” and sarching the definitions of “pandemic,” “Juneteenth,” and “asymptomatic.”Americans also went to Google to find how to keep themselves busy during the coronavirus pandemic, with queries like “recipes for Sourdough bread,” “how to cut men’s hair at home,” “dating during coronavirus,” “how to make a mask,” “where to buy toilet paper,” and searches for “virtual field trips” and “virtual museum tours.”Joe Biden was the top person Americans typed into Google search, followed by Kim Jong Un, Kamala Harris, Jacob Blake and Ryan Newman.Searches for Tom Hanks and Kobe Bryant were also high on Google’s list; Hanks contracted COVID-19 earlier this year and Bryant died tragically in a helicopter crash in January.People were also moved to help. Searches for “how to help Black Lives Matter,” “how to help during coronavirus,” “how to donate blood,” and “how to help someone having a panic attack” were four of the top “how to” inquiries on Google search. 1907

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676