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The U.S. will pay drug company Pfizer .95 billion to produce and deliver 100 million doses of the company's COVID-19 vaccine candidate should the drug prove effective in human trials the company said in a press release on Wednesday.Pfizer will deliver the vaccine if and when the drug receives Emergency Use Authorization from the FDA after a large-scale Phase 3 trial.According to the reports, the deal includes an option for the government to purchase an additional 500 million doses of the vaccine.“Expanding Operation Warp Speed’s diverse portfolio by adding a vaccine from Pfizer and BioNTech increases the odds that we will have a safe, effective vaccine as soon as the end of this year,” Health and Human Services Sec. Alex Azar said in a statement. “Depending on success in clinical trials, today’s agreement will enable the delivery of approximately 100 million doses of this vaccine to the American people.”Pfizer and German firm BioNTech are working together to develop the vaccine.On Monday, Pfizer said in a press release that results from Phases 1 and 2 of a German trial indicated that the drug "could potentially be administered safely, with a manageable tolerability profile," according to data from the tests.Biotech company Moderna is also working to develop a coronavirus vaccine. That candidate will move into Phase 3 testing by the end of the month, and the government has also agreed to purchase and distribute the drug should the large-scale test prove effective. 1497

The recommended amount of sleep for adults is six to eight hours a night. Sleeping more than those hours is associated with an increased risk of death and cardiovascular diseases, says a global study published Wednesday in the European Heart Journal.Looking at data from 21 countries, across seven regions, the research team found that people sleeping more than the recommended upper limit of eight hours increased their risk of risk of major cardiovascular events, like stroke or heart failure, as well as death by up to 41%.But a possible reason for this could be that people have underlying conditions causing them to sleep longer, which in turn could raise the risk of cardiovascular disease or mortality, explain the authors of the study.The team, led by Chuangshi Wang, a Ph.D. student at McMaster and Peking Union Medical College in China, also identified a rising risk among daytime nappers."Daytime napping was associated with increased risks of major cardiovascular events and deaths in those with [more than] six hours of nighttime sleep but not in those sleeping [less than] 6 hours a night," Wang said.In those who underslept, "a daytime nap seemed to compensate for the lack of sleep at night and to mitigate the risks," Wang explained.Previous studies into this topic were mainly carried out in North America, Europe and Japan. The new study brings a global picture.But the findings are observational, meaning the cause of this association remains unknown."Even though the findings were very interesting they don't prove cause and effect," said Julie Ward, a senior cardiac nurse at the British Heart Foundation, who was not involved in the study.Having less sleep -- under six hours -- was also shown to increase these risks by 9%, compared with people who slept for the recommended six to eight hours, but this finding was not considered to be statistically significant by the team.In 2014, 35.2% of American adults reported not getting enough sleep with less than seven hours per night, according to the CDC. 2049

The reboot of "Lizzie McGuire," which was to air on Disney+, is no longer happening.Actress Hilary Duff, who played the lead on the original Disney Channel series that ran from 2001 to 2004, announced on social media Wednesday that the reboot wouldn't happen despite everyone's best interests.In 2019, Disney announced they were relaunching the show. According to The Hollywood Reporter, after several delays, including the firing of creator and revival showrunner Terri Minsky, grounded production after they'd already shot two episodes.Original cast members Adam Lamberg, Hallie Todd, Robert Carradine, and Jake Thomas were set to reprise their roles as well, Variety reported.According to CNN, Duff made a public plea in February asking the series be moved to Disney-owned Hulu from Disney+ so that the show could be a more adult-friendly version. 858

The revolution is coming. The much-anticipated video premiere of “Hamilton” will be available on Disney+ Friday, July 3.Here are the details: The video is 2 hours and 41 minutes long, and includes a minute countdown for intermission. It was recorded using several cameras during two of the last performances of the initial 2016 Broadway run of the hit musical, and includes most of the original cast.It will only be available on the Disney+ streaming service starting at 12 a.m. PT/3 a.m. ET on Friday. Disney is holding a Twitter watch party later in the day at 7 p.m. ET/4 p.m. PT. 591

The woman had used oxycodone for almost a decade but told her doctors she had been sober for two years. She never touched narcotics during her pregnancy, she said, and had completed rehab.But her newborn son was in withdrawal: jittery, screaming and requiring an infusion of morphine to stay alive. The infant craved drugs, but why?Amid an opioid epidemic, the boy's doctors didn't blame heroin, fentanyl or other illicit substances. Instead, they said, the infant had grown dependent on a controversial herbal supplement: kratom. 538