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CORONADO, Calif. (KGTV) — An iconic Coronado bookstore says it is being forced out after 27 years at its home on Orange Avenue. Bay Books employees say landlord Kleege Enterprises has found a new tenant for the site and that it has to be out by March."I'm obsessed with this bookstore," said manager Barbara Chambers. "I don't know what I'm going to do."Building owner Bruce Kleege says this is not the case. He said he believes negotiations with the bookstore are ongoing and that he would like to keep the bookstore, albeit smaller. Last year, Kleege's company bought almost the entire block of buildings on Orange Avenue, the bookstore included, for million. Already, two high-end restaurants and a poke restaurant are on the way, replacing previous tenants. Kleege says the bookstore is paying a fraction of market rent, a gap that needs to narrow, but not close.Meanwhile, bookstore owner Angelica Muller says some of the spaces offered are off the main street, half the space, and double the rent to about ,000 a month. That's a rate she says an independent bookstore can't afford.Kleege says he is willing to work with the bookstore and wants to continue to negotiate. 1190

Coronavirus pandemic safety measures have more Americans spending the traditionally family-and-food centric holiday of Thanksgiving in smaller groups or alone.If this is your first time attempting the big meal on your own, here are some basics and places to get help and advice.First figure out how much meat you’ll need, before you buy whatever turkey is left at the grocery store. Consider roughly one pound per person, this accounts for bone weight when buying the turkey. If you like a lot of leftovers, consider 1.5 pounds per person.If it’s just you and maybe one or two others, consider buying just a turkey breast. They are usually a few to several pounds each and are all white meat.You could also opt for a whole chicken instead; they are smaller but still give you the full bird experience with light and dark meat, legs, and a wishbone to snap.Before moving on, you should probably consider if you are comfortable cooking a turkey (or chicken) from raw. If not, that’s ok. Plenty of restaurants and grocery stores have done the cooking for you and will gladly deliver or have you pick up Thanksgiving meals for any size group.Once you have the right amount of meat, keep it frozen until a few days before you want to cook it, and then move it to the fridge to thaw.For what comes next, there are so many options for preparing and cooking a turkey, it’s hard to pick one way. While most agree the stuffing should not actually be stuffed inside the raw turkey, there are other questions - Foil on or off? Grill, oven or crockpot? Brine or no brine? Oil or butter?For help, step-by-step instructions, and ideas, here are some helpful links:10 Tips for cooking the perfect turkey from the Food NetworkBetty Crocker: How to cook a turkeyHow to cook a turkey, from the New York TimesPillsbury claims to have a no-fail methodAnd of course, there is the Butterball Hotline. A Thanksgiving tradition for first-time chefs across the country for almost four decades.The hotline has been answering chef’s questions since 1981. There is likely no turkey question they haven’t been asked before.Butterball offers turkey tips and tricks over the phone, by text message, live online chat, email and even through Amazon Alexa. And yes, they are helpful no matter what brand of turkey (or chicken) you are cooking.After all this work for the main dish, consider enjoying pre-packaged or heat-and-serve side dishes at Thanksgiving.If you are feeling adventurous and want to make sides, here are some helpful links:85 classic Thanksgiving side dishes from Delish - including sweet potatoes with marshmallows, green bean casserole, cranberries, and homemade cornbread.Best Thanksgiving side dishes from Good Housekeeping - including glazed carrots, buttermilk biscuits, squash soup, and rosemary rolls.Best of all, some of them can be made ahead and heated on Thanksgiving.Leaving you more time to explain to your extended family how to unmute themselves on your family Zoom call. (FYI, Zoom is lifting its 40-minute limit on free calls on Thanksgiving.) 3053

CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735

Considered the coronavirus holy grail, antibodies are believed to give us some level of immunity from the virus. They form after a person fights off COVID-19 and can be detected through a serological test, better known as an antibody test. "There are some really great companies building antibody tests, and there are some not so great, bad actors, building antibody tests. So you have to be really careful," says Jon Carder, co-founder and CEO of Vessel, a San Diego company created four years ago to provide in-home wellness tests. Early in the pandemic, the U.S. Food and Drug Administration allowed these tests to be sold and distributed without federal review, as long as the company notified the FDA it was offering a test, performed self-validation studies, and included a disclaimer on the test results. The FDA is now cracking down on the bad actors, creating a list of tests that should no longer be distributed. Only a handful of manufacturers have been granted FDA Emergency Use Authorization, meeting a certain threshold for accuracy.Carder says states and even countries have been fooled by the bad actors, purchasing inadequate tests. "We were talking to a city government, a big city, and were blown away when we got a response that they were thinking about buying antibody tests from a certain manufacture who had claimed they were FDA approved. And the state had sort of taken their word for it, and they weren't," said Carder. Vessel had been preparing to release its in-home wellness tracker, which tests for health markers like vitamins, minerals, toxins, and cortisol. When the pandemic hit, the company adapted its technology to be used in the fight against COVID-19. "We take existing antibody tests, the good ones, the ones that are accurate and that the FDA has approved for emergency use, and we enable those to be done safely and accurately at home," said Carder. They've created a kit with step-by-step instructions to do the blood test at home. The test card is then scanned through the Vessel app and provides results from a medical professional within a half-hour. The FDA has already approved in-home tests to diagnose active infections – but Carder says the sample must be sent to a lab, and the user must have symptoms or another qualification to get one. And he says they can be costly. "Ours could be one of the first, or the first, antibody test done at home, no lab needed," said Carder. Just this week, the FDA issued three warning letters to companies making false claims on their in-home antibody tests.Vessel has completed its usability studies and is now in clinical trials with the FDA. "Our job is to prove it can be done safely at home and to show that via clinical trials. The FDA really makes the call if they're going to enable antibody testing at home," said Carder. He says the test would be cost-effective, anywhere from -, or around with medical consultation. If approved by the FDA, Carder estimates millions of people could be tested within the first few months. "There's something really great about the peace-of-mind that comes from doing a test, and that may be one of the biggest benefits," said Carder. But while the FDA is only approving the most accurate tests, none are 100 percent accurate and could still lead to false positives. 3314

CINCINNATI – The E.W. Scripps Company (NASDAQ: SSP) is acquiring Triton, the global leader in digital audio technology and measurement services, helping Scripps advance its strategies for near- and long-term value creation.Triton serves the growing digital audio marketplace through a software-as-a-service (SaaS) business- to-business revenue model. Triton powers or measures streaming music and podcasting for many of the biggest names in audio, including Pandora, Spotify, NPR, iHeart, Entercom, Cumulus, Prisa (Spain), Mediacorp (Singapore) and Karnaval (Turkey).Triton’s infrastructure and ad-serving solutions deliver live and on-demand audio streams and insert advertisements into those streams. Triton’s data and measurement service is recognized as the currency by which publishers sell digital audio advertising.Financial highlights include:? The purchase price is 0 million. 901