普宁看白癜风最好的中医(治疗白癜风普宁哪里最好) (今日更新中)

Juan Rodriguez is living every parent's worst nightmare. In the past 48 hours, his 1-year-old twins died after he forgot them in a car for eight hours in temperatures that reached unimaginable levels in the car and in the mid-80s outside.The 39-year-old father was arrested and charged with two counts each of manslaughter, criminal negligent homicide and endangering the welfare of a child, the New York Police Department said.His attorney, Joey Jackson, told CNN when he went to see his client Saturday, he looked "inconsolable and beside himself." 563

KANSAS CITY — Maureen Boesen has always known cancer risk was high in her family."We're able to really track our history of breast cancer back to the late 1800s and early 1900s," Boesen said. "My grandmother actually passed away from ovarian cancer when she was 44. She had five sisters and none of them lived to the age of 50. Then, my mother was diagnosed with breast cancer when she was 32. We knew there was something going on and that it was a very young age."When Boesen and her two sisters were ages 3, 5 and 7, their mom was already receiving chemotherapy for stage 2 breast cancer. Because of the extensive family history, the girls were part of a study at a university in another part of the Midwest. Their mom was hoping to help the world better understand what was killing so many women. She was hoping to better her daughters' chances for survival."We were all tested in the same exact room," said Boesen's sister, Bridget Stillwell. "I can even remember what the room looked like." Because the girls were so young, and the health threat still likely years away, they wouldn't receive their DNA test results until they turned 18."We knew we were part of a study," Boesen said. "We knew our results were waiting for us, but we didn't know what they were."When asked if she found that wait frustrating, she said emphatically it was not."Quite the opposite. We felt empowered," she said.She didn't get the results right away. The sisters knew there was nothing they could likely do at age 18 even if their test results showed they'd inherited the BRCA gene mutation. The sisters all waited until they were around age 21. One sister was positive. One sister was negative. Boesen remembers meeting with the researcher to learn her results."We sat down and we had a conversation about what BRCA was and what it meant for my family," Boesen said. "It was a lengthy conversation, which made me very uncomfortable because why would a conversation that wasn't going to change my life last that long?"Eventually, the researcher told her she had inherited the gene mutation."It was just devastating because I knew what breast cancer and ovarian cancer can do to a family. You know, my first question out of my mouth was, 'Is there any chance this could be wrong?' The researcher said 'No.' "Boesen walked out of that meeting determined. She was going to make decisions to save her own life. She was going to have a bilateral prophylactic mastectomy. She would schedule a surgery to remove both breasts to prevent breast cancer."This was me doing what I was supposed to do and this was me being empowered and me being proactive and not waiting until I have a cancer diagnosis," Boesen said.She didn't want to feel like a ticking time bomb. She wanted to live.Boesen had the surgery to remove both breasts when she was just 23 years old. She went on to get married and have three children."I didn't get to breastfeed them. It was sad. I'm not brokenhearted or devastated about it, but it is sad to think I couldn't provide for my children like that," she said.At the time, she still believed she'd made the right decision because she was healthy.Once done having children, she knew there was another step that most people with the dangerous BRCA gene mutation have to consider."I knew that when I was done having children, I needed to have a complete hysterectomy," Boesen said.The BRCA gene mutation not only dramatically increases a woman's chance of developing breast cancer at a young age, it also significantly increases a woman's chance of ovarian cancer."The right thing to do and what the doctors say to do is have a complete hysterectomy by the age of 35 and I was in my early 30s," Boesen said.In 2018, she went to a hospital in Kansas City, Missouri, to start the process of preparing for her hysterectomy. Both her health care provider and her insurance company wanted a new DNA test. Everyone knew what the results would be, but they went through the motions to get the required confirmation she was positive for the deadly gene mutation which was so rampant in her family.The test results were supposed to be back in a few weeks, but it had been four and Boesen was starting to worry. Then, she got the call from the doctor."I was at work. And the first thing she said was, 'We need to talk', and my heart just sank," Boesen said. "She said, 'You're negative,' and I just started bawling."She was overwhelmed, confused and full of emotions."I was angry. I was regretful. I was happy. I was sad. I so desperately wanted to feel relief, 'Oh, thank God, this is the best day of my life,' but it wasn't," Boesen said. "It was just devastating."Boesen got another test to confirm the second test results. It also came back negative.She did not get the hysterectomy. There was no need now. There was no longer a threat that cancer was waiting to explode in her body. She now knew she had not inherited the BRCA gene mutation that had killed so many of her relatives.Dr. Jennifer Klemp of the University of Kansas Cancer Center has worked in the field of cancer genetics, specifically breast and female cancers, since 1997. She is the director of Cancer Survivorship and a cancer risk counselor. While she was not involved in Boesen's original research, she says she's not surprised."Twenty years ago, when we sent our first tests and BRCA 1 and 2 were the two genes we tested for, about 30-40 percent of the time we would get something called a 'variant of uncertain significance,' " Klemp said. "Basically, that meant we found a mutation or an error in the DNA, but we didn't know if that was associated with an increased risk of cancer. Today, using a reputable lab, that should be less than 1-2 percent."Klemp says things are changing rapidly in the field of genetic testing. If someone had a DNA test more than five years ago, they should consider having an updated test. She also says the at-home tests are good for finding out details about your ancestry, but they shouldn't be used to make major decisions about your health. For that, you'd want a health professional to order a commercial test through a certified, reputable lab. With more and more companies offering testing, and more medical professionals and patients interested in genetic testing for so many reasons, she says demand right now is outpacing supply."If you have 10 different labs doing testing, and you have every primary care, OB-GYN, oncology clinic, surgical clinic and any number of patients eligible for testing, it's a little bit of the wild west," Klemp said, adding there's no central repository for this patient and test information.As for Boesen, the university where the original research was done and the false positive originated offered to re-test her DNA. She is currently waiting on the results from what is now her fourth genetic test. She hopes it comes back negative, too, which is what the experts all expect. She believes, then, finally, she'll be able to move forward with her life. Boesen and her two sisters are writing a book about their experiences. Each of her sisters has a story to tell, too. Their book will be titled, " 7146

Imagine trying to take a photo of an orange that's on the moon with your smartphone. It seems impossible.That's what it was like for scientists trying to capture an image of a black hole in space. Despite the tall order, an international team of more than 200 researchers unveiled the 297

Jeffrey Epstein's death ends the criminal case against him, but his powerful friends and associates may not have heard the last of it.US Attorney for the Southern District of New York Geoffrey Berman said the investigation of Epstein's alleged conduct, including a conspiracy charge, remains ongoing, and Attorney General Bill Barr similarly said the case will continue against anyone who was complicit with Epstein."Any co-conspirators should not rest easy. The victims deserve justice and they will get it," Barr said.In addition, Epstein's accusers asked a federal judge on Monday to invalidate the non-prosecution agreement that Epstein reached with prosecutors in the US Attorney's Office in Florida a decade ago, which would give authorities "greater power" to go after his alleged co-conspirators.Given that ongoing investigation, CNN took a look at the notable figures connected to Epstein who have been named in sworn testimony, as well as the major political figures with ties to him.Unnamed assistantsThe federal indictment against Epstein says that he ran a trafficking enterprise in which he sexually abused dozens of underage girls between 2002 and 2005 at his homes in Manhattan and Palm Beach, Florida. He also paid some of his victims to recruit other victims, the document states.He was charged with sex trafficking of minors and conspiracy to engage in sex trafficking of minors, and he had pleaded not guilty to the charge.The indictment specifically alleges Epstein worked and conspired with employees and associates who facilitated his conduct by, among other things, contacting victims and scheduling their sexual encounters with him.The roles of three employees are laid out in the indictment, though they are not personally identified."Employee-1," based in New York, was directed by Epstein to communicate with victims to arrange their visits to his New York City mansion, the indictment says. This employee also sometimes asked the victim-recruiters to bring a specific underage girl for Epstein, the indictment states."Employee-2" and "Employee-3" were both assistants who worked for Epstein and both were also responsible for scheduling sexual encounters with victims ahead of his visits to his Palm Beach residence, according to the indictment.It's unclear why the assistants were not named in the documents.Other unnamed employees have similarly been noted in a draft version of a lawsuit that was expected to be filed by Jennifer Araoz, who said she was raped by Epstein when she was 15.CNN usually does not name possible sexual misconduct victims, but is identifying Araoz because she came forward to speak publicly on a television news program and is named in the lawsuit draft.Her draft complaint targeted Epstein as well as unidentified women called the "Recruiter," the "Secretary" and the "Maid," whom it dubs Jane Does 1, 2 and 3. The draft complaint said that the recruiter facilitated her "grooming" to be sexually assaulted by Epstein, and that the secretary and the maid would give her money after her visits to Epstein.Ghislaine MaxwellA series of documents unsealed last week accuse Ghislaine Maxwell, the British daughter of the late publishing tycoon Robert Maxwell, of assisting Epstein in his sexual abuse.At the heart of the documents are allegations Virginia Roberts Giuffre made in a 2015 defamation case. Giuffre said Epstein kept her as a "sex slave" and that he was assisted by Maxwell. Testimony from another woman in those documents also alleged abuse at the hands of Epstein and Maxwell.The case was settled in 2017.An attorney for Maxwell did not respond to CNN's request for comment on Friday. Maxwell and her representatives have previously denied she engaged in sexual abuse or sex trafficking.In the court filings, Maxwell and her attorney portray Giuffre as an unreliable narrator, pointing to errors in certain dates and figures she provided. Giuffre has said the errors were mistakes.David Boies, an attorney for Giuffre, said Friday that her lawsuit "exposed for prosecutors, and now the public, the scope and scale and ugliness of the Epstein/Maxwell sex trafficking ring."Les WexnerEpstein's longtime associate was Les Wexner, the CEO and founder of L Brands, the parent company of Victoria's Secret and Bath & Body Works. After Epstein's arrest on federal charges last month, Wexner acknowledged that Epstein was his former personal money manager and that he served as a trustee of the Wexner Foundation, the CEO's charitable group.He said he severed ties with Epstein 12 years ago and denied knowledge of his criminal behavior."I would never have guessed that a person I employed more than a decade ago could have caused such pain to so many people," Wexner wrote in a letter to L Brands employees. "My heart goes out to each and every person who has been hurt."Their connections ran deep, and Wexner gave Epstein "sweeping powers over his finances, philanthropy and private life," 4969

Justin Bieber supports President Donald Trump's decision to help rapper A$AP Rocky, who is currently in the custody of Swedish police. But the "What Do You Mean" singer thinks others could benefit from the President's attention, too.Bieber said on Twitter late Friday he appreciated the President lobbying Swedish authorities on behalf of the rapper. Earlier Trump had said his administration was working to resolve the matter."I want my friend out," 463

来源：资阳报