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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) -- At least one person died in a Bay Park crash as rain soaked the roads in San Diego County Sunday morning. According to California Highway Patrol, the crash happened just before 6 a.m. Sunday on northbound Interstate 5 just before Clairemont Drive. CHP reports that the vehicle was traveling at high speeds just before the crash. At least three vehicles were involved in the crash. According to CHP, the driver of a pickup truck crashed into the center divide before being struck by two other vehicles. The driver of the truck was standing outside his vehicle when he was hit and killed by one of the vehicles. The driver was 48-year-old Joseph Vito Berardino, according to the medical examiner. At this time, it’s unclear how many more people may have been injured. 794

SAN DIEGO (KGTV) — As Seaworld San Diego reopens its doors this weekend, an East County grandmother and passholder says she and her grandson won't be making a visit.Visiting SeaWorld is one of Rose Becker's favorite things to do with her 4-year-old grandson Vincent."He just loves walking around and looking at the dolphins, orcas, and sea lions," said Becker.So when SeaWorld announced they would be reopening, she got excited.RELATED: Several San Diego County businesses to reopen indoors with limits under new guidance"I was planning on taking him Sunday. Was so excited to hear SeaWorld was back open. My grandson was so excited ... and then my excitement, down to frustration," said Becker.She was frustrated because of the cost. SeaWorld is opening through its weekend Zoo Days Bayside BBQ and Brews events. It's reservation only with a limited capacity. The park's attractions will be limited to outdoor animal exhibits and shows. A ticket will include food, drink, and merchandise. Passholders like Becker get a complimentary ticket but must pay for the lanyard for the food and beverages. She would receive a more-than-50% discount, but Becker still has to shell out for Vincent and herself, a cost she can't afford.RELATED: North County leaders join Legoland to demand state give direction for businesses to open"I'm retired and on a limited income ... I'm very frustrated and angry that I can't take my grandson to go visit SeaWorld, when it's open to the public who wants to pay for a special ticketed event, and not to us who have been paying all this time as passholders," said Becker.She's not alone. In the past few days, ABC 10News has received emails and Facebook messages from passholders upset about having to pay for the extra cost."We're being treated like second class citizens in essence," said Becker.SeaWorld plans to hold the weekend events until late September, and then reassess a true opening. The park has announced it will be extending expiration dates for passholders and upgrading them to the next tier of benefits. 2061

SAN DIEGO (KGTV) - At least one person is dead after a collision in Sorrento Valley early Saturday.A field of debris marked the site of the collision on northbound Interstate 5 at the I-805 connector. California Highway Patrol officers the crash included a white Toyota Tacoma and a red Honda.The driver of the Honda died at the scene. CHP officials said they believe that person was driving the wrong way and may have been under the influence of alcohol - multiple beer cans were found in the vehicle.The driver of the Toyota was taken to a nearby hospital with serious injuries. Officials said  He was in his truck with his dog at the time of the crash. The man's dog was taken to a nearby animal hospital, though its condition is not known.RELATED: Updating San Diego traffic conditionsA motorcycle seen in the wreckage was originally in the bed of the pickup truck, according to CHP officials.Three lanes on I-5 were shut down while crews investigate and clean up the scene 1010

SAN DIEGO (KGTV) -- Authorities are searching for a felony traffic violator in Mission Valley who drove onto trolley tracks while fleeing from police during a chase Sunday morning. Police say officers tried to pull over a vehicle on Hotel Circle shortly before 9 a.m. because the vehicle didn’t have a front license plate.During the chase, the suspect failed to stop and ran several lights at high speeds. Police also say the driver drove the wrong way during the pursuit. RELATED: Fatal shooting leads to standoff between police, suspect in North ParkPolice used spike strips, prompting the driver to stop and flee the scene on Fenton Parkway and Friars Road near Costco.The suspect is believed to be hiding out in the Del Rio Apartments.  768

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