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The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722

The terms "signing bonus: and "recruiting" are usually reserved fro top-paid professional athletes. Now add nurses to that list.Hospitals across the country are facing a shortage of nurses, and they're stepping up the incentives to fill the jobs.Patients aren't the only ones happy that Christina Predo is working at UCHealth. After all, the hospital gave her a ,000 signing bonus as an incentive to take the job."Other offers before that hadn't even come close," Predo said.Predo needed to find a job where her husband was being relocated. With several offers on the table, in the end it was UCHealth's signing bonus and other perks that sealed the deal."They offered all sorts of help to help move here," Predo said. "They offered someone to actually find me a neighborhood to live in which was awesome. None of the other hospitals actually offered to do that."What's behind the big bonuses? A shortage of nurses. With more than 500,000 seasoned registered nurses expected to retire by 2022, there's a projected need for 1.1 million new nurses to avoid a shortage.Hospitals across the country, including UCHealth, are feeling that crunch already."Well I'll tell you what, we have about 300 positions open," said Kathy Howell, Chief Nursing Executive at UCHealth.Howell says growth has created a greater demand for nurses, and a good economy means more nurses are opting to retire. That's why there's a concerted effort to make the offer to work at UCHealth as attractive as possible, even allowing out-of-state nurses to try out the hospital for a year and covering their housing costs."They go from assignment to assignment within our health system," Howell says. "We also give them a housing stipend, and we usually convert between 35 and 40 percent of them to full-time employees."Most new nurse hires get around ,000 to sign, which Howell doesn't think is out of line."When you look at what turnover of nurses costs and what not having the right nursing complement is to your hospital," Howell says. "That is a very reasonable investment."Ultimately, Howell says it's about delivering the right care to patients, and creating the right environment for the nurses they hire."It's a real comradery. Everyone is super super nice, you really have a say in what you're doing here, your opinion actually matters you don't feel like a number," Predo said.A new way to fill the need for nurses, with a payoff, multifold. 2476

The Senate voted to send Brett Kavanaugh to the Supreme Court on Saturday, ushering in a generational conservative majority and delivering a huge victory to President Donald Trump after a vicious confirmation battle inflamed by allegations of sexual assault against the nominee.As shrieks of "shame, shame, shame" echoed from the public galleries, divided and angry senators voted 50-48 to endorse a lifetime seat on the court for Kavanaugh. The protests underscored the vital importance of an appointment that will have sweeping consequences for some of the nation's most contested disputes over abortion, LGBT rights, the scope of presidential power and the role of religion in society.Hours later, Kavanaugh was sworn in at a private ceremony. Chief Justice John Roberts administered the constitutional oath and retired Supreme Court Justice Anthony Kennedy administered the judicial oath, according to the Supreme Court.The bitter fight over Kavanaugh now moves into the epicenter of the campaign for the midterm elections in November. Republicans are convinced it will motivate their sleepy base. Democrats believe a backlash against the GOP from women voters could help deliver the House of Representatives. And the nature of the fight over Kavanaugh will trigger recriminations inside the Senate and political reverberations outside for years to come.In the end, Republicans were able to use their stranglehold on Capitol Hill and the White House to muscle through the confirmation in a power play that reflected the momentous importance of Trump's 2016 election victory over Hillary Clinton.Still, it was a close-run thing: Kavanaugh's nomination was nearly derailed by Christine Blasey Ford's allegations that the judge assaulted her when they were teenagers in the 1980s, which sparked uproar and forced Republicans to delay the confirmation vote for a week to allow time for a supplemental FBI background check.Trump's first exuberant response to the vote came in a tweet as he flew to Topeka, Kansas for a campaign rally that is likely to become a raucous victory lap."I applaud and congratulate the U.S. Senate for confirming our GREAT NOMINEE, Judge Brett Kavanaugh, to the United States Supreme Court. Later today, I will sign his Commission of Appointment, and he will be officially sworn in. Very exciting!Kavanaugh will be sworn in as an associate justice of the Supreme Court on Saturday by Chief Justice John Roberts and the man he will replace, the Court's crucial swing vote, Anthony Kennedy.Democrats furiously accused the GOP of short-circuiting efforts to examine Ford's allegations and of rushing the nomination through while ignoring the changed political dynamics surrounding complaints of misconduct against powerful men ushered in by the #MeToo movement.Senate Minority Leader Chuck Schumer called the nomination "one of the saddest moments in the history of the Senate," and said, "this chapter will be a flashing red warning light of what to avoid."Republicans "conducted one of the least transparent, least fair, most biased processes in Senate history, slanting the table from the very beginning to produce their desired result," he added.Majority Leader Mitch McConnell described Kavanaugh as a "superstar."McConnell, who stalled Barack Obama's nomination of Merrick Garland to the court in his final year in office and for whom the new conservative majority represents a defining achievement, predicted that Democratic tactics during confirmation battle would electrify Republican voters in November."They managed to deliver the only thing we had not been able to figure out how to do, which is to get our folks fired up," McConnell said. "The other side is obviously fired up, they have been all year."Kavanaugh's confirmation leaves the Senate traumatized with Republicans and Democrats as estranged as at any time in recent memory, reflecting the cavernous divides in the country itself during a presidency that has ignited rare political passions.It represents the culmination of a decades-long project by the conservative movement to construct a like-minded majority on the Supreme Court which has been a defining and unifying cause in successive congressional and presidential campaigns.The new profile of the court immediately makes Trump a consequential president, for all of the chaos and discord that rages around his White House, and means his legacy will include an achievement that eluded previous Republican presidents -- all of whom had more authentic conservative credentials.The ferocious nature of the confirmation battle could also have an impact on the Court itself, as Kavanaugh's vehement and politicized defense of his own behavior raised questions about his temperament and whether he could genuinely be an honest broker and implementer of the law in the most sensitive cases. 4844

The Weinstein Company, the studio co-founded by disgraced movie mogul Harvey Weinstein, has filed for bankruptcy and torn up legal contracts that kept sexual harassment victims from speaking out.The company said late Monday that it will release victims of, and witnesses to, Weinstein's alleged misconduct from any non-disclosure agreements."Effective immediately, those 'agreements' end," the company said in a statement. "No one should be afraid to speak out or coerced to stay quiet," it added.The Weinstein Company was crippled by the sexual harassment and assault allegations first made against Weinstein last year.Now the studio has reached a deal with the private equity firm Lantern Capital Partners. Lantern is looking to acquire Weinstein Co. through the bankruptcy process.The initial bankruptcy paperwork was filed on Monday night."While we had hoped to reach a sale out of court, the Board is pleased to have a plan for maximizing the value of its assets, preserving as many jobs as possible and pursuing justice for any victims," Bob Weinstein, Harvey Weinstein's brother and chairman of the company, said in a statement provided to CNNMoney.Other bidders could come forward and try to top Lantern's bid for the Weinstein Co. assets.The filing estimates the Weinstein Co. businesses are valued between 0 million and billion.New York Attorney General Eric T. Schneiderman had been pushing for this outcome for several months."This is a watershed moment for efforts to address the corrosive effects of sexual misconduct in the workplace," Schneiderman said Monday night. "The Weinstein Company's agreement to release victims of and witnesses to sexual misconduct from non-disclosure agreements -- which my office has sought throughout this investigation and litigation -- will finally enable voices that have for too long been muzzled to be heard."To date, dozens of women have accused Weinstein of abuse, following reports in the New York Times and the New Yorker last year about his treatment of women, including some of those with whom he's worked. Weinstein has been accused of rape, assault and other forms of sexual misconduct.He sought treatment after the allegations were made public. Through a representative he has repeatedly denied allegations of "non-consensual sex."Monday night's press release from the company said Weinstein Co. "regrets that it cannot undo the damage Harvey Weinstein caused, but hopes that today's events will mark a new beginning."The bankruptcy filing came after a deal to sell the studio's assets fell apart earlier this month.An investment group led by Maria Contreras-Sweet, the former head of the U.S. Small Business Administration, had been close to acquiring all of the company's assets for 0 million but negotiations fell apart at the last minute.Schneiderman's office had been helping to mediate the deal talks.Schneiderman's civil suit against Weinstein Co., Bob Weinstein, and Harvey Weinstein remains active and the investigation is ongoing, his office said Monday.The bankruptcy was announced on the same day New York Gov. Andrew Cuomo directed Schneiderman to review the Manhattan district attorney's handling of a 2015 sexual abuse case involving Weinstein.This week's New York magazine features a story questioning why D.A. Cyrus Vance Jr. hasn't prosecuted Weinstein.Time's Up, the female-led organization formed in the aftermath of the Weinstein scandal, responded to the story by calling for a probe into Vance and his office "to determine the facts related to the decision not to prosecute Harvey Weinstein for sexual abuse crimes against one of his accusers, Ambra Battilana."Back in October, The New Yorker?released an audio recording of Weinstein speaking with young model Ambra Battilana Gutierrez as part of a 2015 sting operation. The NYPD set up the sting after Gutierrez told authorities that Weinstein groped her the day before.In the recording, Weinstein makes potentially incriminating comments to Gutierrez, but he was not arrested or charged with a crime at the time.After the tape's release, the New York Police Department and the Manhattan DA's office traded public finger-pointing. But on Monday, Vance and the NYPD released a joint statement reiterating their shared commitment to investigate and prosecute sexual assault cases.Vance has also faced criticism for accepting a ,000 donation from David Boies, an attorney who has represented Weinstein, in August 2015, according to campaign financial disclosure forms from the New York State Board of Elections.Vance's office said Monday that "our investigation of Mr. Weinstein is active and ongoing."That response didn't seem to satisfy Cuomo. He answered Time's Up's call and referred the matter to Schneiderman's office, instructing the A.G. to review Vance's handling of the Battilana case "in a way that does not interfere with the current investigation..."Schneiderman welcomed the opportunity, saying, "We are committed to pursuing a full, fair, and independent review of this matter."The-CNN-Wire 5076

The United States and Mexico have reached an agreement to change parts of NAFTA, the trade deal that President Donald Trump has derided for years as unfair.Trump announced the agreement from the Oval Office Monday, with Mexican President Enrique Pe?a Nieto dialed in on a conference call.But the deal left open the question of whether Canada, the third country in NAFTA, would agree to the changes -- and Trump himself said he wanted to throw out the name NAFTA altogether."They used to call it NAFTA," Trump said. "We're going to call it the United States-Mexico trade agreement. We're going to get rid of NAFTA because it has a bad connotation."Negotiators for both countries agreed to a new rule that dictates where auto parts are made.Under the current law, about 62 percent of the parts in any car sold in North America must be produced in the region or automakers have to pay import taxes. The new preliminary agreement would require that 75 percent of auto parts be made in the United States and Mexico, according to the U.S. Trade Representative's office.Much of the business world has been worried about Trump's trade policies, and the stock market reacted positively to the news. The Dow rose more than 250 points and the S&P 500 and Nasdaq hit new highs on Monday.The agreement between the two countries could restart negotiations on NAFTA with all three parties -- the United States, Mexico and Canada.Despite Trump's signal that the deal could lead to a bilateral trade agreement between the United States and Mexico, Pe?a Nieto, through a translator, expressed his "desire that now Canada will also be able to be incorporated in this."Mexico and Canada have stood firm on the importance of maintaining the trilateral format of the NAFTA free trade deal, even as Trump has signaled a desire for individual deals with each country."Canada is encouraged by the continued optimism shown by our negotiating partners," said a spokesperson for Canadian Minister of Foreign Affairs Chrystia Freeland."Progress between Mexico and the United States is a necessary requirement for any renewed NAFTA agreement," he said.Negotiations on rewriting the three-country NAFTA agreement began about a year ago.The 24-year-old trade agreement generally prevents the three parties from imposing tariffs on imports from one another. But Trump has called the agreement "the worst deal maybe ever signed" and moved ahead with tariffs earlier this year.In May, the United States imposed steep tariffs on steel and aluminum from much of the world, including Mexico. In response, Mexico slapped tariffs on billion of U.S. goods, including steel, pork, apples, potatoes, bourbon and different types of cheese. Canada imposed tariffs on .5 billion of U.S. goods, including steel, toffee, maple syrup, coffee beans and strawberry jam. 2841

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