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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CAMP PENDLETON, Calif. (KGTV) — A brush fire on Camp Pendleton sent heavy smoke into the air above Oceanside Tuesday.Residents reported seeing heavy smoke in the North County from the base. Camp Pendleton officials say the fire closed Stewart Mesa Rd., between Donald Cook and the 41 Area, at about 1:30 p.m.The blaze reached 18 acres before fire crews stopped its forward progress just before 2 p.m. No personnel or structures were threatened, according to the base.The brush fire ignited as the region endures elevated fire danger, with gusty offshore winds in the mountains and foothills and humidity hovering between 15 and 25 percent. 647

CHARLOTTE COUNTY, Fla. -- A Polk County, Florida man is pleading for a thief to return a sentimental wedding gift that was stolen out of a family member's truck in Port Charlotte.Boomer Bass left for a fishing trip on Little Gasparilla Island last week, and thought it was best to leave his Springfield 1911 Range Officer Gun with a family member, rather than bring it with him.On April 19th, Bass's mother reported that the gun was stolen out of his truck in the Water's Edge neighborhood in Englewood. The gun holds sentimental value to Bass. "I had a gun very similar to this one when I was younger," he said. "I sold it to help a friend of mine out, and I really regretted selling that gun." With this in mind, his wife, Stefanie, made the decision to buy him that same gun on the morning of their wedding. They married in October of last year. "She went and bought that gun for me and gave it to me that night at our wedding reception, actually," Bass said. "I think the gun signified, really, that she understood the generosity I showed when I was younger, and she wanted to show me she would be the kind of wife that would do those things for me."Stealing a gun is a felony in the state of Florida. However, Bass says if the thief wants to return his gun, he would accept it with no questions asked. "Hopefully, you feel like you made a mistake. I will not prosecute, I will not pursue any legal action. All I want is this gun back," he said. Bass said he is willing to pay the retail price for a brand new gun if his is returned safely. It is a Springfield 1911 Range Officer with wood grips, night sights, blued finish, serial # NM502637. "I'm begging you...to anyone else, this is just a gun," he said. "But to me, it means more than I can even put into words."If you have any information that could help lead Bass to his sentimental wedding gift, or you are in possession of it, he asks that you contact him directly on Facebook at Boomer Bass.  2039

CASA DE ORO (CNS) - A person was found dead today under suspicious circumstances in a residential neighborhood near Mount Helix.The fatality in the 4400 block of Carmen Drive in Casa De Oro was reported shortly before 1:30 p.m., according to sheriff's officials.After deputies confirmed the death, homicide detectives were called in to take charge of the investigation, Lt. William Amavisca said.Further details about the case, including the victim's identity and cause of death, were not immediately available. 519

CARLSBAD, Calif. (KGTV) -- If "Toy Story" were real, it might have looked like Sue and Stephen Stewart's rooftop."I thought a few people would notice, but no, they now come by constantly," described Sue Stewart.It all started when Sue and her husband Stephen wanted to bring smiles and joy to their neighborhood amid COVID-19, while they worked from home."He saw something on the internet similar and he thought this is what I'm gonna do. He ordered all of them and then we had to figure out 'How am I going to get them up on the roof?'"Little did they know their small investment would equal something big."I went to get the mail and these people go, 'That is the best thing ever.' You have no idea what an impact he's making. He's making people smile," Sue said about her husband's work.Kids weren't the only ones eager to get a glimpse of their favorite characters."It's couples, it's adults. There's two ladies that walk by every single day and check it out every single day."Every other week was a different scene and sometimes, someone new."We didn't have the aliens so we got the aliens and moved them one time. We moved the position of Buzz and Woody and got Little Bo-Peep in," Sue described.They moved the figurines safely with fishing line. Sue said they chose Toy Story because of it's message that we're all in this together. 1346

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