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The study asked 116,632 adults between the age of 35 and 70 from 21 countries about their sleeping habits. Participants were then followed up over an average of 7.8 years.The team found that for every 1,000 people sleeping the recommended six to eight hours per night, 7.8 developed cardiovascular disease or died each year. This rose to 9.4 in people who slept six or fewer hours a night.Francesco Cappuccio, professor of cardiovascular medicine and epidemiology at Warwick University, who was not involved in this study, has done several studies into sleep and its effect on our health. He says that a lack of sleep is "definitely associated with an increased risk of death.""If you sleep less for a long time you are more prone to develop chronic disease," Cappuccio said, adding that short sleep duration has been shown to increase high blood pressure, obesity and diabetes.However, the findings for those who underslept were not found to be statistically significant, and the greatest risk was instead seen among those who overslept.For those sleeping eight to nine hours, 8.4 per 1,000 people developed cardiovascular disease or died each year. This rose even further in those sleeping nine to 10 hours (10.4 per 1,000) and again among those sleeping more than 10 hours (14.8 per 1,000).This equates to an increase in risk of a 5%, 17% and 41%, respectively, compared with people who slept the recommended amount of hours.But Wang pointed out that too much sleep could be a marker for other causes of cardiovascular diseases and death.Cappuccio agreed, adding that "it's not that long sleep causes death or ill health" but that ill health will cause you to sleep more.Cappuccio mentioned that people who have an undetected illness may suffer from an extension of sleep. If someone has an underlying cancer, for example, they will be more fatigued and debilitated and will tend to sleep longer.The study's main takeaway is that the optimal duration of estimated sleep is six to eight hours per day for adults, Wang explained.It is "very important to point out that there are some very simple things you can do to help you sleep better at night," Ward said, advising people to avoid caffeine in the afternoon or evenings, as well as alcohol and nicotine, which can disrupt sleep patterns. Exercise and a balanced diet can help, she added. 2352

The Veterans Home of California and all its programs, including The Pathway Home, are an important part of the Napa Valley Community, with the 1,200-seat Lincoln Theater, a golf course and a large library, the California Department of Veterans Affairs said. 257

The transformation of 7% of Scott's DNA suggests longer-term changes in genes related to at least five biological pathways and functions.The newest preliminary results from this unique study of Scott, now retired from NASA, were released at the 2018 Investigator's Workshop for NASA's Human Research Program in January. Last year, NASA published its first round of preliminary results at the 2017 Investigator's Workshop. Overall, the 2018 findings corroborated those from 2017, with some additions.To track physical changes caused by time in space, scientists measured Scott's metabolites (necessary for maintaining life), cytokines (secreted by immune system cells) and proteins (workhorses within each cell) before, during and after his mission. The researchers learned that spaceflight is associated with oxygen-deprivation stress, increased inflammation and dramatic nutrient shifts that affect gene expression.In particular, Chris Mason of Weill Cornell Medicine reported on the activation of Scott's "space genes" while confirming the results of his separate NASA study, published last year.To better understand the genetic dynamics of each twin, Mason and his team focused on chemical changes in RNA and DNA. Whole-genome sequencing revealed that each twin has more than expected unique mutations in his genome -- in fact, hundreds.Although 93% of Scott's genetic expression returned to normal once he returned to Earth, a subset of several hundred "space genes" remained disrupted. Some of these mutations, found only after spaceflight, are thought to be caused by the stresses of space travel.As genes turn on and off, change in the function of cells may occur. 1676

The structure will be the first of its kind in San Diego. The concept has worked well elsewhere, like in Orange County where 16 homes were created using recycled shipping containers. Copley and Holmes tell us their project can be constructed in about three months and at a low price. “Right now, we're projecting 0,000 per unit,” says Copley. 345

The woman, identified as black and 30 years old, suffered a gunshot wound to her upper body and was taken to UC San Diego Medical Center, but she died from her injuries, police said. 182