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JAPATUL VALLEY (CNS) - A fire that has blackened 17,665 acres in rural eastern San Diego County remains at 87% containment Sunday, authorities said."Fire activity was minimal overnight as firefighters continue to mop up hot spots and secure the fire perimeter," according to a U.S. Forest Service news statement. "Structure defense remains a priority for values at risk. Every day the fire stays within its current perimeter, the threat to the adjacent communities continues to diminish. High pressure over Southern California will result in a warming trend into the middle of the week."The Valley fire, southeast of Alpine, has destroyed 30 residences and 31 outbuildings, damaged 11 other structures and injured three firefighters.RELATED: Resource event gets Valley Fire victims back on their feetFire activity was limited Saturday as firefighters continued to mop up hot spots and secure the fire perimeter, officials said. A high-pressure system was expected to keep temperatures high through the rest of the weekend.At noon Friday, Cal Fire announced that all evacuations and road closures necessitated by the conflagration, dubbed the Valley Fire, had been lifted.Saturday morning, the county announced the reopening of the Lake Morena and Potrero campgrounds that had been closed during the evacuation orders. Campsites were available to book at http://reservations.sdparks.org.However, the Cleveland National Forest remained closed to the public until further notice "to protect natural resources and provide for the safety of the public and firefighters," Cal Fire advised.RELATED: Valley Fire claims Jamul woman's home, beloved animals"This closure will stay in place until conditions improve and we are confident that national forest visitors can recreate safely," officials with the state agency said.The blaze erupted for unknown reasons early Sept. 5 off Spirit Trail and Carveacre Road and spread rapidly through tinder-dry vegetation amid sweltering heat and high winds, Cal Fire officials said.The agency cautioned those returning to the fire-ravaged area to "use extreme caution around trees, power poles and other tall objects or structures that may have been weakened" by the blaze.The San Diego County Sheriff's Department was increasing its patrols in the area to ensure public safety and prevent looting.Officials advised that motorists in the area could face traffic disruptions due to the continued presence of firefighters, law enforcement personnel and utility workers still in the area.Non-residents were asked to avoid locales in and around the burn zone if possible.About 140 San Diego Gas & Electric customers in Alpine, Barrett Lake, Dehesa, Lyons Valley and Rancho Palo Verde lost power during the fire fight.Due to smoke drifting over much of the San Diego region, the county Pollution Control District advised that the air quality might be unhealthy in some local communities and advised people to limit outdoor activities until conditions improve.Gov. Gavin Newsom declared a state of emergency for San Diego County on Sunday Sept. 6 due to the Valley Fire, a move intended to free up federal relief funds.County officials encouraged people who have lost their homes or other property to the wildfire to call for assistance at 858-715-2200 or email valleyfirerecovery.@sdcounty@ca.gov.Additionally, a county assistance center for victims of the blaze will be in operation at Rancho San Diego Library, 11555 Via Rancho San Diego, on Saturdays and Sundays from 10 a.m. to 6 p.m. and Mondays from 11 a.m. to 7 p.m. until further notice.Those who would like to help victims of the fire can make donations to a disaster-relief fund implemented by the San Diego Foundation, which can be accessed online at sdcountyrecovery.com. 3770
LA JOLLA, Calif. (KGTV) - A researcher at UC San Diego just got a million grant to further his work into nanosponge therapy.Liangfang Zhang, a professor of nanoengineering and bioengineering, has been working on creating macrophage cellular nanosponges, tiny particles covered in white blood cell membranes, to treat sepsis and other diseases."They can be used to bind to the virus and neutralize the virus," Zhang says. "So now the virus would lose the ability to infect the host cells."The nanosponges act as decoys, tricking a disease or virus into binding with them instead of with human cells. While the initial aim is to treat sepsis, Zhang says it has applications to other deadly diseases, including COVID-19."The formulation that we're developing for treatment of Sepsis is the same formulation that you will use with COVID-19," he says.The grant comes from CARB-X, a Boston-based medical philanthropy that specializes in funding research into antibacterial treatments. Zhang says the money will be used for his company, Cellics Therapeutics, to further advance the research into clinical trials, FDA approval, and production of the nanosponge therapy.Steve Chen, president and chief medical officer of Cellics Therapeutics, says he's hopeful they can advance the nanosponges into human trials within two years."We're essentially looking at how this platform can treat not just infectious disease or future pandemics, but you could actually have a lot of applications in any type of autoimmune diseases or any type of inflammatory diseases," says Chen.In an early study published this year, Zhang's research showed the nanosponges were around 90% effective at blocking infections from taking hold.RELATED: UC San Diego researchers testing nanosponges to fight COVID-19Chen says the research and trial period may take too long for the nanosponges to be used during the current coronavirus pandemic. But he's hopeful it will help make the next outbreak less severe."My sincere desire is that we are not going to need this for COVID-19. But I think this does position us very well for any potential future kind of viral outbreak," says Chen.Cellics is also working on a Red Blood Cell version of their nanosponges, which may be ready for human trials within a year. 2283

JUPITER, Fla. — Groundbreaking research out of the Scripps Research Institute in Jupiter, Florida found a genetic explanation for the pain processing and sensory issues some children living with autism face."To see the biology in the lab turn out that has parallels to what’s going on in these children takes it so far beyond just an academic endeavor," said Dr. Gavin Rumbaugh, a neuroscientist at Scripps. "You go home every day thinking, unbelievably, I may actually be making a difference in someone's life."One of those children who Rumbaugh hopes to help with his research is 10-year-old Beckett, who lives in Texas."We wanted to understand generally in the lab how genes like SYNGAP1 affect the way the brain functions and we thought what better way was then to look and see how this gene may directly affect sensory processing, and then further on ask the question, 'Does the change in sensory processing actually lead directly to learning, memory and behavioral impairment?' " he said.Beckett has a genetic mutation of SYNGAP1, which researchers have now found causes certain issues he faces, particularly, having an extremely high pain threshold while also experiencing heightened sensitivity to another kind of stimuli. Beckett and other children living with this genetic mutation also often have epilepsy."It's all about quality of life. Everybody deserves to live their best life and that's my mission," said Monica Weldon, Beckett's mom.Weldon said the research being done in Jupiter could change her son's life and the lives of hundreds of other children around the world with the same genetic abnormality and symptoms, some of whom whose families she's connected with online."That is the power I believe of a patient group that is motivated to find treatments for their loved ones," Weldon said. "Also, you've got scientists who are listening. They're willing to listen and they're willing to learn."The next step in Rumbaugh's research is to look at treating the symptoms from the genetic mutation. 2043
John Boehner is heading for the boardroom of a cannabis company, the former Speaker of the House announced Wednesday."I'm joining the board of #AcreageHoldings because my thinking on cannabis has evolved," the Ohio Republican tweeted. " I'm convinced de-scheduling the drug is needed so we can do research, help our veterans, and reverse the opioid epidemic ravaging our communities."Boehner, who served as Speaker from 2011 until his resignation from Congress in 2015, was appointed to the board of advisers at Acreage Holdings, a multi-state cannabis business that aims to "make cannabis available to any patient who can benefit from safe and reliable access."His decision to join the board is a marked shift -- in 2009, Boehner said he was "unalterably opposed" to legalization, according to Bloomberg.Former Republican Massachusetts Gov. Bill Weld is also joining the board. The two said in a joint statement that they believe "the time has come for serious consideration of a shift in federal marijuana policy," specifically citing the drug's use by veterans "to self-treat PTSD, chronic pain and other ailments.""While the Tenth Amendment has allowed much to occur at the state level, there are still many negative implications of the Federal policy to schedule cannabis as a Class 1 drug: most notably the lack of research, the ambiguity around financial services and the refusal of the VA to offer it as an alternative to the harmful opioids that are ravishing our communities," they wrote.The Republican politicians' appointments to the cannabis company come as the current Republican administration has cracked down on state-level marijuana regulations. In January, Attorney General Jeff Sessions rescinded a trio of memos from the Obama administration that had adopted a policy of non-interference with marijuana-friendly state laws.The move essentially shifts federal policy from the hands-off approach adopted under the previous administration to unleashing federal prosecutors across the country to decide individually how to prioritize resources to crack down on pot possession, distribution and cultivation of the drug in states where it is legal. 2177
JUNEAU, Alaska — Health officials in Alaska have reported that a second health care worker had an adverse reaction to a COVID-19 vaccine.Bartlett Regional Hospital in Juneau says the two workers showed adverse reactions about 10 minutes after receiving the vaccine and were treated. One received the vaccine Tuesday and will remain in the hospital another night under observation while the other, vaccinated Wednesday, has fully recovered.U.S. health authorities warned doctors to be on the lookout for rare allergic reactions when they rolled out the first vaccine, made by Pfizer and Germany’s BioNTech. In the U.S., vaccine recipients are supposed to hang around after the injection in case signs of an allergy appear and they need immediate treatment — exactly what happened when the health worker in Juneau.The CDC said it is aware of the incident."Anaphylaxis is a rare event following vaccination and CDC is evaluating the case," the CDC said in a statement. "CDC and public health experts prepared for a side effect like this after reports of anaphylaxis were made in England. Appropriate medical treatment for severe allergic reactions must be immediately available in the event of an anaphylactic reaction occurs, the CDC said. Britain had reported a few similar allergic reactions a week earlier.Allergies are always a question with a new medical product, but monitoring COVID-19 vaccines for any other, unexpected side effects is a bigger challenge than usual.It’s not just because so many people need to be vaccinated over the next year. Never before have so many vaccines made in different ways converged at the same time — and it’s possible that one shot option will come with different side effects than another.Getting either the Pfizer-BioNTech shot or the Moderna version can cause some temporary discomfort, just like many vaccines do.In addition to a sore arm, people can experience a fever and some flu-like symptoms — fatigue, aches, chills, headache. They last about a day, sometimes bad enough that recipients miss work, and are more common after the second dose and in younger people.These reactions are a sign that the immune system is revving up. COVID-19 vaccines tend to cause more of those reactions than a flu shot, about what people experience with shingles vaccinations. 2312
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