郑州杞县眼病医院(郑州眼角膜移植要多少钱) (今日更新中)

Last year's seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, then, people had inadequate protection against the flu.This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a new study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today.This year's flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate professor at the University of Pennsylvania. Add to that, he said, "this could end up being a pretty bad flu season."Still, he said, "our best protection" against severe illness is getting vaccinated with the flu shot we have today.Finding answersEach year before flu season begins, a vaccine is made based on whichever virus strains are expected to circulate. The selected seed strains are distributed to vaccine manufacturers which then produce their formulations and make them available to health care professionals before the season begins.During the 2015-16 season, vaccine effectiveness was 47%, while for the previous 2014-15 season, effectiveness was just 19%, according to the CDC. While the overall effectiveness of last season's vaccine was 42%, it was only 34% effective against the H3N2 viruses that dominated the season.Vaccine effectiveness varies based on how well it matches the circulating virus strains. Sometimes, a vaccine corresponds to the predominant virus yet its effectiveness is still not what scientists would expect. Trying to understand which element of the vaccine failed is difficult.Hensley and his team began their investigation of last year's vaccine by looking at the seed strains that had been distributed to vaccine manufacturers. These seed strains had been propagated in chicken eggs, the common method used today."The sequences of these viruses are available and when we did an alignment to see what the sequence of these vaccines were compared to the viruses that were circulating, it became very obvious that there was this mutation," said Hensley.To see the effects of the mutation, the team next looked at how the immune systems of both animals and humans who'd been inoculated with an egg-based flu vaccine responded to the actual circulating viruses.The antibodies -- immune system proteins that fight invading pathogens -- elicited in both animals and humans failed to bind to and neutralize the flu viruses, Hensley and his colleagues found.While most vaccines in the United States are made in chicken eggs, a small fraction are produced in insects or mammalian cells, Hensley explained. (These are given to people with egg allergies.) He and his team compared immune responses in animals and humans who had received a cell-based vaccine -- in this case, Flublok made by Protein Sciences Corporation."And we found both animals and humans receiving that (cell-based) vaccine had superior antibody responses that could bind and neutralize these circulating H3N2 strains," said Hensley.Making a better vaccine"Most of the infrastructure to produce vaccines in the US is based on chicken eggs," said Hensley. There are good reasons for this, including the fact that egg-based propagation allows manufacturers to quickly produce large quantities of vaccine.While egg adaptations have always been a problem, beginning last year it had become a "huge problem," said Hensley. "As soon as you try to grow this virus in eggs, within a few hours, the virus will acquire this kind of mutation."This is not an easy problem to fix, he said. To produce vaccines in cells means "a very expensive process for companies to just change their overall manufacturing process," Hensley explained. "You can't really do that on the drop of a dime."Meanwhile, the same seed strains used last year are being used this year to make the current vaccine, said Hensley."This year may be especially difficult because, in addition to this egg adaptive mutation which was present last year, there's indication that the H3N2 viruses are actually evolving," said Hensley.Not only will the vaccine be a mismatch with the actual circulating viruses due to egg adaptation but the vaccine could also be a mismatch due to unexpected viral evolution.What kind of flu season is ahead?It's too early to speculate which viruses will become dominant in the United States over the course of the coming flu season, said Hensley, "but it's starting to look like it will be H3 viruses." H3 viruses are influenza A viruses."There are the A group of viruses and the B groups," said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University. "The A groups are the ones that usually are responsible for large epidemics ... whereas the B flu strains usually smolder along. They always cause illness -- it can be just as severe as the A strains -- but they don't produce large outbreaks."Though last year's vaccine was mostly ineffective in thwarting the flu, it still prevented nearly 30% of hospitalizations that might have resulted, according to CDC calculations. For older adults, that rate was even higher, at 37%. Plus, the vaccine reduced outpatient visits by 42% last season.The CDC advises everyone 6 months and older to get a flu shot, as only injectable flu vaccines are recommended. More than 130 million doses of flu vaccine have been distributed so far this year and flu activity is still low across the nation.It's still early days, but experts believe we may be facing a tough season, and not only because of vaccine concerns.The reason?Australia had a tough flu season this year, with a total of 215,280 laboratory-confirmed cases and 504 flu-associated deaths reported to its National Notifiable Diseases Surveillance System as of October 13, government data show. According to a surveillance system report, adults over the age of 80 and children between 5 and 9 years old have been most affected."In general, we get in our season what the Southern Hemisphere got in the season immediately preceding us," Dr. Anthony Fauci, director of the United States' National Institute of Allergy and Infectious Diseases, said in an interview last month.An "intelligent guess," therefore, is that the Northern Hemisphere, like the Southern Hemisphere, will likely battle more cases of the viral infection, he said, though "with influenza, it is never 100%.""If H3N2 viruses dominate the US flu season again this year, vaccine effectiveness will likely be moderate to low again," said Hensley.Still, he said, everyone should get their annual flu shot."The other components of the vaccine, like H1N1 and influenza B, will likely provide excellent protection," said Hensley. "The vaccine will also likely prevent severe disease and death caused by H3N2 viruses, even though this component of the vaccine is mismatched."  6969

LA MESA, Calif. (KGTV) — The La Mesa community has continued to show its strength and resilience. But as we head into the weekend, the city's 7 p.m. curfew continues and some fear there could be more violent riots.Colorful murals now cover La Mesa businesses, destroyed by rioters and looters last weekend. For Kenny Siler, Friday is a big win. "It means the world to be able to come in here," Siler said.He drove his legally blind friends to the Vons grocery store on the first day it reopened. "If there's a good sale, [I get] a whole bunch of Gatorade, and if there's a good chunk of meat I can smoke," he laughed. He's one of the hundreds of La Mesans supporting local businesses as soon as they can. Some shop, some clean, some donate.Next to Vons, California Coast Credit Union still has not reopened. "Both ATM's and inside, everything has been just butchered," the credit union's Sr. VP of Communications, Rene McKee said.They were victims of the riots, but they are also stepping up to help. Friday, the credit union donated ,000 to the La Mesa Business Disaster Recovery Fund. The online Gofundme account continues to grow every hour, far past the original goal of ,000."It's helping to bolster the spirits of the residents here in La Mesa and these small businesses," McKee said. While glimmers of hope begin to flicker, La Mesans still face the reality that what happened last weekend, could happen again. One hundred national guard troops continue to provide added security and prevent property damage, with 100 more on standby in case the situation worsens. For Siler, who is a proud military veteran, he hopes this weekend will bring peace and order. "I support my constitution," Siler said. "Protest. But don't do what you've done," he pointed at the boarded-up walls.The money donated to the La Mesa Business Disaster Recovery Fund will be collected on June 25, 2020. Any La Mesa businesses affected by the riots can contact the East County Chamber of Commerce to apply for support funds. 2019

LA JOLLA, Calif. (KGTV) - Scientists at Stemson Therapeutics say they've found a way to create new hair cells that could become a cure for baldness."We're hoping this will be the breakthrough," says Chief Scientific Officer Alexey Terskikh.For a few years, they've been working on a two-part process that turns stem cells into hair follicles. It then implants the follicle cells into the scalp to grow new hair."We have the capability to generate brand new hair follicles," says Stemson CEO Geoff Hamilton.Using iPSC's, stem cells derived from a person's blood or existing cells, Terskikh's team can direct them to become folliculogenic cells, the building blocks of hair.They then put the cells into a microscopic scaffold-like mold made on a 3D printer. The molds are about 1/5 the size of a single strand of hair.RELATED: Here are some options if you start going baldThe scaffolds help keep the cells intact, while also telling the hair which direction to grow. That will help avoid in-grown hair or hair that grows in unnatural ways."Imagine transplanting thousands, or tens of thousands of those into a scalp," says Hamilton.Their technique is different from current hair restoration therapy because it grows new hair cells. Existing methods like Rogaine or Propecia try to revive dead cells or transplant existing cells from one area of the body to another."We're inventing as we go," says Hamilton. "We're making up the path ahead of us as we go."Eventually, they say the cost of the new cells will be similar to the cost of hair transplant surgery now, which can run upwards of ,000.In addition to being a cosmetic solution for people who have gone bald naturally, Hamilton says this could help people who have lost hair due to chemotherapy treatment or from severe burns or injuries.So far, testing has proven successful in mice. Human testing is still years away as the company works towards FDA approval.Stemson's lab is part of the Sanford Burnham Prebys Medical Discovery Institute. 2007

LAKESIDE, Calif. (KGTV) -- A driver was taken to the hospital after crashing into a palm tree and a light pole in Lakeside Monday morning. According to authorities, the crash happened along Winter Gardens Boulevard at Winter Gardens Drive around 7 a.m. Police say the driver was heading down Winter Gardens Boulevard when, for an unknown reason, he crashed into a rock and mailbox before slamming into a palm tree and a light pole. Nearby witnesses, one of whom is a nurse, rushed to help the man. He was taken to the hospital in unknown condition. Authorities say speed appears to be a factor in the crash. 616

LAS VEGAS — For the first time in 20 years, the Food and Drug Administration has approved a new drug for the treatment of the flu.  The antiviral drug, called Xofluza, is a single dose treatment.  It is for patients who are 12 or older.  The drug must be taken within 48 hours of symptoms, according to the F.D.A. "Very exciting that we have another drug on the market," said Dr. Daliah Wachs.Xofluza is said to be as effective as Tamiflu in alleviating symptoms.  "Do I think it's a lifesaver? Potentially yes," said Dr. Wachs.Unlike earlier drugs, Xofluza is expected to work against drug-resistant strains. It will also shorten the length of the flu."The longer you have the flu, the more you are at risk for complications," said Dr. Wachs.Doctors say it is still critically important for everyone to get vaccinated, especially children and the elderly.  900

来源：资阳报