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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617
SAN DIEGO (KGTV) - It looks like a mini farmer's market: fresh fruits, vegetables, herbs, even flowers.All of it coming from home gardens like Rosemary McElroy's. She and her fiancé Kevin Rookey love having fresh produce in their own backyard but, "we realized everyone has way more produce when you grow it than you can actually consume."The couple posted on the Nextdoor App, thinking maybe other neighbors wanted to trade.RELATED: Making It in San Diego: Reverse meal planning saves woman hundreds on grocery billThe response was so overwhelming, McElroy decided to organize a meet-up."This is around Lake Murray, let's host it at Lake Murray, we'll call it Lake Murray Produce just to give it a name," said McElroy.So far they've done three swaps, once a month for about an hour. Each time more and more people show up, able to walk away with organic produce for free and make sure nothing goes to waste.RELATED: Ocean Beach duo cook up 'foodie' meals on a day budget"When you have 500 oranges on a tree and you're not eating THem you feel guilt, right? So I think it’s about relieving guilt, too," said McElroy.If you'd like to know more or participate, click here. 1181

SAN DIEGO (KGTV) - Kids and teens struggling with their mental health during the Coronavirus Pandemic and weeks of protests over racial injustice have a new way to cope.BlueShield CA has expanded its Blue Sky program, increasing funding to local mental health organizations and giving kids a platform to share tips on dealing with anxiety and depression."There's a greater need now than ever," says Blue Sky Program Manager Amanda Lasik. "There's a greater need to speak to youth voices and listen and learn from what's going on."According to the CDC, 7.1% of kids age 3-17 have been diagnosed with anxiety, and 3.2% of kids in the same age group have been diagnosed with depression. Experts believe those numbers will rise because of the pandemic and protests.As part of the expansion, Blue Sky partnered with DoSomething.org to launch the "New State of Mind" campaign. Kids send tips for coping to the website, which get published through emails, texts, and social media."The response has been overwhelming," says Lasik. "When we were originally planning this campaign, we thought it'd be great if we got about 17,000 tips. We've already received over 60,000."In addition to the "New State of Mind" effort, Blue Sky has provided 0,000 to 18 youth organizations in San Diego and Alameda county. The money has helped them adapt their services to the challenges of the past few months."It's been a quick transition, but these groups are now offering counseling online, doing arts programming online, and engaging young people online in different ways," says Lasik."We've also heard from the nonprofit community that they just need a little bit of operating support."The money is in addition to the million that BlueShield pledged as part of the Blue Sky initiative last December.RELATED: South Bay schools partner with insurance company to address student mental health challengesFor high school student Joel Castro, connecting with these programs has been empowering."It gives me hope," says Castro. "It's great to see other young people get very passionate about issues and wanting to fix them." 2111
SAN DIEGO (KGTV) -- If you are experiencing mental fatigue like never before, you are not alone. Many people who are used to forging ahead in times of crisis, like this coronavirus pandemic, say the feeling is unfamiliar. Emily Chandler of Vista says she never could have imagined her kids would still be distance learning in the fall. "This has been going on so long, and I'm just exhausted," Chandler says. Her three sons are in three different schools and her oldest, Timmy, has autism. Helping them all with school means studying up on things herself. Marriage and family therapist Serene Carruthers, of Sharp Mesa Vista Hospital, says what Chandler is feeling is tied to the seemingly endless nature of the pandemic."It really is because our body is built to respond to stressful events typically that last for a duration of a short period of time," says Carruthers. "Some experts call it surge capacity. Like a battery our adaptive system can provide us with the mental, physical and emotional power to survive a short-term emergency. Then it needs to be recharged which is easier said than done during a pandemic because for many people, their self-care rituals have been upended or canceled.""It is a very lonely time and I'm not getting that energy, that recharge," says Chandler. Carruthers says not to underestimate the power of play, which is free and can be done anywhere. She also recommends shifting expectations, maintaining connections with loved ones, keeping a gratitude journal about the good in your life, and exercising even if it's just walking in your home. Chandler says the reopening of her gym helped her feel like herself again, and she and Carruthers both say it's all right to ask for help, which Chandler says she's glad she did."I got on an anti-anxiety medication and I'm not embarrassed about that. It's really, really helped me," Chandler says.What has also helped is her boys have been troopers, making it clear that sometimes the biggest challenge can also bring the greatest joy. 2031
SAN DIEGO (KGTV) -- King tides are expected to continue in San Diego on Sunday following a day of flooding in parts of the county Saturday. High tide is set to happen at 9 a.m. with low tide set to take place around 4:10 p.m., according to tide charts. King tides occur when there is an alignment of the gravitational pull of the sun and the moon. RELATED: Sandbags available in San Diego CountySome parts of Imperial Beach already experienced tidal flooding Friday morning as several homeowners reported water entered their homes.The City of San Diego built a three-foot temporary berm along parts of the bay in Mission Beach to help mitigate the risk of coastal flooding. Residents can also check the likelihood of flooding in their area, via FEMA's flood map, here.The next round of king tides are expected to roll in January 20 an 21. 847
来源:资阳报