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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

Caitlyn Jenner says she made a "mistake" in thinking she could work with President Donald Trump to benefit the LGBQT community and is now no longer a Trump supporter.In a Washington Post op-ed published Thursday, Jenner said at first she believed she could work with Trump and Republicans to change the party's stance on LGBQT issues."Sadly, I was wrong," Jenner wrote, adding, "The reality is that the trans community is being relentlessly attacked by this president."She argued that Trump "has shown no regard for an already marginalized and struggling community.""Believing that I could work with Trump and his administration to support our community was a mistake," Jenner wrote.She pointed to a New York Times report that the Department of Health and Human Services has a draft proposal to define gender under Title IX as solely male or female at birth, with no room for change.Jenner said her hope in Trump and Republicans was "misplaced" and that she "cannot support anyone who is working against our community.""I do not support Trump," she wrote. "I must learn from my mistakes and move forward."Over three years ago, the famed US Olympian came out as transgender in an interview with ABC's Diane Sawyer. Jenner voted for Trump in the 2016 presidential election and told E! in an interview Trump "would be very good for women's issues."However, Jenner began criticizing the President after the Trump administration announced a ban on transgender people serving in the military and withdrew Obama era guidance for transgender students in public schools that let them use bathrooms and facilities corresponding with their gender identity.The-CNN-Wire 1665

CARLSBAD, Calif. (KGTV) - Each Monday, a group of dedicated seniors gather in their woodshop, on a mission to make the holidays a little brighter for North County kids in need. The woodworking elves of the La Costa Glen senior living community in Carlsbad have spent nearly a year creating 100 handmade toys of all shapes and sizes.The toys have up to 39 pieces, crafted with various types of wood like walnut, cherry, and mahogany. RELATED: 10 special holiday events coming to San DiegoFive woodworkers spent the year making around 4,000 parts for the toys."It's all handmade, and a lot of love and care goes into putting it together," said Tom Woodbury, a member of the toymaking team. Countless hours have gone into the effort. Among the toys are a truck, grasshopper, and mouse. "There's a lot of detail in it, lot of small parts, lot of medium-sized parts, not too many big parts," said Woodbury.RELATED: Skate away on one of San Diego's outdoor ice rinks this holiday seasonToymaker Carolyn Rowland says she enjoys being part of the team."I feel very blessed, and I'm thankful for being able to live here. And one way to show that thanks is to give back to the community," said Rowland. This year, the toys will be donated to charities, including the Casa De Amparo in North County.The team also sells toys year-round to help cover supply costs, to learn more contact La Costa Glen in Carlsbad. 1408

BUTLER COUNTY, Ohio – A sheriff in southwestern Ohio issued a warning Wednesday to those who may wish to harm the officers in his department.Butler County Sheriff Richard K. Jones wrote in a press release that “lawlessness” directed towards law enforcement won’t be tolerated in his community north of Cincinnati.“You shoot at the police expect us to shoot back,” wrote Jones. “I will not allow my deputies or any law enforcement officer in Butler County to take the abuse I have seen over the past several months. If you come to this county expecting a free pass to harm one of my men or women in uniform keep in mind, nothing in life is free.”The sheriff cited incidents in other parts of the country over the past few months, including water being dumped on police in New York, projectiles being thrown and lasers being used to blind officers in Portland, and law enforcement being shot in U.S. cities like Chicago.The sheriff’s comments come at a time when people across the country are protesting police brutality and advocating for racial justice in their communities. While demonstrators have clashed with officers during some of these protests, it should be noted that a large majority of demonstrations have been peaceful.The sheriff’s office’s press release was posted on Facebook and has begun to go viral, racking up nearly 3,000 shares in less than a day.Jones has made other controversial statements in the past. In 2017, the sheriff made headlines when he said he had no intention of having his deputies use Narcan to help people who have overdosed. 1572

CARDIFF-BY-THE-SEA, Calif. (KGTV) - North San Diego County is hosting a celebration of Greek traditions this weekend at the 41st annual Cardiff Greek Festival. Enjoy live music, folk dancing, pastries, a fun zone, and cooking demonstrations Saturday from 10 a.m. to 10 p.m. and Sunday from 11 a.m. to 9 p.m. The event will take place at Sts. Constantine and Helen Greek Orthodox Church, 3549 Manchester Ave. Parking is free. Admission is for adults, and free for active military, police, firefighters, and children under 12. 535

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