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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - An April 30 trial date was set today for a North Carolina man accused of raping and murdering a 79-year-old woman in her Normal Heights home more than 31 years ago.Kevin Thomas Ford, now 62, was arrested in June and charged with murder and a special circumstance allegation of murder during a rape in connection with the May 20, 1987, death of Grace Hayden.Investigator Tony Johnson of the San Diego County District Attorney's Office was reviewing the cold case in May when he decided to submit a single fingerprint found on Hayden's stove to a national database.He found a match: a print submitted by police in connection with Ford's 2015 arrest on charges of communicating threats, authorities said.The fingerprint allowed San Diego detectives to issue a warrant for Ford's arrest in July.RELATED: Man pleads not guilty in 1987 rape, murder of San Diego womanThe case is expected to get pre-assigned to a judge next month. 950

SAN DIEGO (CNS) - A woman whose Nissan Versa ended up underneath a semi-truck on Interstate 8 in El Cajon Monday escaped serious injury and was arrested on suspicion of drunken driving, authorities said. Heidi Farst, 56, of El Cajon was driving westbound on I-8 near Main Street when her compact car was rear-ended by another vehicle just before 6 a.m. Farst's car then collided with the semi-truck, flipped over and landed upside down underneath the rig, California Highway Patrol Officer Travis Garrow said. Farst was freed from the wreckage and transported to Sharp Memorial Hospital for what were described as minor injuries, a CHP dispatcher said. She was then booked into the Las Colinas Detention Facility on suspicion of DUI, according to Garrow. No other injuries were reported. The crash triggered lane closures and a SigAlert. All lanes were reopened shortly after 8 a.m. 890

SAN DIEGO (CNS) - A man accosted a woman in the Fairmount Village neighborhood early Sunday and took off with her 2003 Toyota Celica, police said.He intercepted the 30-something woman in the 3800 block of 47th Street at 3:35 a.m., as she was heading to her car."The suspect pushed her to the ground and demanded her car keys," said San Diego Police Department officer Tony Martinez. "The victim complied, and the suspect fled in the victim's vehicle."Police said the vehicle's license plate is 6TQG479. The car has a rear spoiler, Martinez said.The suspect is described as a Hispanic male, about 6 feet tall with an average build. He was wearing all dark clothing with a black face mask, police said.Robbery detectives are handling the investigation.Anyone with information is encouraged to call Crime Stoppers at 888- 580-8477. 836

SAN DIEGO (CNS) -- Hundreds of thousands of San Diegans are expected to cast their ballots in person today, Election Day, with over 1 million ballots already received.The San Diego County Registrar of Voters said more than 1.1 million ballots have been received and nearly 60,000 residents have voted early in-person as of Monday, well more than double when compared to this point in the 2016 presidential election.Of the 1.95 million registered voters in the county, 1,114,627 had already turned in their ballots as of election eve. Over the weekend, 44,370 residents cast early votes at the county's polling locations and another 10,391 have voted early at the registrar's office since Oct. 5.ELECTION 2020: Latest Results, Key Races & Ballot MeasuresMail-in ballots were sent to all registered voters in the county on Oct. 5, even those who had not requested one.Voters who prefer to cast their ballots at their assigned polling place on Election Day can do so between 7 a.m. and 8 p.m. Tuesday.An in-person voting location tool can be found on the county's voting website, SDvote.com.The day before the 2016 election, San Diego County had recorded 507,127 mail ballot returns. More than a million people voted that year for a voter turnout of 81%.Registrar Michael Vu anticipates turnout of anywhere between 80 and 85%, or 1,559,260 to 1,656,710 voters, in San Diego County this time around.That could mean anywhere from 389,870 to 487,320 residents could cast ballots in person Tuesday -- depending on how many cast ballots by the end of the day Monday -- at one of the county's 235 "Super Poll" locations.In the 2012 election, 77% of eligible voters cast a ballot. In the 2018 and 2014 Gubernatorial Elections, just 66% and 45% -- respectively -- of the electorate voted.During the March primary, about 1,600 polling locations were open to the public. The COVID-19 pandemic caused that number to shrink considerably. Even so, more than 4,000 poll workers will manage locations such as SDSU's Viejas Arena, the San Diego Convention Center, Rincon and Sycuan tribal halls and the Walnut Grove Park Red Barn in an Marcos. The 235 polling locations represent 572 polling precincts.Due to the COVID-19 pandemic, the registrar's office encourages older adults and people with underlying medical conditions to avoid long lines and crowded polling places by voting early.Vu said his office is working with county public health services to ensure the health and safety of election workers and voters. Personal protective equipment and sanitation supplies will be provided to staffers so they can conduct the election process safely.Voters casting ballots in person are instructed to bring a face mask and plan to maintain social distance.Locations of vote centers were chosen and configured to allow for queuing and voting while maintaining six feet of social distance. Masks will be required inside, but residents unable or unwilling to wear them will be allowed to vote curbside.Officials noted that the need to social distance may create longer lines than usual at in-person locations. 3093

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