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WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.
SAN FRANCISCO, April 28 (Xinhua) -- Microsoft Corp. on Thursday posted quarterly revenue and earnings that both beat analysts' expectations.In its fiscal 2011 third quarter ended on March 31, the software giant reported revenue of 16.43 billion U.S. dollars, up 13 percent from the same period a year earlier.Net income and earnings per share were 5.23 billion dollars and 61 cents, representing increases of 31 percent and 36 percent respectively year-on-year.Analysts had expected earnings of 56 cents per share on revenue of 16.19 billion dollars, according to Thomson Reuters."We delivered strong financial results despite a mixed PC environment, which demonstrates the strength and breadth of our businesses," Peter Klein, chief financial officer at Microsoft, said in a statement."Consumers are purchasing Office 2010, Xbox and Kinect at tremendous rates, and businesses of all sizes are purchasing Microsoft platforms and applications," he added.Revenue at four of Microsoft's five major divisions posted double-digit growth in the quarter, indicating the increase of technology spending by enterprises as well as strong demand for the company's entertainment products.The entertainment and devices division saw the biggest revenue growth of 60 percent, which according to Microsoft, were driven by strong demand for its Kinect hands-free motion control system for Xbox 360 and continued strong sales of Xbox 360 console.However, revenue for the division of the company's flagship Windows operating system dropped 4 percent in the quarter, which Microsoft said was "in line with the PC trends."The performance of the Windows division may fuel new concerns that Microsoft's dominance in software for PCs is being threatened by Apple's iPad and tablet computers running other operating systems, some analysts noted.

You can think of NASA's Discovery program as a sort of outer-space American Idol: every few years the agency invites scientists to propose unmanned planetary missions. The projects have to address some sort of fundamental science question, and (this is the tough part) they have to be relatively cheap to pull off — say, half a billion dollars or so. Then the proposals go through a grueling competition before judges who aren't as nasty as Simon Cowell but who are every bit as tough. The one left standing at the end gets the equivalent of a recording contract: NASA supplies the funding and the launch vehicle, and away the winner goes — to orbit Mercury, as the Messenger spacecraft is doing right now; or to rendezvous with a couple of asteroids, as the Dawn mission will start doing this July; or to smash into a comet on purpose, a feat achieved by Deep Impact in 2005, a mission not to be confused with the movie of the same name. Now it's time for the next contenders. NASA has just announced that the first round of the latest Discovery competition is over, with three entries out of 28 moving on to the finals. They are, in increasing distance from Earth: the Geophysical Monitoring Station (GEMS) lander, which would use seismometers to study the interior of Mars; the Comet Hopper, which would do just that, leaping from place to place across the surface of Comet 46P/Wirtanen to see how different parts of the tumbling body react to heating by the sun; and the Titan Mare Explorer (TiME), which would plop into a sea of liquid hydrocarbons on Saturn's moon Titan — the first oceangoing vessel ever to set sail on another world. If you had to come up with a theme that ties all three missions together, it would be "origins." The Titan explorer, for example, will be studying a place that — in a crude way, at least — resembles the early planet Earth at a time when life arose here. Titan, with a thick atmosphere and a bizarro-world form of weather featuring toxic winds and hydrocarbon rain, is home to a mix of complex chemistry, complete with organic molecules. The oceans provide a medium in which the molecules can move around and interact with each other. It's even conceivable, though clearly a long shot, that some form of microscopic life already exists on this frigid moon. The Mars lander, by contrast, would visit a place where the seas — plain water in this case — vanished long ago. But the mission of GEMS goes far deeper than that. By analyzing Marsquakes on the Red Planet, GEMS will try to get a handle on what the interior of Mars is like. Scientists don't currently know whether the planet's core is liquid, like Earth's, or solid, or some mushy consistency in between. It all depends on how efficiently Mars has cooled since it formed 4.5 billion years ago, and that depends in turn on the planet's internal structure. "That's the mission," says Bruce Banerdt, of NASA's Jet Propulsion Laboratory, the lead scientist for GEMS. "We want to understand how Mars was built." Along with sensitive seismographic equipment, GEMS will drill down about 20 ft. (6 m) with a thermometer-equipped probe, trying to figure out how quickly the temperature rises with depth. "That will let us extrapolate all the way down to the center," Banerdt says, "which will tell us how fast Mars is cooling."
BEIJING, March 19 (Xinhua) -- In spite of the fact that snow still covers his farmland, Jiang Chen has been busy stocking fertilizers and seeds to prepare for the coming spring farming season."I am almost ready for the sowing," said Jiang, a 64-year-old peasant who farms five hectares of cropland in Liujia Township in Yushu City, northeast China's Jilin Province. "But the costs are rising so I still want to look for better seeds providing a higher yield this year."As the Chinese government continued policies to assure a good grain harvest this year, millions of farmers like Jiang in China's major grain-producing regions such as Jilin, Heilongjiang, Shandong and Henan provinces are now gearing up to finalize preparations for the coming sowing season.The central government's incentives in 2011 include increases in minimum rice purchase prices by 9.7 percent to 21.9 percent from last year, as well as 24.9 billion yuan (about 3.77 billion U.S. dollars) in subsidies to the national grain risk fund for farmers."Though farmers are richer now than before, our economic strength remains relatively weak as compared with urban residents," Jiang said.He noted that he was considering investing less this year because the cost of agricultural production has increased year after year.The average urea price from manufacturers and retailers rose about 10 percent from last year to about 1,980 yuan and 2,100 yuan per tonne at a grain and oil wholesale market near Yuquan Road in Beijing, where many farmers from neighboring Hebei, Henan and Shandong provinces buy agricultural fertilizers and additives.Urea is the primary fertilizer used by Chinese grain growers, though many of the farmers said that they would reduce the use the compound in their fields due to rising prices and the impact on wheat caused by the widespread drought in north China this winter.Wang Quan, the president of China National Agricultural Means of Production Group Corp., the country's largest supplier of agricultural materials, predicted that the use of urea during the spring farming season would be between 20 million tonnes to 25 million tonnes, which is about two fifths of the year's total.Wang said that the urea price is around 400 U.S. dollars per tonne in global markets, or 15.7 percent higher than the domestic price."I think it takes time for Chinese farmers to accept the price hikes gradually," he added.Analysts say that the different perceptions on urea prices between manufacturers and farmers may have affected China's crops because the reduced use of fertilizers usually mean less grain output in the country since many farmers depend more on fertilizers, rather than technology to boost production.China's grain output rose 2.9 percent last year to 546.41 million tonnes, marking the seventh consecutive year of growth. The country aims to keep its 2011 grain production over 500 million tonnes, according to an executive meeting of the State Council, or the Cabinet, Thursday.Chinese Premier Wen Jiabao said last month that rising costs of grain production, the lingering drought in north China's major wheat-growing regions and the weakening of agricultural production in some areas would directly affect China's summer grain output.Facing challenges such as higher costs for growing grain, Jiang believed that he could generate higher income from his crops this year with the support of the agricultural sector by the government."If the grain prices also rise this year, I can still earn a net income of 10,000 yuan for every hectare of farmland," Jiang said."I hope to keep my farmland from being seized for industrial or residential development," he added.
LOS ANGELES, April 12 (Xinhua) -- With the help of NASA Telescopes, astronomers have uncovered one of the youngest galaxies in the distant universe, with stars that formed 13.5 billion years ago, the Jet Propulsion Laboratory (JPL) announced on Tuesday.The finding addresses questions about when the first galaxies arose, and how the early universe evolved, JPL noted in a press release.Infrared data from both the Hubble Space Telescope and the post- coolant, or "warm," phase of NASA's Spitzer Space Telescope mission revealed that the galaxy's stars are quite mature, which means they must have formed when the universe was just a toddler, said JPL in Pasadena, Los Angeles.This challenges theories of how soon galaxies formed in the first years of the universe and could even help solve the mystery of how the hydrogen fog that filled the early universe was cleared, according to astronomers involved in the study.This galaxy is not the most distant ever observed, but it is one of the youngest to be observed with such clarity, JPL said.Normally, galaxies like this one are extremely faint and difficult to study, but, in this case, nature has provided the astronomers with a cosmic magnifying glass, JPL said.The galaxy's image is being magnified by the gravity of a massive cluster of galaxies parked in front of it, making it appear 11 times brighter. This phenomenon is called gravitational lensing."Without this big lens in space, we could not study galaxies this faint with currently available observing facilities," said Eiichi Egami of the University of Arizona in Tucson. "Thanks to nature, we have this great opportunity to see our universe as it was eons ago."The findings may help explain how the early universe became " reionized," according to JPL."Seeing a galaxy as it appeared near the beginning of the universe is an awe-inspiring feat enabled by innovative technology and the fortuitous effect of gravitational lensing," Jon Morse, NASA's Astrophysics Division director at the agency's headquarters in Washington, said in the release."Observations like this open a window across space and time, but more importantly, they inspire future work to one day peer at the stars that lit up the universe following the big bang."
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