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Maryland-based vaccine developer, Novavax, has received .6 billion from the federal government to complete late-stage clinical development; set up large-scale manufacturing; and deliver 100 million doses of NVX?CoV2373, its COVID-19 vaccine candidate, as early as late 2020.This is the largest vaccine deal to date with the Trump administration as part of their Operation Warp Speed, which is focused on making a COVID-19 vaccine and treatments available as quickly as possible.Novavax has not brought any of their developed vaccines to market. According to information on their website, they have developed several vaccines for infectious diseases, however they are all in various stages of development or clinical trials. These include vaccines for the seasonal flu and RSV. Other vaccines created by Novavax are not actively being developed or studied at this time, including ones for Ebola, MERS, and SARS.According to a statement from Novavax, the agreement with the federal government includes the company demonstrating being able to rapidly get manufacturing and large-scale production of the vaccine going once approved. Novavax hopes to conduct their late-stage clinical study with 30,000 subjects in fall 2020.An early-stage clinical study took place in Australia in May on 130 participants. Study results are expected at the end of July.“Today’s .6 billion investment supports the Novavax candidate, depending on success in clinical trials, all the way through to manufacturing 100 million doses for the American people,” said U.S. Health and Human Services Secretary Alex Azar.Regeneron Pharmaceuticals has also received 0 million through Operation Warp Speed on Tuesday, to make and supply its COVID-19 vaccine candidate, REGN-COV2. Their vaccine is currently in phase 2 and phase 3 clinical studies for the treatment and prevention of COVID-19.Regeneron has several vaccines on the market currently, including Dupixent, used to treat allergic diseases such as eczema, asthma and nasal polyps which result in chronic sinusitis, and Praluent, used to treat high cholesterol. 2101

MILLIKEN, Colo. — Beatriz Rangel holds onto precious moments with her father. She took hundreds of pictures over the years, and now, she is more grateful than ever to have them.Her family made time to visit each other every single week, but they also loved vacationing together. “We’d just hit the road and go everywhere,” said Rangel of her parents and siblings.Looking back on their moments of joy is now helping Rangel find a shred of peace.“He loved posing for pictures and I loved taking them,” she said of her dad, Saul Sanchez. “We had so many good times.”She never expected those memories to end so soon. “I still have a hard time believing that my father is gone.”At 78 years old, Sanchez died on April 7 after a weeks-long battle with COVID-19. The loss is still fresh in Rangel’s mind.“I got a text, a group text message, from my older sister that said, ‘Dad and mom were just here. Dad can't even walk. There's something definitely wrong,’” said Rangel.Soon after, Sanchez went to the hospital and he tested positive for the virus. That was the last time his family would see him in person.Rangel made sure to speak to her dad as much as she could while he was in the hospital. “I called him and he sounded great,” she said. “He’s like, ‘Hi honey, hola mija. You know I'm doing OK. I’ll be fine, I’ll be back to work on Monday,’” Rangel remembered.However, Sanchez never left his hospital bed. Within days, doctors put the father of six on a ventilator.“We just thought, ‘Oh they're going to help him breathe,’” said Rangel.Sanchez’s condition took a turn for the worse suddenly and Rangel got a call she will never forget.“They're like, ‘We want you to say goodbye, and they're taking him off the ventilator.’ I just told him that…that I loved him, and I was going to miss him, and thank you for all the lessons, but I knew he wanted us to be happy. You know, he wanted us to find joy in whatever we did, 'cause he loved life. They took him off the ventilator, and within like two, three minutes he passed away, so it was very, very hard,” said Rangel through tears.Months later, with the pain of the loss still just as deep as it was in the spring, the true cost of this virus is becoming all too clear to Rangel and her family.“He helped so many people, and he was, for our family, the glue. So I think we all really, really miss that. We miss that one person that always made us feel like anything was possible.”Saul Sanchez’s life proved just that. He brought his family from Mexico to America, leaving his life behind for a better future for his children.“He came here with nothing because of my sister Patty being sick and needing health care, and his biggest thing was education. He went and got his GED at 60, 60 years old. He didn't care about his age, he cared about what he could learn and how he could be a help to society and contribute to the community,” said Rangel.Losing the person who cared about her family most is making a time of year meant for joy harder than she imagined, and now Rangel just hopes her community will see the hole in her heart as a warning to keep others safe.“I feel like he was my backbone, and I don’t have it anymore,” said Rangel. “You go through, ‘Who am I?’ You’re lost, because I don’t have him to tell me, ‘Honey you’re going to be fine, you’re going to be great.’”For the more than 250,000 Americans who have passed away from COVID-19 this year, their families know the same pain. Counselors say making time for the traditions your loved one enjoyed can help honor their memory. That’s something Rangel plans to do.“It’s very hard to have the spirit to want to celebrate,” she said. “It is going through the motions, but we still have to do it because that's what Dad would want.”Even though this Christmas cannot bring her the gift she really wants, Rangel knows the warmth and kindness her dad showed her will be there.“There is a lot of goodness that went away with him, but I was thankful, grateful to have him fifty two years of my life,” she said. 4024

Midterms, look what you made Taylor Swift do.In a rare move, singer Taylor Swift has weighed in on politics in a major way, endorsing Tennessee Democrats Phil Bredesen and Jim Cooper, who are running for Senate and House of Representatives, respectively.By her own admission, Swift has been "reluctant" to voice her political opinions in the past, but, she said in an Instagram post, "due to several events in my life and in the world in the past two years, I feel very differently about that now.""I always have and always will cast my vote based on which candidate will protect and fight for the human rights I believe we all deserve in this country," she wrote. "I believe in the fight for LGBTQ rights, and that any form of discrimination based on sexual orientation or gender is WRONG. I believe that the systemic racism we still see in this country towards people of color is terrifying, sickening and prevalent."Swift went after Bredesen's senate race rival, Republican Rep. Marsha Blackburn, in her post, saying the politician's voting record "appalls and terrifies me."Bredesen served as governor of Tennessee from 2003 to 2011.In a tweet, Bredesen thanked Swift for her "kind words.""I'm honored to have your support and that of so many Tennesseans who are ready to put aside the partisan shouting and get things done," he wrote. "We're ready for it.""The choice continues to be clear: voters can either have more of the same old partisan shouting that's coming out of D.C, or they can hire someone who has a track record of getting things done for Tennessee," Bredesen's campaign added in a statement to CNN.Swift included a plea to her young adult fans in her post, urging them to register before the deadline."So many intelligent, thoughtful, self-possessed people have turned 18 in the past two years and now have the right and privilege to make their vote count," she wrote. 1907

Many Thanksgiving traditions will likely change this year for many Americans, as health officials warn people against having large gatherings.Food and grocery experts preparing for the holiday are also noticing some new trends when it comes to that traditional Thanksgiving meal."We are definitely seeing turkeys selling in smaller portions, so people aren’t buying whole birds. We anticipate Americans are going to be buying smaller parts like wings, legs, cutlets. We definitely saw that going up in Canada, so we expect the same here," said Instacart trends expert Laurentia Romaniuk.Romaniuk says they first looked at buying trends for the Canadian Thanksgiving, which occurs in October. They found people aren't just buying smaller turkeys, but also choosing to make healthier sides."We're seeing customers go after a lot of healthier alternatives. This includes things like chickpea-based pasta, instead of regular pasta. So, a classic Thanksgiving dinner might include mac and cheese, and this year, we’re seeing Banza, which is a brand that makes chickpea-based pasta, go up by 333 percent, and actually, we’re ready starting to see that take off," said Romaniuk.And some people may not even want to cook their Thanksgiving meal at all, especially if they're having a smaller celebration than normal.Milton's Cuisine and Cocktails in Georgia is prepping more than 400 turkeys this year for their gourmet Thanksgiving dinner with all the fixings to go."We do an apple brined and smoked turkey; they are 12 to 14 pounds. We say it feeds six to eight people. It comes with sage-corn sweet bread which is our version of dressing and then a Madeira turkey gravy," explained Derek Dollar, Milton's executive chef and managing partner.This year, Dollar says, getting a Thanksgiving meal to-go is a good way to support a restaurant this year. He believes more restaurants will continue to close their doors for good because of the pandemic, and any support is appreciated."People are definitely jumping on board. Luckily, we were ahead of the curve and we’ve already done it," said Dollar.However you decide to eat your Thanksgiving meal this year, Dollar advises to not wait until the week of Thanksgiving to make your decision."We pre-ordered just to get it allocated, and big corporations aren’t ordering extra like they normally do. My people are telling me that there’s larger birds left, which is what you’re saying is not the trend, and I think if people wait too long like the week of Thanksgiving, they might not be able to get one at the grocery store or anywhere else, unfortunately," said Dollar. 2616

MALIBU (CNS) - Santa Ana winds were expected to continue to plague firefighters battling the deadly Woolsey Fire in Los Angeles and Ventura counties Tuesday as officials re-emphasized to evacuated residents that they must stay away until the area has been declared safe.Winds of 25 to 35 mph were forecast to blow with gusts of 40 to 45 mph, National Weather Service Meteorologist Joe Sirard said. Those wind speeds are likely to drop to 25 to 30 mph Tuesday night into Wednesday with gusts to 40 mph.That prompted the NWS to continue its Red Flag Warning through 5 p.m. Wednesday for the Woolsey Fire area in Los Angeles and Ventura counties -- except Malibu, where the Red Flag Warning is set to expire at 5 p.m Tuesday. High temperatures of 70s to low 80s are predicted through Wednesday with lows near freezing ``in wind-sheltered areas,'' Sirard said.The latest Woolsey Fire update from Cal Fire had at least 435 structures destroyed, 24 structures damaged and the estimated number of structures still threatened about 57,000.The blaze has burned about 93,700 acres and was 30 percent contained, with full containment not expected until Thursday, Cal Fire said. The two people who died were found inside a burned vehicle in a long driveway in the 33000 block of Mulholland Highway.``It's the feeling of homicide detectives that the driver became disoriented and the vehicle was overwhelmed by the fire,'' sheriff's Chief John Benedict said.Three firefighters have been injured battling the Woolsey Fire. And Malibu City Councilman and Mayor Pro Tem Jefferson ``Zuma Jay'' Wagner was recuperating at a hospital from conditions related to his unsuccessful efforts to save his home Friday night.Firefighters were focused on making sure any hot spots in Malibu Canyon don't cross into Topanga Canyon, because a falling ember has more than a 90 percent chance of igniting brush, authorities said.Some 3,592 firefighters were assigned to battle the blaze, while, 22 helicopters worked from above, officials said. A total of 619 engines, 48 water tenders, 23 bulldozers and 57 hand crews were sent into the battle, Cal Fire reported. Crews from other areas, including Orange County and Arizona, also sent firefighters and equipment to aid the battle.The continuing danger prompted Los Angeles County officials to re-issue a warning to residents in evacuated areas to stay away until conditions are deemed safe.``Although it may appear that fire threats have passed in some communities, officials warned that the situation remains unstable and can shift dangerously with changes in wind patterns and other unpredictable factors,'' the advisory noted. Officials noted there are downed power poles and live power lines, live embers that could reignite, buckled roads, landslides and unstable ground, massive debris, unhealthy air quality, poor visibility and now power or cell phone access.While some evacuation orders for county communities remained in effect, all mandatory evacuation orders for the City of Los Angeles were lifted as of 7:47 p.m. Monday, authorities said.The Los Angeles County Sheriff's Department also announced that people were returning to their homes in Agoura Hills, Westlake Village, Oak Park, North Ranch and Newbury Park residents affected by the fire. Cal Fire announced Monday evening that evacuation orders have now been lifted for West Hills in Los Angeles and Bell Canyon in Ventura County.But the entire city of Calabasas remained under mandatory evacuation orders Tuesday.Despite messages to the contrary on social media, officials are not escorting residents back into the evacuated areas to retrieve medications, Los Angeles Police Lt. Eric Bixler said.Malibu City Councilman Skylar Peak has asked people to refrain from attempting to get back into Malibu by boat. A community meeting for Malibu-area evacuees was scheduled for Tuesday night at Santa Monica High School's Barnum Hall.The sheriff's department has repeatedly tried to reassure residents that their homes would be safe from looters, with 500 to 600 deputies on 12-hour rotational shifts.Northbound and southbound Ventura (101) Freeway from Valley Circle Boulevard remained open. Pacific Coast Highway remained closed to all traffic from the Ventura/Los Angeles County line to Sunset Boulevard.The fire has also closed libraries in Agoura Hills, Malibu, Topanga and Westlake Village. There's no word yet on when the libraries would reopen.The California Public Utilities Commission was investigating Southern California Edison for its possible role in the fire.According to CPUC, electrical infrastructure may have suffered malfunctions near ground zero of the blazes two minutes before they began.The agency also is investigating PG&E for its possible role in the Camp Fire in Butte County, which has burned 113,000 acres and resulted in at least 42 deaths.Chris Thompson of SCE said there were 13,000 customers who initially lost power, mostly in Malibu, and now that number has been reduced to 9,000.He also said that it will take time to replace the telephone poles destroyed by the fire, especially in canyon areas. He said they will need to use a helicopter to bring in the new poles. ``We can't just drive poles in on a truck to those areas,'' he said.The fire -- which began Thursday afternoon -- has forced the evacuation of at least 75,000 homes and an estimated 265,000 people in L.A. and Ventura counties as it consumed multimillion-dollar mansions and mobile homes.In Malibu, Pepperdine University said the school's Malibu and Calabasas campuses would remain closed through Thanksgiving. All Malibu schools in the Santa Monica Malibu Unified School District will remain closed until at least Thursday, the district announced. City officials said there will likelybe intermittent power outages due to weather and fire conditions.Fire information for Los Angeles County can be found at www.lacounty.gov/woolseyfire. Malibu also has established a website to update fire information at www.malibucity.org/woolsey.The Conejo Unified School District, which includes parts of Los Angeles and Ventura counties, closed its schools for Tuesday after inspectors found that at least two schools required major clean-up.The Federal Aviation Administration sent a tweet reminding drone operators that they could face severe civil penalties and potential criminal prosecution for flying drones over fire areas.Officials with the Santa Monica Mountains National Recreation Area are trying to account for the 13 mountain lions they are tracking with GPS collars. They said eight of the cougars are alive and moving but they have received no transmissions since the fire began from five of them. They also have been unable to locate four bobcats. The park is closed due to wildfire danger.In an about face from Twitter attacks last week against California's forest management, President Donald Trump has tweeted that he has approved an ``expedited request'' for a major disaster declaration for California.``Wanted to respond quickly in order to alleviate some of the incredible suffering going on. I am with you all the way. God bless all of the victims and families affected,'' Trump said.Firefighters made progress on the much smaller Hill Fire north of Malibu and south of Simi Valley in Ventura County. That wildfire, which has consumed about 4,500 acres and destroyed two structures, was 80 percent contained. No civilians or firefighters were killed or injured and fullcontainment was expected Wednesday. 7519