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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

VIENNA, Nov. 25 (Xinhua) -- China is to further help the least developed countries (LDCs) in their development effort through zero-tariff treatment and other measures, Yu Jianhua, China's Assistant Commerce Minister said here Friday.Addressing a LDCs Ministerial Meeting in Vienna, Yu said China will focus on six concrete measures to advance the implementation of the Programme of Action (IPoA), adopted by the Fourth United Nations Conference on LDCs in Istanbul in May.First, as announced by Chinese president Hu Jintao during the G20 summit in Cannes, China would, in the context of South-South cooperation, give zero-tariff treatment to 97 percent of the tariff items of exports to China from the LDCs that have diplomatic relations with China.Second, tilt foreign aid further to the LDCs.Third, carry out cooperation in livelihood projects in the LDCs, including hospital, school, domestic water use and clear energy.Fourth, strengthen agricultural cooperation with the LDCs, including the increase of food aid, dispatching agricultural and technical experts.Fifth, strengthen personnel education in the LDCs to build capacity for self-development.Sixth, continuously promote the establishment of economic and trade cooperation zone in the LDCs by Chinese companies.Yu said that debt crisis in some countries, turmoil in financial markets, inflation pressure in emerging countries; extreme weather and recurrent natural disasters have brought enormous harm to the economies of the LDCs.In this situation, the global community should stand united to give more supports to the LDCs, he stressed.For a long time, China has actively supported the LDCs, under the framework of the South-South Cooperation, through economic and technical aids, debt reduction and personnel training and increase of imports from these countries, he said.Meanwhile, Yu praised the unique role of the UN Industrial Development Organization (UNIDO) in implementing the IPoA, helping structural transformation in the LDCs and promoting the sustainable development.He also said that the Chinese government would continue to support the UNIDO and help the LDCs develop their economies in an all-round way.

COPENHAGEN, Oct. 1 (Xinhua) -- Denmark implemented a tax on foods high in saturated fat from Saturday, the first of its kind in the world, which will affect products containing more than 2.3 percent saturated fat.Butter, cream, cheese, meat, cooking oil and processed foods like pizza and dark chocolate are among thousands of products affected. The so-called fat tax is pegged at 16 Danish kroner (2.87 U.S. dollars) per kilo of saturated fat.Thus, a 250-gram packet of butter, which previously cost 15.5 Danish kroner (2.78 dollars), will now cost 18.10 Danish kroner (3.25 dollars). And the cost of a liter of olive oil has risen from 38.95 Danish kroner (7 dollars) to 41.60 Danish kroner (7.48 dollars), for example.Some Danes began hoarding the affected products ahead of Saturday's deadline, while stores across Denmark rushed to mark-up prices of these goods.Although the new tax will mean higher costs for consumers and many food product manufacturers, the Danish government believes the tax is a good way of reducing Danes'consumption of fatty foods.Local producers are worried the tax will give an unfair advantage to manufacturers from neighboring countries who, they say, can now sell their products more cheaply in the Danish market.However, tax authorities here said imported food products will also be subject to the tax.

SAN FRANCISCO, Dec. 2 (Xinhua) -- About one in 10 mobile phone subscribers in the United States is now using an Apple iPhone, said a new survey released on Friday.Latest survey results from research firm comScore showed that for the three-month period ending in October, Apple remained the No. 4 handset maker in the U.S. with its share of mobile subscribers rising to 10.8 percent from 9.5 percent in the previous three months.Among the top five mobile phone brands in the U.S. market, Apple is the only one that saw its market share increase in the quarter, according to the survey.Samsung was still the top handset manufacturer with 25.5 percent of U.S. mobile subscribers, followed by LG and Motorola taking the second and third place with 20.6 percent and 13.6 percent of share respectively.Research in Motion (RIM), maker of Blackberry, ranked No. 5 with a share of 6.6 percent.Except Apple, market shares of the other four brands remained unchanged or dropped from the previous quarter.Apple's gain in the quarter might be driven by the introduction of new model iPhone 4S which went on sale on Oct. 14, and the addition of Sprint as a carrier in the U.S. market, some analysts said.The survey by comScore, which involved more than 30,000 U.S. mobile subscribers, found that 234 million Americans age 13 and older used mobile devices by the end of October.

BEIJING, Sept. 30 (Xinhuanet) -- China's space dream took a step closer to reality as the Tiangong-1 module blasted off into the night sky on Thursday from the Gobi Desert.The Long March II-F T1 rocket, under the unmanned module, Tiangong-1, lifted off from the Jiuquan Satellite Launch Center at 9:16 pm as planned.Ten minutes later Tiangong-1 separated from the rocket on its way to orbit, 350 kilometers above Earth. The module deployed its two solar panels, which provide power, at 9:28 pm.At 9:39 pm, Chang Wanquan, chief commander of the manned space program, declared the launch a success as cheers and applause echoed around the command and control center in Beijing.President Hu Jintao and other members of the Standing Committee of the Political Bureau of the Communist Party of China Central Committee went to the center to witness the launch.Premier Wen Jiabao watched at the Jiuquan Satellite Launch Center as the Long March rocket, carrying the space lab, blazed into the night sky.The launch paves the way for China's first rendezvous and docking mission. An unmanned Shenzhou VIII spaceship will be launched in November to dock with Tiangong-1.Two more missions are scheduled for next year and astronauts will board Tiangong-1, which can also function as a space lab.If the mission succeeds, China will become the third country to master spacecraft rendezvous and docking technology following the then Soviet Union and the United States, experts said.Wu Ping, the space program's spokeswoman, said that the ability to rendezvous and dock is vital for building a space station, which China has scheduled for around 2020."A space station cannot be launched in one shot. The modules must be launched separately and then assembled in space," she said.China has invested 35 billion yuan (.47 billion) in total on its manned space program since 1992, when it was approved, she told China Daily.The first phase, from 1992 to 2005, accounted for 20 billion yuan. During this period, China launched six Shenzhou spaceships to set up a system transporting astronauts between Earth and space.In the second phase, from 2005, 15 billion yuan has been spent on projects, including Shenzhou VII and the first rendezvous and docking mission, she explained.Zhou Jianping, chief designer of China's manned space program, said that the space lab and future space station provide a rare platform for conducting experiments that could lead to breakthroughs in the study of materials and biological pharmacy."Experiments made in the microgravity of space can lead to unexpected results," he said.For example, gas and liquid are unable to mix on Earth, but in space they mix naturally, he said."The primary purpose of China's manned space station is to peacefully explore space, and through it, serve mankind," he said.Some have questioned the participation of the military in the program. However, the military has experience in coordinating large-scale requirements that are vital for the program and their involvement reflects international norms, Ministry of National Defense spokesman Geng Yansheng said on Wednesday.He reiterated that China is firmly opposed to the weaponization of space and the program is peaceful.China is now in the second phase of its manned space program. The goal of the program, which has three steps, is to build a 60-ton space station around 2020.The second phase focuses on mastering four key technologies for assembling a space station.The first of these, extravehicular activity, was completed successfully in 2008 after Shenzhou VII was launched.Rendezvous and docking is what is being experimented with. The third technology involves cargo spaceships ferrying supplies to a space lab. The fourth tackles problems concerning the prolonged sustaining of life on a space lab, especially recycling air and water.Besides the manned space program, China launched two lunar orbiters in 2007 and 2010. It plans an unmanned lunar landing around 2013, and returning moon samples in 2017.

来源：资阳报