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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735

CORONADO, Calif. (KGTV) — Coronado is getting a touch of Hollywood Saturday, as 200 stars are installed in honor of cinema's leading icons.As the city ramps up for the Coronado Island Film Festival Nov. 8-11, volunteers will place stars featuring the names of Hollywood actors and filmmakers along Orange Avenue to construct its own Coronado Walk of Fame.Coronado's cinematic history dates back more than 100 years. One of the most well-known films to showcase the island is "Some Like it Hot," which featured the Hotel Del Coronado. The hotel was also featured in other flicks like "My Blue Heaven," "K-9," and "The Stunt Man."Of course, Naval Air Station has hosted Hollywood stars as well. Most recently, actor Tom Cruise was seen on base during filming of the next "Top Gun" film, "Top Gun: Maverick."Coronado's Walk of Fame will highlight names including Marilyn Monroe, Jack Lemmon, Desi Arnaz, Kevin Bacon, Judd Apatow, Charlie Chaplin, Bette Davis, Judy Garland, and many more.CIFF tickets are available online. The four-day festival will celebrate the island's film history with more than 90 film screenings, panels, workshops, and parties. 1158

CLEVELAND — Police in the Cleveland area now report a total of five Amazon delivery trucks have been stolen in northeast Ohio since Nov. 25, and with them, hundreds of packages. Investigators say in some cases the vehicles are taken by thieves as the Amazon driver leaves the running truck to make a delivery.Cleveland Heights Police Chief Annette Mecklenburg said that's exactly what happened on Dec. 13, after thieves stole an Amazon vehicle during a delivery."The driver was delivering a package, she had exited the truck and was putting it on the porch," Mecklenburg said. “A truck pulled up and one of the men got out and jumped in the Amazon truck and drove away. The truck had been left running with the keys in it. It is possible up to 200 packages, we believe, were in the truck at the time it was stolen. To me it’s just heartbreaking for all the people who had ordered. You know people were ordering online to be safe because they didn’t want to get sick, so many more people were ordering on-line and were looking forward to these packages and these gifts. It’s so close to Christmas, it really is sad, I feel horrible for the people who may not get these packages in time for the holidays.”Mecklenburg said the Amazon driver was not hurt, and said GPS tracking on-board the delivery truck helped speed-up the recovery effort.“Unfortunately, there were no cameras on the truck, and at this time we couldn’t find any cameras in the immediate area where the truck was stolen,” Mecklenburg said. “It’s my understanding that it’s their policy to leave them running when they exit it to deliver a package. We have heard that with some of these trucks, drivers are being robbed by people with guns.”News 5 contacted Amazon headquarters about the truck heists, and asked if these cases have the company considering delivery protocol changes, or adding truck surveillance cameras to assist police make arrests. The company responded quickly, and said the issues are extremely important to their organization, and once they speak with police the company will issue a statement.Meanwhile, Mecklenburg said the crooks will face felony theft charges when found.“Because we’re not going to give up, our detectives are not going to give up, our officers are not going to give up," Mecklenburg said. “I got to believe that there is someone out there who knows who did this, I mean we’re talking 200 packages, and they ended up somewhere.”This story originally reported by Joe Pagonakis on News5Cleveland.com. 2515

COVID-19 is changing the way we do a lot of things, and one of those things include how you get treatment from a doctor.Craig Nuttall, a nursing professor at Brigham Young University in Provo, says he also works in an emergency room when he's not teaching, and he has found that using a regular stethoscope is almost impossible when he's equipped with personal protective equipment."I’ve been working with Dr. Teng on this digital stethoscope for another project in India and I thought this is the perfect application for this," said Nuttall.Using an existing open-source 3D printed design, Nuttall worked with Chia-Chi Teng, an information technology professor at BYU, to create a digital stethoscope.It works with an app to live stream or record a patient's heartbeat up to a range of 50 feet to a pair of Bluetooth headphones or a speaker.The patient would hold it up to points on their chest under the direction of a doctor or nurse.Teng says another great thing about this is it's easy to put together with just a few parts.He helped develop the 3D printed parts to form a functional, digital stethoscope that costs less than to make.Both professors admit that while digital stethoscopes have been around for some time, they are still expensive, so this is a low-cost way to make them for doctors across the country and even around the world.Nuttall said, "I’ve been using this over the past month as I worked in the emergency department on several patients, so I use it on any patient who has COVID-like symptoms."In addition to protecting healthcare staff, Nuttall said he wants the digital stethoscope to be used for things like telemedicine, treating patients in isolation, and in developing countries that don't have access to healthcare.Instructions on how to build a 3D printed digital stethoscope can be found here and the accompanying Stethogram iOS app is available here.This story originally reported by Jordan Hogan on fox13now.com. 1961

CLINTON, Mo. — A Clinton police officer died and two other officers were hurt in a shooting at a home in the small Missouri town late Tuesday evening.Ofc. Christopher Ryan Morton died in the shooting, according to the Missouri State Highway Patrol. The 30-year-old had been with the department, then returned to the force after a shooting?last year killed Clinton police officer?Gary Michael.In a news conference early Wednesday morning, Highway Patrol Sgt. Bill Lowe said officers responded to a 911 call at 9:20 p.m. local time in which a woman was screaming in the background. When police arrived at the home, Sgt. Lowe said a man fired at the responding officers from inside the residence.The officers then returned fire and went inside the home. When they went inside, the suspect shot and killed one officer and hurt two others.The officers got out of the home and crews took them to the hospital.The suspect then barricaded himself inside.Around 12:10 am, the Highway Patrol SWAT team went into the home and found the suspect dead. It is not yet known if the suspect died as a result of the gun battle with police or if it was self-inflicted.The injured officers were receiving treatment at hospitals in the Kansas City area, and according to Sgt. Lowe, their injuries are not life-threatening."The Clinton Police Department is a well respected police department," said Sgt. Lowe. "They will forge on, but they will need help along the way. We are all saddened by this tragic event. It's one of those things that we realize can happen, but when it does happen, it definitely hits home."Cassie Toliver, who lives near where the shooting took place, said police vehicles, sirens and lights quickly filled the streets and law enforcement barricaded the area from both sides. In a phone interview with Scripps station KSHB in Kansas City just after 11 p.m. Tuesday night, Toliver said she could hear gun shots around 10:50 p.m. Tuesday."We can still hear shots being fired," said Toliver. "We don’t whether that’s the shooter or the cops because it’s so dark outside.”The two women who called 911 were not injured, Sgt. Lowe said. "We will be speaking with them right away."Sgt. Lowe said Morton had been with the department for a while."It's hard to put into words what you go through when you have an officer killed in the line of duty," said Sgt. Lowe.Tuesday night's shooting happened exactly seven months after Clinton police officer Gary Michael was shot and killed in the line of duty. "It's just another tragic event for this community and this police department," Sgt. Lowe said. "They've endured a lot and they are going to endure more. Everyone's thoughts and prayers would be appreciated."Sgt. Lowe said the officer who was shot and killed Tuesday night came back to the department after Ofc. Michael was killed.This story will be updated as more information becomes available.   3027

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