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The drug ketamine is used as an anesthetic, a pain reliever or even a club drug. But now, a ketamine-like drug could soon be approved by the FDA to help people fighting severe depression. Sally Owens is one patient undergoing ketamine treatment. “You feel secure in and grounded, even though you're in a dream state,” Owens says of the treatment. “And in an hour, you come out of it and you're feeling better.” The retired nurse started getting IV ketamine treatments after fighting depression with antidepressants for most of her adult life, with no success. But after two sessions at Vitalitas, a Denver ketamine infusion center, she saw results. “I was doing more things around the house and getting out and and doing more things with friends,” she says. Owens says she’s excited to hear the FDA is considering a more accessible, less potent nasal spray similar to ketamine. “You could essentially think of esketamine as half of ketamine,” describes Dr. Roman Langston, who treats patients with ketamine. Esketamine would be for people with severe depression who haven't benefited from at least two different therapies, the doctor says. 300 million people around the world are affected by severe depression. Drug makers hope the spray can help 30 to 40 percent of patients, who don't respond to antidepressants. Antidepressants can take weeks to take effect, while they say nasal spray benefits start after four hours. Dr. Langston says FDA approval could make more people comfortable using the drug, commonly known as a party drug. Right now, it's not covered by insurance. Sessions can range from 0 to 0 for a session. “If they qualify for coverage through their insurance company, maybe it's a copay, and they can give it a try and it could make a huge difference in their life,” he says.Dr. Langston says it remains to be seen what the long-term consequences of esketamine are. 1907

A Phoenix couple is accused of forcing a day laborer at gunpoint to have sex with the female suspect, police say.Phoenix police on April 8 responded to a call from a man saying he was sexually assaulted by a couple at a home. According to court documents, Brenda Acuna Aguero, 39, picked up a day laborer and told the man her husband needed help moving some items at their home. When they arrived at her house, Aguero reportedly told the man that, "it was her fantasy to have sex with a laborer." The victim initially thought Aguero was teasing, but when he realized she wasn't, he told her he was not going to have sex with her. At that point, police say, the woman's husband, 45-year-old Jorge Francisco Valenzuela, came into the room with a rifle. Valenzuela allegedly placed the rifle on the victim's chest, and "told him he was going to have sex with his wife, or he would shoot him."The victim had sex with Aguero as Valenzuela filmed video and took pictures, and allegedly directed the victim to different sexual positions.Police say Valenzuela later stole the victim’s Mexican visa and driver's license, and forced the victim to call his wife so Valenzuela could get her phone number.Valenzuela allegedly told the victim to come back the next day to get his visa and license and have sex with Aguero. He then threatened to send the video to the victim's wife if he didn't comply, records show.Later the same day, Valenzuela allegedly demanded the victim returned to his home for another sexual encounter. When the victim arrived with a friend, Valenzuela sent the pictures to the victim’s wife.The victim contacted police, who arrested Valenzuela and Aguero at their home. They both allegedly admitted their actions, with Valenzuela saying they had done this before with about four other men.They are being held on a 0,000 bond for sexual assault. 1871

A federal judge in California blocked the new Trump administration asylum rule that dramatically limits the ability of Central American migrants to apply for asylum if they enter the United States by land through Mexico. Hours earlier, another federal judge in Washington DC issued the opposite ruling in a related case and refused to block the new restrictions. Federal District Judge Timothy Kelly, appointed by Trump, said Wednesday that the plaintiffs did not reach the threshold of irreparable damage. The ruling is specific to a temporary restraining order. The procedures will continue for a preliminary requirement. "This new rule is probably not valid because it is inconsistent with existing asylum laws," Judge Tigar wrote in California. Tigar, appointed by Obama, previously blocked President Donald Trump's asylum ban. The failures arrive a little more than a week after the regulation took effect. 923

WASHINGTON (AP) — The Supreme Court has agreed to decide a lawsuit that threatens the Obama-era health care law, but the decision is not likely until after the 2020 election. The court said Monday it would hear an appeal by 20 mainly Democratic states of a lower court ruling that declared part of the statute unconstitutional and cast a cloud over the rest. This will be the third time the Supreme Court has heard a case over the Affordable Care Act, sometimes called Obamacare. In the other two cases, the court upheld the heart of the law. Defenders of the ACA argue that the issues raised by the case are too important to let the litigation drag on for months or years in lower courts and that the 5th U.S. Circuit Court of Appeals in New Orleans erred when it struck down the health law's now toothless requirement that Americans have health insurance.The new case stems from tax legislation that was passed in 2017 that left the health insurance mandate in place but eliminated the financial penalty for not buying insurance. Republican-led states then sued, claiming the removal of the mandate was unconstitutional.As the case makes its way through the court system, a major focus of the Democratic presidential race has been on what should be done to provide healthcare to the most people. Sen. Bernie Sanders has proposed “Medicare for All,” while former Vice President Joe Biden has suggested adjusting the ACA, adding a public option. 1461

"Goldfinger" actress Tania Mallet has died at age 77, prompting messages of condolence from James Bond fans.A cousin of British actress Dame Helen Mirren, Mallet played Tilly Masterson alongside Sean Connery's Bond in the 1964 classic. Her death was announced on the official 007 Twitter account."We are very sorry to hear that Tania Mallet who played Tilly Masterson in GOLDFINGER has passed away," the tweet said. "Our thoughts are with her family and friends at this sad time."Born in Blackpool to father Henry and Russian mother Olga Mironoff, according to a biography on 588