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At a small store off a two-lane road in rural South Carolina, "lightning struck," the excited mayor of Simpsonville said Wednesday.Mayor Janice Curtis said she found out from a reporter that the winning ticket in the .537 billion Mega Millions drawing had been sold in her town.According to the mayor, the journalist asked, "How do you feel about this happening in little ol' Simpsonville?' And I about fell out. I had no idea. Can you believe it? One ticket! Here!"Simpsonville is the kind of town where farm fields are giving way to housing developers. The city grew from 18,000 to 22,000 people as the Greenville suburbs encroached over the past seven years. 671

As we're all focused on the current rollout of the COVID-19 vaccine, a technology known as thin-film freezing is getting a lot of attention. It's groundbreaking and could change the way we administer drugs or use medicine in general.You've probably heard about the need to keep the COVID-19 vaccine cold. It has to be so cold, in fact, that the shipment and transport are challenging. Well, what if that vaccine could be turned into powder?“What we’ve most recently been working on is the elimination of cold chain by storing as a powder, a dry powder where the drug is much more stable than if it was stored as a liquid or as a frozen liquid,” said co-inventor Dr. Robert Williams.Williams said it would eliminate the need for extreme cold storage and transport. The technology isn't new. He got a research grant and came up with it about 15 years ago.Williams, who is also a pharmacy professor at the University of Texas in Austin, said they were working on the technology and its multiple uses when the pandemic hit. And all of a sudden, they got a lot of attention.“We have published over 70 papers on the technology and using it for different products- it’s quite a mature process," Williams said. "We developed it because with other vaccines, the majority of the vaccine cost is in wastage because of this cold chain issue, so we published several key papers where we showed our thin-film freezing technology would protect vaccines - and you wouldn’t need cold chain storage.”Glenn Mattes, President, and CEO of TFF Pharmaceuticals added that the powders can be converted to topical preparations and they are currently working with the US Army to take some of the preparations and would then administer them directly through the eye.TFF is launching thin-film freezing into development through the FDA process. “I use the term ubiquitous because it is and disruptive because it is,” Mattes said. He added that they've explored their technology in the cannabinoid realm. But, as for the COVID vaccine, they're aiming for a second-generation usage.“To truly eradicate the pandemic, you have to have a global response," Mattes said. "The companies we’ve been speaking to certainly recognize the broad utilization of the technology but the application to the developing world, rural area, remote areas, where you can take a powder and inhale it or take the powder and reconstitute it has tremendous potential."Experts say it is only just the beginning as they launch their technology into a new world. 2511

ATLANTA, Ga. – A top official with the Centers for Disease Control and Prevention (CDC) said Wednesday that experts are seeing a “distressing trend” as coronavirus cases surge across the United States, particularly in the Midwest.“Unfortunately, we're seeing a distressing trend here in the United States,” said Dr. Jay Butler, Deputy Director for Infectious Diseases. “Smaller, more intimate gatherings of family, friends and neighbors may be driving transmission as well, especially as they move indoors.”Butler also urged Americans to continue taking the necessary precautions to prevent the spread of the coronavirus, like practicing social distancing, washing your hands and wearing masks.“I recognize we are all getting tired of the impact that COVID-19 has had on our lives, we get tired of wearing masks, but it continues to be as important as it’s ever been and I’d say it’s more important than ever as we move into the fall season.”Butler made the comments during a press briefing with CDC Director Dr. Robert Redfield and Health and Human Services (HHS) Secretary Alex Azar.CDC, HHS give an update on COVID-19 response https://t.co/YxLSMGZgbs— Reuters Science News (@ReutersScience) October 21, 2020 During the briefing, Azar and Redfield discussed Operation Warp Speed, a partnership initiated by the Trump administration to accelerate the testing, supply, development and distribution COVID-19 vaccines, therapeutics and diagnostics.The goal of partnership is to produce and deliver 300 million doses of a safe and effective vaccine with initial doses available by January 2021, according to the HHS website.Azar provided an updated timeline on when we can expect vaccine to be distributed and who will receive the first doses. According to him, a vaccine would be widely available by late March or early April.“We expect that we would have by the end of this year, enough vaccine that is FDA authorized, to be able to vaccinate all of our vulnerable, the most vulnerable individuals,” said Azar. “Then by the end of January, we expect we’ll have enough to vaccinate all seniors as well as our health care workers and first responders. And by the end of March to early April, enough vaccine for all Americans who would want to take a vaccine.”Wednesday’s briefing comes as many states report increases in the number of COVID-19 cases. The U.S. has surpassed 8.3 million cases and more than 221,500 people have died across the nation from the disease, according to an ongoing tally by Johns Hopkins University.Experts are concerned there may be a major spike in cases during the fall and winter months, which will strain the country's health care system, which will also be caring for flu patients.With many people still struggling amid the pandemic, Congress and the Trump administration still have not come to a deal on another COVID-19 relief bill. As for the Senate, Majority Leader Mitch McConnell has signaled his chamber may not support the potential deal. 2983

AURORA, Colo – A man is giving a family a piece of their hero back after finding World War II dog tags on a job site he was working on.“They’re going into the mail today,” Michael Huber said in his office, surrounding by old photos and knick-knacks packed away in a box.Huber has all the respect in the world for a man he’s never met, but came across his name in the dirt.“Well, I was excavating on my jobsite,” Huber said. “I was getting rid of some trash and debris from years ago, and I pulled out a bucket and there was something shiny sticking out. I saw what it was and it was dog tags.”The name Gail Sheldon was engraved on the tags.“It said he got his shot in 1943,” Huber said. “Amazing. World War II dog tags.”Doing a little research, Huber found out who Sheldon was.“He was a captain and flew B-24 bomber planes,” Huber said. “He had several missions over Berlin, and he flew during D-Day. He was even shot down one time.”Huber was able to get into contact with Sheldon’s family after a couple of months. He found out from the family Sheldon died in 1990.Huber is now sending back the dog tags along with Sheldon’s pilot wings that he found with the tags. He packs up a box filled with old coke bottles and old squirt guns from that time that he found on the job site.“It could possibly be his family’s,” Huber said.Huber, who has also served in the U.S. Army, said he deeply respects Sheldon. Which is why it's important to send this memento back to the family.“Dog tags to me is part of a person’s being,” Huber said. “It’s a symbol of them giving up everything.” 1584

At least 29 people were killed during a week of severe weather conditions and devastating flooding in Italy, the country's interior minister said Sunday.Twelve people were confirmed dead on the island of Sicily on Sunday, including nine members of two families, the fire brigade announced on Twitter.The families were dining together when their house was submerged by water from a nearby river that suddenly overflowed.The fire brigade said its divers had found the bodies. Among the victims were two children, 1 and 3 years old.Italy's civil protection agency said it was still looking for a doctor who had been on his way to work at a hospital Saturday night and was missing.High winds and heavy rain have devastated parts of the country over the past week, causing the worst flooding in at least a decade in Venice, damages of more than 1 billion euros (.14 billion) in Veneto and landslides that have cut off villages, authorities said.The situation in Sicily is "dramatic," Prime Minister Giuseppe Conte said Sunday.Conte will call a cabinet meeting to announce a state of emergency in affected regions, he said at a press conference in Palermo, Sicily. 1168