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SAN DIEGO (KGTV) - After moving to San Diego almost three years ago, Derek and Terri Ruff are on a mission to experience everything the city has to offer. “Yes we are, it’s fantastic! We hardly leave the county, there’s just so much to do," said Derek.The couple moved here from New Mexico, and for nine years Derek's colon cancer seemed to be behind them. “I won’t say cancer-free, but I didn’t have any symptoms for years, until last May, whenever I came in for a checkup, and they discovered cancer again," said Derek.It was stage IV metastatic colon cancer.“It’s a lot. It’s a tough diagnosis, it’s really difficult to live through.”After three months of aggressive chemotherapy, Ruff's condition only got worse. His journey brought him to UC San Diego Health's Moores Cancer for a clinical trial, which unfortunately did not work. But he Ruff became a candidate for another trial involving natural killer cells created from stem cells.“These are patients who don’t have a lot of good options in terms of chemotherapy or immunotherapy," said Dr. Sandip Patel, a medical oncologist who is leading the trial at UCSD. Decades of research on natural killer cells have culminated in the new cancer treatment being developed by San Diego-based Fate Therapeutics.Fate is the first to mass produce cancer-killing cells from a type of stem cell called a human-induced pluripotent stem cell (iPSC). "The concept of utilizing the stem cells that are within us, within our blood factory, within our blood marrow, to create a master bank of cells that we can utilize to program in different ways to fight cancer with cellular immunotherapy."The off-the-shelf, iPSC-derived natural killer cell cancer immunotherapy received U.S. Food and Drug Administration approval to move into clinical trials in November 2018. Ruff is the first person in the world to receive the treatment and got his first dose in February.“Being the first is exciting but it was less so hearing that you have stage iv cancer and you don’t have much of a future, and now I feel hopeful, again," said Ruff.While it's too early to tell if the treatment is working, researchers are hopeful this treatment will one day help many cancer patients. 2212

SAN DIEGO (KGTV) — A woman says her ,000 custom road bike was stolen from her driveway last weekend while she was getting ready to go for a ride.Josie Fouts is a cyclist who recently competed with Team USA at the Para Pan-American Games in Lima, Peru.Due to the amputation of her left hand at birth, her bike requires custom elements including a modified handle and special braking mechanism.The frame is black and blue Fuji Supreme.Fouts said she had left the bike on her driveway on Saturday, Sept. 14 while she was getting ready to go on a ride. She had gone inside to put on her shoes but when she came back the bike was gone.“I heard the back wheel click.” Fouts remembered thinking, “I thought it was my friends coming to see me.”It wasn’t.Anyone with information about the bike is urged to call the Adams Avenue Bike Shop at 619-295-8500. 855

SAN DIEGO (KGTV) — A San Diego pilot is attempting a historic flight to promote global peace. Robert DeLaurentis will first be traveling to the South Pole and then to the North Pole, connecting the only two places on the planet where peace exists. "It's a mission of global peace. We like to say oneness. One planet, one people, one plane," said DeLaurentis.They have been working on upgrading the 1983 aircraft for several years now; DeLaurentis named it Citizen of the World. "It's like taking a classic car and turning it into a race car. It's been talking to us, letting us know what needs to be fixed or replaced," DeLaurentis says.It's not the first time DeLaurentis has attempted an ambitious journey. In 2015, he circumnavigated the globe, braving a failing engine at one point. "My dad says he'd prefer I have a country club membership than do these flights!" jokes DeLaurentis.But it was on that trip he learned no matter where you live, we're all more similar than we may think. DeLaurentis will be the first to complete the journey with this class of airplane. And will also be the first to use biofuel over the poles, which is better for the environment.He'll have a NASA experiment on board and will also be testing the air for pollutants every step of the way.DeLaurentis will face harsh conditions in the South Pole, like extreme winds and weather fronts. But despite the dangers, he says this is what he's meant to do."People work hard, and they get to the point where they decide they want to do some other things, for me, it's just to go out in the world and maybe make a difference. So I'll take my chances."The San Diego pilot is getting help from over 90 sponsors to make the trip a reality. He departs Saturday from Gillespie Field, sometime between 10 a.m. and 12 p.m.You can follow each minute of the journey through his website. 1863

SAN DIEGO (KGTV) -- An hours-long SWAT standoff involving a domestic violence suspect in Point Loma came to an end Thursday night. Police were called to the 2200 block of Caminito Pescado around 4:45 p.m. after receiving a call from a neighbor. Police say a woman who lives in the home ran to the neighbor’s house reporting that she and her 71-year-old husband got into a fight. Police and SWAT responded and found the man on the second floor balcony of the condo. After trying to get the 71-year-old down from the balcony, police say he ran inside before a gunshot could be heard coming from the home. Neighbor Jenny Taylor spoke with 10News on FaceTime, saying she could see officers lined up with their weapons drawn from her patio. She said she was ready for the worst, "let me move it so we can at least duck down really quick and hit the floor and run inside the house, so we left the screen door open and moved all the chairs out of the way."It was hours before police and SWAT packed up.Authorities later found the man dead inside. According to police, records show authorities had never been previously called to the home. An investigation into the incident is currently underway. If you're contemplating suicide, call the National Suicide Prevention Lifeline at 1-800-273-TALK (8255). There is also a crisis text line. For crisis support in Spanish, call 1-888-628-9454. 1388

SAN DIEGO (KGTV) - A San Diego woman known for helping others got the gift of a new smile Wednesday.Twyla Green got a life-changing surgery and a new set of teeth as the lucky winner of the Smile Again program."You can do anything as long as you put your mind to it,” Green said. “God sends people that will help you.”The initiative, hosted by Oral Surgery and Dental Implant Specialists of San Diego, offers the community suffering from poor oral health the opportunity to apply a free ,000 smile.They tell 10News Twyla was selected out of more than 200 San Diegans.Twyla says she’s lived her life taking care of other people; this opportunity is a way to help allow her to feel the confidence she helps others achieve. 731