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WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."
SYDNEY, Aug. 16 (Xinhua) -- People sitting in front of TV for hours on end could shorten their life expectancy by almost five years, according to an Australian study published on Tuesday by the British Journal of Sports Medicine.Researchers from the University of Queensland estimate that for every hour adults spend in front of TV, their life expectancy shortens by almost 22 minutes.Those who watched six hours a day lived 4.8 years less than those who don't watch TV.The study is the first in Australia to look into how TV habits affect longevity.The Australian researchers found that watching TV could have a similar negative impact on life expectancy to that of obesity, smoking and low physical activity."People don't realize how it all adds up," the study's lead author Dr. Lennert Veerman told the Australian Associated Press (AAP)."They should try not to watch too much TV and find alternative things to do, preferably things that are light activities," Veerman said.The study was based on data from the Australian Diabetes, Obesity and Lifestyle study and asked more than 11,000 people aged over 25 about their weekly TV viewing time.The study found that in 2008 Australian adults watched 9.8 billion hours of TV."These findings suggest that substantial loss of life may be associated with prolonged TV viewing time among Australian adults," the study said."TV viewing time may have adverse health consequences that rival those of lack of physical activity, obesity and smoking; every single hour of TV viewed may shorten life by as much as 22 minutes," it said."With further corroborative evidence, a public health case could be made that adults also need to limit the time spent watching TV."Australians are recommended to spend at least 30 minutes a day doing moderate-intensity physical activity to reduce an increased risk of developing cardiovascular disease.
BERLIN, June 5 (Xinhua) -- German authority said on Sunday that bean sprouts might be the "most convincing" source for the E. coli outbreak which has killed 22 people and infected more than 2,000 in the Europe.Gert Lindemann, Agriculture Minister of the state Lower Saxony, told reporters in a press conference that restaurants and food outlets where the cases of E. coli had been reported all had received shipments of the particular bean sprouts.A related company in the Uelzen region has been shut down and its products have been recalled, he said."It is the most convincing... source for the E. coli outbreak," Lindemann said. Although a conclusive laboratory analysis will not come out until Monday, current indications were strong enough to issue a public warning, he said.Authorities have been racing to track down the source of the pathogen since the outbreak, which has infected people in 12 countries - all of whom had once traveled in northern Germany. More than 600 of those infected have developed Hemolytic Uremic Syndrome (HUS), a potentially deadly complication attacking the kidneys.The source of E.coli was first thought to be the cucumbers from Spain, which has caused huge loses for Spain farmers. However, this conclusion was overthrown by Laboratory tests in Hamburg on Tuesday.
VIENNA, Aug. 11 (Xinhua) -- Austrian researchers have developed a method of using fungi and produced enzymes to split Polyethylene Terephthalate (PET) material into their initial state, enabling the recovery of all individual components, said the Austrian Center of Industrial Biotechnology (ACIB) Thursday in a press release.Enzyme is a special protein that acts as biological catalyst, for example, bacteria and fungi in the nature can break down long chain molecules.Researchers from the Technical University of Graz, the Technical University of Vienna and the Agricultural University of Vienna jointly found that efficient enzymes are capable to break and split PET into small fragments.With different methods, the researchers forced the fungi to overproduce their precious "split-tools" after they are modified and improved by genetic engineering.Through the new method developed by the ACIB, it is now possible to decompose the PET polymer to its initial monomers with high product quality and from this to produce new high-quality materials again.This circuit avoids waste and thus saves resources and is friendly to the environment, said Geog Guebitz, head of the Research Department on Enzymes and Polymers in the ACIB.He further explained that the ACIB has established a partnership with some industrial enterprises to carry out application experiments. From the current splitting time of 24 hours, the researchers expect to shorten the whole process to "a few hours," he added.PET is a common plastic material in the polyester family, widely used in the textile industry. PET film is mainly used in electrical insulation materials, which can be also used for production of film, X-ray films and computer taps, even to produce plastic bottle and other blow molding products.
SAN FRANCISCO, July 20 (Xinhua) -- Google announced on Wednesday that it has reached a deal with author J.K. Rowling to launch the series of Harry Potter ebooks on Google's platform.When the series of Harry Potter ebooks launch on Pottermore.com in early October, the bestsellers will be available in the United States via Google eBooks platform, said Google in a blog post.When customers buy a Harry Potter ebook from Pottermore.com, they will be able to choose to keep it in their Google's online library in the cloud, as well as other e-reading platforms.Google said Google eBooks can be read on most devices with a modern browser, through Google apps for iOS and Android smartphones and tablets, and on more than 80 e-readers.Meanwhile, Rowling will continue to issue announcements via YouTube, as she announced Pottermore.com in June.The two sides also agreed to make Google Checkout the preferred third-party payment platform for all purchases made on Rowling's Pottermore.com.Pottermore.com, which will be launched on July 31, will sell ebook and audiobook versions of the seven Harry Potter novels, as well as additional content including background details and settings.According to The Times, the Harry Potter brand value is estimated to be more than 15 billion U.S. dollars. The deal could make Google move some e-reader customers from competitors like Amazon, whose e-reader Kindle does not support Google eBooks.