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Scientists, doctors and the public are eagerly waiting to hear how effective a COVID-19 vaccine will be and how soon it could be available to everyone. But when the vaccine is ready, some will be racing to be first in line, while others will be cautiously waiting to see how it plays out."Only about half of people get a flu vaccination polls are showing. In terms of the coronavirus, that’s saying that a third to maybe as much as half of the population will not want to get a vaccine," said Arthur Evans, the CEO of the American Psychological Association.Evans is concerned about whether people will be willing to get the COVID-19 vaccine when it comes out. How people are educated about the upcoming vaccine will be crucial."Right now, I think there are a lot of people who want to take a vaccine and to get a vaccine, but if people feel that this has been rushed, that they don’t feel all of the normal safety measures have been taken, it's going to be much harder for people to take that step," explained Evans.Dr. Bali Pulendran, a pathology, microbiology and immunology professor at Stanford University, says just because a COVID-19 vaccine is being expedited doesn't mean it's any less safe."It's a very established, lengthy process. It’s expedited now because of certain technologies such as the mRNA technology that really helps you accelerate this process," said Dr. Pulendran.He says the creation of a vaccine is rigorously tested, first with mice, then primates, and finally, humans. Tens of thousands of people are currently choosing to participate in COVID-19 vaccine trials."And so, this is a development and paradigm that has served vaccinology really well. It's really served it well in terms of enabling the licensure of some 20 or more vaccines," said Dr. Pulendran.Dr. Pulendran says every year, the flu vaccine varies in efficacy. For a good year, it could be 90 percent protective, while the next year, the flu shot may only be 10 percent effective. The COVID-19 vaccine is expected to be 60 percent effective."I think for me, personally, if I saw a vaccine coming out in the next year or so that had a 60 to 70 percent efficacy, that to me would be very encouraging," said Dr. Pulendran.The public, though, may still need some convincing."One of the hardest things for the general public to embrace is the idea of probability. We like to know definitively if something works or not,” said Evans. “The reality is that a vaccine is a probabilistic issue. It's highly likely that you won’t contract, whatever the condition is, but it’s not 100 percent."Evans says the key will be in how the vaccine is marketed to the American public.Dr. Pulendran hopes any positive data and outcomes of the COVID-19 vaccine trial will encourage as many people as possible to get the vaccine when it comes out. 2823

SANTA ANA, Calif. (AP) — Orange County’s new interim health officer says he will lift a requirement that residents wear face coverings in public and instead recommend they do so to help reduce the spread of the coronavirus. The change comes three days after the previous health officer abruptly resigned following threats she received over her order requiring masks as the county allowed more businesses to reopen. Residents have railed against the requirement at public meetings. Los Angeles and San Diego counties have similar requirements. The head of the Orange County Medical Association says using a mask is a small sacrifice to protect others. 658

Saudi Arabia has confirmed the death of missing Saudi journalist and Washington Post columnist Jamal Khashoggi in an announcement on Saudi state TV.The Saudis have set up a commission that will investigate Khashoggi's death and will have one month to release a report, according to state TV. The commission will consist of national security officials, the foreign ministry and the interior ministry.Discussions between Khashoggi and those who met him during arrival at the consulate in Istanbul led to an argument and physical altercation that led to his death, the state TV report said.A total of 18 Saudi nationals have now been detained for investigation, the Saudi Press Agency reported.In the announcement on Saudi State TV, it said a royal order has been issued to release Maj. Gen. Ahmed al-Asiri from his duty as the deputy of the intelligence services.Asiri was believed to be the chief architect of the war with Yemen. He was previously the Saudi-led coalition spokesman in the kingdom's war against Yemen's Houthi rebels.The two-star general's position as spokesman made him a household name and he was soon part of the Crown Prince's inner circle.According to several sources, he chose the team involved in Khashoggi's disappearance.In their announcement the Saudis expressed deep regret over Khashoggi's death and the "painful developments" in the case. They affirmed the "commitment of the authorities in the Kingdom to bring the facts to the attention of the public and to hold accountable all those involved," according to a CNN translation of the announcement.Khashoggi disappeared October 2 after going to the Saudi Arabian consulate in Istanbul to obtain paperwork to marry his Turkish fiancée, Hatice Cengiz.She raised the alarm to police just before 5 p.m. on October 2 -- three and a half hours after the journalist entered the consulate. At that time she was still waiting outside.Turkish officials now say they believe that 15 Saudi men who arrived in Istanbul on October 2 were connected to Khashoggi's death. At least some of them appear to have high-level connections in the Saudi government. 2127

SAN YSIDRO (CNS) - A pedestrian was struck and killed by a van early Monday morning while he was attempting to cross a San Ysidro street, police said.It happened shortly before 1:10 a.m. in the 400 block of East San Ysidro Boulevard, San Diego police Officer John Buttle said.The unidentified man, believed to be in his 40s, stepped off the east curb of East San Ysidro Boulevard and was struck by a 64-year-old man driving a 1999 Chevrolet Astro van in the northbound lanes, Buttle said.The victim was pronounced dead at the scene, Buttle said.The driver remained at the scene and cooperated with officers, Buttle said.Alcohol or drugs were not believed to be factors in the collision, Buttle said. It was being investigated by traffic officers. 754

SAN MARCOS, Calif. (KGTV) — City officials in San Marcos held a ground-breaking ceremony Wednesday for a 0-million infrastructure project, designed to mitigate flooding.The project will help manage flooding along the San Marcos Creek using two new bridges and channelize parts of the creek. One bridge will be on Brent Avenue and the other will be on Via Vera Cruz. Both bridges will also include bike and pedestrian paths. The project is scheduled to begin in early 2020 and will take about two years to complete. For alerts and information, visit the City of San Marcos website. 591