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BUDAPEST, June 25 (Xinhua) -- Visiting Chinese Premier Wen Jiabao made a five-point proposal here Saturday to enhance China's cooperation with countries in Central and Eastern Europe.When delivering a speech at the China-Central and East European Countries Economic and Trade Forum, Wen said China cherished its longstanding and deep friendship with the countries in the region."Over the past several decades, although the international situation and the domestic situations of both sides have undergone big changes, we have always enjoyed mutual respect, mutual trust, mutual understanding and mutual support," Wen said. Chinese Premier Wen Jiabao addresses the China-Central and Eastern European Countries Economic and Trade Forum in Budapest, Hungary, June 25, 2011.He said cooperation in various fields between the two sides had made tremendous progress, referring to the rapid growth of two-way trade, the burgeoning of mutual investment, the expansion of cooperation areas and the improvement of cooperation mechanisms.China encouraged its companies to "go global" and saw Central and Eastern Europe as a strategic priority, the Chinese leader said, adding that his current visit was "both a journey of friendship and a journey of cooperation."

WASHINGTON, Aug. 4 (Xinhua) -- Observations from NASA's Mars Reconnaissance Orbiter have revealed possible flowing water during the warmest months on Mars, the U.S. National Aeronautics and Space Administration (NASA) announced Thursday.Dark, finger-like features appear and extend down some Martian slopes during late spring through summer, fade in winter, and return during the next spring. Repeated observations have tracked the seasonal changes in these recurring features on several steep slopes in the middle latitudes of Mars' southern hemisphere."The best explanation for these observations so far is the flow of briny water," said Alfred McEwen of the University of Arizona, Tucson.McEwen is the principal investigator for the orbiter's High Resolution Imaging Science Experiment and lead author of a report about the recurring flows to be published in Friday's edition of the journal Science.Seven such sites on the planet have been confirmed, with 20 more possible, McEwen said."What makes these new observations so interesting is they occur at much lower latitudes where temperatures are much warmer and where it's actually possible for liquid water to exist," said Arizona State University geophysicist Phil Christensen, one of the scientists who studied the images beamed back from the orbiter.The study does not prove water exists, but identifies it as the best explanation. It's worthwhile to think about alternative reasons for these observations, but none seems to fit as well as briny water, McEwen said."I think it's going to be laboratory experiments on Earth that give us the best confirmation or refutation," he said.

WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."

LOS ANGELES, July 28 (Xinhua) -- Mainly due to rampant obesity, Americans' life expectancy is one-and-a-half-year shorter than that of Western Europeans on the average, according to a new study published on Thursday.But 40 years ago, Americans could expect to live slightly longer than Europeans, said the study jointly conducted by researchers from University of Southern California (USC), the Harvard School of Public Health and the RAND Corp., a non-profit think tank.In addition to Western Europeans, Americans also die younger than the residents of most other developed nations, according to the study appearing in the July issue of Social Science & Medicine.The life-expectancy disparity, which begins around the age of 50, stems from higher levels of middle-age obesity and obesity-related chronic diseases, such as hypertension and diabetes, said the study.In the first half of the last century, average life expectancy increased by saving more babies, said author Dana Goldman, director of the Schaeffer Center for Health Policy and Economics at the USC."But now it is reduction in mortality among the elderly, rather than the young, that propels increases in life expectancy," he said. "The question is whether 'being American' is an independent mortality risk factor."If 50-year-old U.S. adults could be as healthy as Europeans, it could save Medicare and Medicaid 632 billion dollars by 2050, the study said.Though the transition to better health initially raises expenditures, the researchers estimate that by 2050 healthcare savings from health improvements among the middle age could total more than 1.1 trillion dollars."The international life expectancy gap appears much easier to explain than gaps within countries: there is no American-specific effect on longevity beyond differences in disease at age 50," said Darius Lakdawalla, an associate professor in the USC School of Policy, Planning and Development.