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SAN DIEGO (KGTV) - Caltrans will paint new stripes on Interstate 15 this week that will require lane and ramp closures through Thursday.Monday and Tuesday closures will take place from 9 p.m. to 5 a.m. and include: 222

SAN DIEGO (KGTV) - Could you feed yourself on about per day? The San Diego Hunger Coalition is encouraging San Diegans to take part in the annual CalFresh Challenge to raise awareness about food insecurity. CalFresh public assistance allots .07 daily in food benefits, according to SDHC. The system, known nationally as SNAP, helps those in need but it is insufficient for helping people meet basic needs, SDHC says. During the CalFresh Challenge, participants must spend no more than .35 for five days on all meals, drinks, and snacks. During the week, participants must not accept free food. San Diego Hunger Coalition wants participants to post about the experience on social media with the hashtag #CalFreshChallenge. Participants are also asked to donate to SDHC. 784

SAN DIEGO (KGTV) - City of San Diego crews spent Monday preparing for the first significant rainfall since May. “With the first rains of the season in the forecast, crews are busy clearing critical drains, putting no parking signs along flood prone streets and installing backup generators for the City’s crucial storm water pump stations,” the City of San Diego posted on twitter. "During the rains, 15 crews from the City's Storm Patrol will be actively patrolling, monitoring areas in the city and responding to instances including temporary flooding and downed trees or tree branches," added city spokesman Anthony Santacroce.The heaviest rain is expected overnight Tuesday through the day Wednesday, according to 10News meterologist Megan Parry. RELATED: Megan's Forecast: Hot today followed by rain“Rainfall accumulations will average between 1 to 1.50" for the coast and valleys with some mountain areas getting closer to 2" while the deserts will pick up between .10 and .25" of rain,” Parry said. San Diego most recently had measurable rainfall on Sept. 28 but the amounts were small, Alex Tardy of the National Weather service reported. The last time “people would have had puddles in their yards” was May, Tardy said. The City of San Diego said Monday that up to 10 sandbags per person would be available at the following locations for anyone with proof of residency. Standley Recreation Center, 3585 Governor Dr., University City Robb Athletic Field, 2525 Bacon St., Ocean Beach Golden Hill Recreation Center, 2600 Golf Course Dr., Golden Hill MLK Recreation Center, 6401 Skyline Dr., Skyline Scripps Ranch Recreation Center, 11454 Blue Cypress Dr., Scripps Ranch North Clairemont Recreation Center, 4421 Bannock Ave., Clairemont Allied Gardens Recreation Center, 5155 Greenbrier Ave., Allied Gardens San Ysidro Community Activity Center, 179 Diza Rd., San Ysidro City Heights Recreation Center, 4380 Landis St., City HeightsSnow is also expected in certain parts of Southern California. #Snow? say what? it is hot right now, yes offshore flow from the Baja system continues but a cold polar storm is dropping down from the north for Tuesday and Wednesday and the 2 will merge for rain, thunder and then cold and mountain snow on Wednesday! #CAWX pic.twitter.com/bj4Bp4VE7n— NWS San Diego (@NWSSanDiego) November 18, 2019 2341

SAN DIEGO (KGTV) — Apple says it will temporarily close all of its California storefronts, as the number of coronavirus cases surge in the state, according to multiple media reports.The company's Golden State locations, including stores in Carlsbad, Chula Vista, Escondido, and two in San Diego, were all listed online as "temporarily closed" on Saturday.Apple says each store will be open for pickup of existing online orders, previously scheduled in-store Genius Support appointments, and previously reserved one-on-one shopping appointments made through Tuesday, Dec. 22.No date was listed online for when the stores would fully reopen.The closures come as California continues to see a surge in COVID-19 cases. Both the Southern California and San Joaquin Valley regions hit 0% ICU bed capacity and the state reported more than 43,600 new virus cases on Saturday. 875

SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

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