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LONDON (AP) — Scientists at Oxford University say their experimental coronavirus vaccine has been shown in an early trial to prompt a protective immune response in hundreds of people who got the shot. British researchers first began testing the vaccine in April in about 1,000 people, half of whom got the experimental vaccine. Such early trials are usually designed only to evaluate safety, but experts were also looking to see what kind of immune response was provoked. In research published Monday, scientists said that they found their experimental COVID-19 vaccine produced a dual immune response in people who got the shot. 637

LOS ANGELES (AP) — A winter storm unleashed mudslides in Southern California wildfire burn areas and trapped motorists on a major highway, and the northern part of the state is bracing for more wet weather.Saturday's deluge loosened hillsides in Malibu where a major fire burned last year, clogging the Pacific Coast Highway with mud and debris.The scenic route remains closed Sunday as crews tow away trapped cars and clear lanes. No injuries are reported.Rainfall caused delays Saturday at San Francisco International Airport.Forecasters say another strong system will bring rain and snow to Northern California beginning late Sunday.Motorists are urged to use caution on mountain roads, where up to 4 feet (1.2 meters) of snow could fall in the Sierra NevadaPCH is now closed from Las Posas Rd in Ventura County to Encinal Canyon Rd in Malibu until at least Jan. 6 due to mudslides & flooding. Caltrans maintenance crews are on-scene assisting with clean up. Here are some photos from the PCH and Decker Cyn Rd, and PCH @ Yerba Buena Rd. pic.twitter.com/oIS4gbzRhC— Caltrans District 7 (@CaltransDist7) January 6, 2019 1133

LOS ANGELES (CNS) - Sheriff Alex Villanueva Tuesday said a weekend raid of "a massive underground party" at a vacant Palmdale residence -- despite health restrictions against large gatherings and a statewide curfew in place due to the coronavirus pandemic -- led to 158 arrests and the rescue of a 17- year-old victim of human trafficking.The Saturday night party in the 6300 block of West Avenue M-8 was allegedly organized by a teen promoter who was one of the people arrested when sheriff's deputies descended on the event, Villanueva said."Parties like these often involve drugs, prostitution, underage drinking and violence," Villanueva said at a news conference Tuesday morning outside the Hall of Justice, where he announced the 158 arrests as well as the rescue of the human trafficking victim and the recovery of six firearms from the location."We were able to rescue a girl who was present and categorized as a commercially sexually exploited child," Villanueva said.Involved in the law enforcement operation were personnel from the sheriff's Palmdale Station, the Human Trafficking Task Force, Operation Safe Streets Bureau, Aero Bureau, three mobile field forces and Los Angeles County Fire Department paramedics.According to Fox11, which had been tracking the 17-year-old promoter's alleged activities and was on scene when the raid occurred, 116 adults were cited and released for various misdemeanor offenses, while seven people were booked into jail. Another 35 juveniles were also cited and released. The arrests included three adults and two juveniles booked on suspicion of burglary, while one juvenile was arrested on a gun charge, the station reported.When stricter health orders were announced last week, including plans for the state's regional stay-at-home order that took effect late Sunday night, Villanueva said his department would continue to rely on the public's adherence to restrictions."Since March, we have continued to focus on education and voluntary compliance regarding health orders," he wrote on Twitter. "Moving forward, we will additionally be conducting targeted enforcement of super-spreader events."The Palmdale party was considered just such an event, Villanueva said at the news conference."As you can see, this was a flagrant violation of the governor's health order," Villanueva said. "But also please understand, even without the health order, these actions were criminal in nature."Villanueva said COVID-19 protocols were maintained by the law enforcement personnel, including providing those who were detained with protective masks.Sheriff's Capt. Ron Shaffer said the homeowner did not give permission for the residence to be used for such a gathering."They were looking to rent it to a family," Shaffer said.According to Fox11, the residence used for the party was up for rent, but the party organizers were allegedly in the home illegally.Los Angeles County and state health restrictions in place due to the coronavirus ban gatherings with people from different households. State health orders that were in place on Saturday also included an overnight curfew, barring people from gathering with others between 10 p.m. and 5 a.m. 3191

LOS ANGELES (AP) — Warner Bros. says it is delaying the release of Christopher Nolan's sci-fi thriller "Tenet" until Aug. 12, the latest delay for a film that many theater owners were hoping would kick-start the coronavirus-delayed summer season. The delay moves "Tenet" out of July, a month many theater chains had been eyeing reopening. The delay comes as coronavirus cases are surging in many U.S. locales. Warner Bros. stressed the need for flexibility when the film is released. It will now arrive on a Wednesday, which the studio says it hopes will allow it to find an audience. 592

LOS ANGELES (CNS) - Three men were named Wednesday in a Los Angeles federal grand jury indictment that alleges they distributed narcotics, including counterfeit pharmaceutical pills containing fentanyl, that resulted in the overdose death of hip-hop artist Mac Miller.Cameron James Pettit, 28, of West Hollywood; Stephen Andrew Walter, 46, of Westwood; and Ryan Michael Reavis, 36, a former West Los Angeles resident who relocated to Lake Havasu, Arizona, earlier this year, are charged with conspiring to distribute controlled substances resulting in death and distribution of fentanyl resulting in death.Each of those counts carries a mandatory minimum sentence of 20 years in federal prison and a potential sentence of life without parole, according to the U.S. Attorney's Office.Walter alone is additonally charged with being a felon in possession of ammunition, which, if he were to be convicted, would result in a sentence of up to 10 years in federal prison.Court documents allege the three defendants distributed narcotics to 26-year-old Malcolm James McCormick -- who recorded and performed under the name Mac Miller -- two days before the entertainer suffered a fatal drug overdose in Studio City on Sept. 7, 2018.The Los Angeles County Medical Examiner-Coroner later determined that Miller died of mixed drug toxicity involving fentanyl, cocaine and alcohol.According to the indictment, late on the night of Sept. 4, Pettit agreed to supply the rapper with 10 ``blues'' -- a street term for oxycodone pills -- as well as cocaine and the sedative Xanax. But instead of providing Miller with genuine oxycodone when he made the delivery during the early morning hours of Sept. 5, Pettit provided counterfeit oxycodone pills that contained fentanyl -- a powerful synthetic opioid that is 50 times more potent than heroin, according to the indictment.The indictment alleges that Pettit ordered the fentanyl-laced pills from Walter, and then Reavis delivered the narcotics to Pettit. Investigators believe that Miller died after snorting the counterfeit oxycodone pills containing fentanyl allegedly provided by Pettit. While another individual supplied Miller with other drugs prior to his death, those narcotics did not contain fentanyl, prosecutors said.Less than one month after Miller's death, Walter agreed to sell Pettit another 10 blues, according to the indictment, which also alleges other drug deals between the two men, with one as recent as Aug. 30. The indictment further alleges that Reavis was involved in drug trafficking activities in June and quotes a text message he sent after realizing he was negotiating a narcotics transaction with an unknown person that reads, in part: ``People have been dying from fake blues left and right, you better believe law enforcement is using informants and undercover to buy them on the street ... they can start putting (people) in prison for life for selling fake pills.''U.S. Attorney Nick Hanna said it has become ``increasingly common for us to see drug dealers peddling counterfeit pharmaceuticals made with fentanyl. As a consequence, fentanyl is now the number one cause of overdose deaths in the United States.''Hanna alleged that the three defendants continued to sell narcotics after Miller's death, ``with full knowledge of the risks their products posed to human life.''Special Agent in Charge William D. Bodner of the Drug Enforcement Administration's Los Angeles Field Division warned that counterfeit pharmaceutical pills are especially dangerous because users are unable to verify what they are ingesting.``The tragic death of Mac Miller is a high-profile example of the tragedy that is occurring on the streets of America every day,'' Bodner said, adding that the indictment ``highlights the efforts of DEA agents, local law enforcement officers, and prosecutors who work tirelessly to bring dangerous drug dealers to justice.''Pettit, who was previously ordered detained after being charged in a criminal complaint with distributing narcotics to McCormick, is scheduled to be arraigned in downtown Los Angeles on the indictment on Oct. 10.Walter was arrested on Sept. 23 on a criminal complaint alleging conspiracy to distribution narcotics, and he was also ordered held without bond. Walter also is scheduled to be arraigned on the indictment Oct. 10.Reavis, who was taken into federal custody in Arizona on Sept. 26 on charges of being a felon in possession of a firearm, is currently in custody and is being transported to Los Angeles by the U.S. Marshals Service. 4553