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SAN DIEGO (KGTV) — Researchers at UC San Diego Health are now looking for volunteers to participate in a COVID-19 clinical trial, starting locally next week.Oxford-AstraZeneca’s vaccine clinical trials will take place in 36 states across the country.“This is the second vaccine trial for the prevention of COVID-19, and like the first, it is a trial of 30,000 individuals nationally,” said Dr. Susan Little, a professor of Medicine and UCSD and the lead on this trial.Little said UCSD researchers hope to enroll about 1,600 people in eight weeks to participate in the trial.“Eighteen or older, in generally good health, but with underlying conditions that put them at greater risk for COVID-19,” she said. “Or people with increased risk of acquiring COVID-19 because of their professions or where they live.”Little said a bus would act as a mobile vaccine clinic. The bus will stop in parking lots in communities that have been historically underrepresented in medical research or disproportionately affected by COVID-19.“We’re going to focus on communities most impacted, the South Bay, East County, underserved communities and communities that have been hardest hit by COVID-19 those with the highest rate of infection in the community,” she said. “It’s a series of two vaccines, a month apart, people will be prescreened over the phone, and then they’ll be vaccinated on day one and day 29. Then they’ll be followed for two years thereafter.”In Phase 1 and Phase 2 clinical trials, Little said the vaccine proved to be safe.“We know that it’s safe in the sense that it causes local tenderness, some mild fatigue headache. Side effects went away in about one week,” she said. “This will be placebo-controlled, so I won’t know, and the participants won’t know whether they got a vaccine or placebo.”She said for every one person who gets the placebo, two people will get the vaccine.If people develop COVID-19 symptoms during the trial, two other mobile wellness clinics will be available for treatment.“Anybody who develops symptoms that are worrisome to COVID, we will come see them in our wellness vehicles and test them for COVID. The most important thing is to assess the sort of severity of their symptoms and determine whether they’ve developed COVID while on the study,” she said.Little said the goal is that there might be enough data to see if this vaccine is effective in six to nine months.“We have two ways out of this pandemic, treatment, and vaccines,” she said. “Our hope is through vaccine efforts like this, we won’t just find one vaccine that works, but we might find several.”Anyone interested in volunteering can learn more by clicking here, or calling 619-742-0433. 2696

SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) — San Diego County officials say they are taking additional steps regarding employers linked to outbreaks.Supervisor Nathan Fletcher said the county will update its public health order to state "entities shall notify employees of an outbreak that occurred at a physical location where they work."Fletcher added that the county believes most businesses are acting responsibly and notifying employees. He said that the county wants to make sure that employers are notifying every employee at the specific location an outbreak has been traced to, even if they may not have had close contact with a positive case.RELATED: San Diego County health officials warn local churches about holding indoor servicesThose employees will then be given instructions suggesting the next steps to take.The new order will be effective starting Thursday.Wednesday, the county reported 24 active community outbreaks, which is more than three times the county's trigger of seven community outbreaks in a week.The move was announced in addition to other measures to increase public health order compliance, including a compliance hotline and email, additional staff for egregious violations, outbreak inspections, and follow-up inspections.RELATED: San Diego based company behind rapid COVID saliva test“We’re in the process of setting up a health compliance hotline and email access,” said Supervisor Nathan Fletcher. “We’re bringing on additional staff to increase our ability to respond to those egregious cases those willful, blatant violations.”Fletcher said more information would be discussed at the County Board of Supervisors meeting Tuesday.“The current compliance effort really focuses on number one, the egregious cases we’ve seen. These are willful, blatant situations of defiance of public health orders,” said Fletcher. “We’ve issued three public health orders for closures we’ve issued three cease and desist letters.”San Diego County remains on the state’s watch list, meaning businesses were forced to close indoor operations due to the rise in COVID-19 cases and outbreaks.RELATED: County confirms coronavirus outbreak at Pacific Beach gymWhile some moved operations outside, others failed to comply. County officials learned of a COVID-19 outbreak reported at The Gym in Pacific Beach this week. Last week, Dr. Wilma Wooten, the county’s public health officer, sent a letter to The Gym asking for the immediate closure of indoor operations.The Gym continued to operate in violation of state and local health orders, according to the letter. Also, patrons were not wearing facial covering or social distancing, and that did not appear to be a requirement by the owners or operators, according to the letter.Wednesday, The Gym was closed to patrons. 2768

SAN DIEGO (KGTV) - San Diegans on the hunt for a job can now get some help from the Central Library in downtown.They're launching a "tie-brary" where people can borrow work necessities just like checking out a book. “It can be extremely costly, and you want to look professional and at your best when you go into these interviews, and that’s a burden that could set you back," said District 6 Councilman Chris Cate.Cate's office donated ,000 to help launch the tie-brary. “So if you want to check out a tie for a job interview that you're going to be having you can come down to the library and check out a tie, or check out a portfolio, or whatever you need for that job interview. And then you return it just like you're returning a book," said Cate. Cate's office will be collecting ties during April to continue helping with the effort. 851

SAN DIEGO (KGTV) -- San Diego Police are searching for a woman they say robbed a San Diego Wells Fargo bank. According to police, the woman entered the bank on the 9200 block of Miramar Road just before 6 p.m. Thursday. Police say the woman demanded money from the teller, who handed the suspect an unknown amount of cash. RELATED: Bank robber reportedly makes getaway on electric scooterThe woman then walked out of the bank, fleeing in an unknown direction. The suspect is described as a black woman in her mid-40s who is five feet, six inches tall with brown eyes and black and grey hair. She was wearing a baggie grey hoodie and dark pants. RELATED: FBI searching for man who reportedly robbed San Diego grocery store bankAnyone with information is asked to call Crime Stoppers at 888-580-8477. 807