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BEIJING, August 3 (Xinhuanet) -- Women who experience any form of gender-based violence are at greater risk of mental health disorders and related dysfunction and disability, according to Australian researchers Wednesday.Those who'd been through at least one form of this abuse -- which includes intimate partner violence, rape, sexual assault, or stalking -- were almost three times more likely to experience a mental health condition than those who were never victimized, according to Susan Rees, PhD of the University of New South Wales in Sydney, Australia, and her colleagues.Those who'd experienced three or four forms had an 11-fold greater risk, reported in the Aug. 3 issue of the Journal of the American Medical Association.The study "reveals a pattern of social disadvantage, disability, and impaired quality of life among women who have experienced gender-based violence," the researchers wrote.
LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.

BEIJING, July 26 (Xinhuanet) -- The breast cancer is more deadly to black women than to whites, a new study found.This finding was published online Monday on the "Journal of Clinical Oncology" in the United States.The study was done by the City of Hope, a Comprehensive Cancer Center in Duarte, California.The researchers collected data from more than 4,500 U.S. women in the 35-64 age group who were diagnosed with breast cancer.With the passing of more than eight years, the researchers found the black women have a three times death rate than white women, after taking obesity and other diseases into account."It’s been long known that breast cancer in African-American women is a far less common disease than in white women. But when it occurs, it seems to be more aggressive and harder to treat," said Dr. Lisa Carey of the University of North Carolina’s Lineberger Comprehensive Cancer Center.But why the situations varied by race, scientists are still exploring the answer.
JOHANNESBURG, June 1 (Xinhua) -- An estimated 2 million adolescents ages 10 to 19 are living with HIV, with 86 percent of them from sub-Saharan Africa, according to a global report on HIV prevention launched in Johannesburg on Wednesday.For the first time, the world gets to see the number of adolescents between the ages of 10 to 19 living with HIV in the report named Opportunity in Crisis: Preventing HIV from early adolescence to young adulthood.The report is a jointly publication by the United Nations Children's Fund (UNICEF), UNAIDS, the United Nations Educational, Scientific and Cultural Organization (UNESCO), the United Nations Population Fund (UNFPA), the International Labor Organization (ILO) , the World Health Organization (WHO) and World Bank.According to the report, people aged 15-24 accounted for 41 percent of new infections over the age of 15 in 2009. Worldwide, an estimated 5 million young people in that age group were living with HIV in 2009. Most of them live in sub-Saharan Africa. Globally, young women make up more than 60 percent of all young people living with HIV. In sub-Saharan Africa that rate jumped to 72 percent.Despite these challenges, the report acknowledges that some progress has been made in preventing new infections among young people."In many high-burden countries, HIV prevalence and incidence have declined among young people. While in 2001 there were 5.7 million young people living with HIV, the figure stands at 5 million (in 2009)," said the UNICEF eastern and southern Africa regional director, Elhadj As Sy, at the media briefing.He pointed that sexual transmission and injection drug use remain the major modes of transmission of HIV among young people. Early sexual debut, early pregnancy and early experiences with drug use all raise risks for HIV infection.The report reveals that unemployment and poverty are reported as the main reasons young people enter the sex trade. Worldwide, many young people driven by economic pressure, exploitation, social exclusion and lack of family support turn to commercial sex and injecting drug use.In 2001, the world made a commitment to reduce the prevalence of HIV among young people by 25 percent by 2010. The actual reduction achieved (from 5.7 million to 5 million) is 12 percent, and it represents less than half the target percentage."To avoid the current programming failures, we have to adopt a ' Continuum of Prevention Approach'." said Lina Mousa, deputy director of UNFPA Africa Regional Office."This continuum of prevention must be reflected in national HIV strategic plans, poverty reduction strategies and global fund proposals. This response must be developed with and for young people so that they own the response together with their communities," she added.To build this continuum of prevention for adolescents and young people, the reports outlined nine specific recommendations including providing young people with information and comprehensive sexuality education, strengthening child protection and social protection measures, engaging communities in shaping a positive social environment that promotes healthy behavior, establishing laws and policies that respect young people's rights.
HAVANA, Sept. 6 (Xinhua) -- Cuban medical authorities have launched the sales of the world's first therapeutic vaccine against lung cancer, local officials said on Tuesday.The CimaVax-EGF vaccine, as a result of a 25-year research into diseases related to tobacco smoking, has been developed by researchers and scientists at the Center of Molecular Immunology (CIM) in Havana.The active drug ingredient in the vaccine is based on "a protein we all have when cancer is uncontrolled." "The epidermal growth factor is related to all cell proliferation," said Gisela Gonzalez, head researcher of the project."The drug could turn the cancer into a manageable, chronic disease by generating antibodies against the proteins which triggered the uncontrolled cell proliferation," she said.The immunogenic vaccine is appropriate to patients with advanced lung cancer in stages of three and four, showing no positive response to other kinds of treatments such as chemotherapy and radiotherapy, the expert said."It is not possible to prevent the disease but this vaccine improves significantly the status of the critically ill patients," she added.She said the CimaVax-EGF has gone through clinical studies and trials in over 1,000 patients across the island and is currently distributed free of charge in all hospitals of the Caribbean island nation.Gonzalez also said researchers at the CIM planned to use the same principle of the CimaVax-EGF in treating other cancerous tumors such as prostate, uterus and breast cancers.Lung cancer is regarded as one of the world's most serious, common and deadly cancers and is most frequently found among tobacco smokers.According to the World Health Organization, the disease generally kills 5 million people a year, and the figure is expected to rise to as much as 8 million by 2030 unless smoking habits are changed.In Cuba, like many other developing countries across the world, smoking is seen as a status symbol. Lung cancer, killing about 20,000 people a year in the Caribbean country, is considered a serious threat to public health and the leading cause of death in 12 of the country's 15 provinces.
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