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A Seattle woman rinsed her sinuses with tap water. A year later, she died of a brain-eating amoeba.Her case is reported this week in the International Journal of Infectious Diseases.The 69-year-old, whose name was not given, had a lingering sinus infection. For a month, she tried to get rid of it using a neti pot with tap water instead of using sterile water, as is recommended.Neti pots are used to pour saline into one nostril and out of the other to irrigate the sinuses, usually to fight allergies or infections.According to the doctors who treated the woman, the non-sterile water that she used it thought to have contained Balamuthia mandrillaris, ?an amoeba that over the course of weeks to months can cause a very rare and almost always fatal infection in the brain.Once in her body, the amoeba slowly went about its deadly work.First, she developed a raised, red sore on the bridge of her nose. Doctors thought it was a rash and prescribed an antibiotic ointment, but that provided no relief. Over the course of a year, dermatologists hunted for a diagnosis.Then, the left side of the woman's body started shaking. She'd experienced a seizure that weakened her left arm. A CT scan showed an abnormal lesion in her brain that indicated she might have a tumor, so doctors sent a sample of tissue for testing.Over the next several days, additional scans revealed that whatever was happening in her brain was getting worse. The mass was growing, and new lesions were starting to show up.Finally, a neurosurgeon at Swedish Medical Center, where the woman was being treated, opened her skull to examine her brain and found that it was infected with amoebae.The US Centers for Disease Control and Prevention rushed the anti-amoeba drug miltefosine to Seattle to try to save the woman's life, but she fell into a coma and died.According to the CDC, most cases of Balamuthia mandrillaris aren't diagnosed until immediately before death or after death, so doctors don't have a lot of experience treating the amoeba and know little about how a person becomes infected.The amoeba was discovered in 1986. Since 1993, the CDC says, there have been at least 70 cases in the United States.As in the Seattle woman's case, the infections are "almost uniformly fatal," with a death rate of more than 89%, according to the doctors who treated her and the CDC.The amoeba is similar to Naegleria fowleri, which has been the culprit in several high-profile cases.In 2011, Louisiana health officials warned residents not to use nonsterilized tap water in neti pots after the deaths of two people who were exposed to Naegleria fowleri while flushing their nasal passages. An official urged users to fill the pots only with distilled, sterile or previously boiled water, and to rinse and dry them after each use."Improper nasal irrigation has been reported as a method of infection for the comparably insidious amoeba," the doctors say in the research paper about the Seattle woman. "This precedent led us to suspect the same route of entry for the ... amoeba in our case."The woman's doctors say they weren't able to definitely link the infection to her neti pot, as the water supply to her home was not tested for the amoeba. They hope her case will let other doctors know to consider an amoeba infection if a patient gets a sore or rash on the nose after rinsing their sinuses.Kristen Maki, a spokeswoman for the Washington State Department of Health, said in an email that "Large municipal water supplies ... have robust source water protection programs" and treatment programs, and she noted that "Well protected groundwater supplies are logically expected to be free of any such large amoeba" such as Balamuthia. 3746

A man wanted in connection with a quadruple murder in Detroit has shot himself, according to police. George Anthony Davis, 27, shot himself near the Ohio Turnpike after leading police on a chase.Police said Davis shot and killed three people, a man and two women, at a gas station iin Detroit Monday morning. The male victim was identified as Deacon Ralphael Hall, leader at a local church, his 26-year-old daughter Cierra Bargineer and 21-year-old Kristen Thomas.Police say surveillance cameras captured everything; a man pulled up in a silver sedan and started talking to people in a gray Dodge SUV. Seconds later, the man in the sedan shot the people in the SUV and shot at the man pumping gas.When he ran out of bullets, he went back to his car to reload, and came back to shoot more. Police say Bargineer was the mother of his child.Second Shooting LocationHe then gets in the car and goes to Faust Street and has a conversation with an adult male cousin and fatally shoots him, police said.  The suspect then goes to a gas station on Faust and takes a 2007 blue Nissan Ultima.Davis was on the run for several hours before police confirmed that he shot himself. Police said he's in critical condition.  1250

A potentially catastrophic Category 4 Hurricane Michael has made landfall as the strongest hurricane to hit the Florida Panhandle in recorded history, with its winds and storm surge wreaking havoc along the shore.Michael's extremely dangerous center crossed near Florida's Mexico Beach on Wednesday afternoon with sustained winds of 155 mph, the National Hurricane Center said.Photos: Hurricane Michael to slam US coastEarlier, Gov. Rick Scott called Michael "the worst storm that our Florida Panhandle has seen in a century."Streets were flooding in the Panhandle city of Apalachicola. In Panama City Beach, winds of about 100 mph furiously whipped the trees in the early afternoon as siding ripped from a building got caught against a fence.Earlier in that oceanside city, video from a meteorologist showed new construction collapsing in high winds.Among the concerns: Flash-flooding with heavy rain; life-threatening storm surges up to 14 feet high; and devastating winds, not just in the Panhandle, but southern Alabama and Georgia. 1044

A request from children is changing the future of LEGO kits. The company announced they will be phasing out their single-use plastic bags used to separate parts of their kits beginning next year.“We have received many letters from children about the environment asking us to remove single-use plastic packaging. We have been exploring alternatives for some time and the passion and ideas from children inspired us to begin to make the change,” stated CEO Niels Christiansen in a company release.The toymaker has set a goal of making all of their packaging sustainable by the end of 2025. Beginning in 2021, they will look at using recyclable paper bags in their kits.Testing has already taken place, and LEGO says kids liked the paper bags because they were environmentally friendly and easy to open.Other LEGO products will be getting an environmentally friendly makeover in the future, too. The company said it is testing blocks made from sugar cane and other sustainable materials. 992

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