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WASHINGTON, March 22 (Xinhua) -- A long-term study by Greek researchers has shown the effectiveness of replacing bone marrow, purposely destroyed by chemotherapy, with autologous (self) stem cells in treating people with aggressive forms of multiple sclerosis (MS).The study was published on Tuesday in Neurology, the medical journal of the American Academy of Neurology.For the treatment, chemotherapy drugs are used to kill all of the patient's blood cells, including the immune cells that are believed to be attacking the body's own central nervous system. Bone marrow stem cells removed from the patient are purified and transplanted back into the body, which saves life by replacing the blood cells and also is proposed to "reboot" the immune system.A human embryonic stem cell line derived at Stanford University is seen in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The study followed 35 people for an average of 11 years after transplant. The study involved people with rapidly progressive MS who had tried a number of other treatments for MS with little or no effect. All were severely disabled by the disease, with an average score of six on a scale of disease activity that ranges from zero being a normal neurological examination to 10 meaning death due to MS.A score of six means able to walk with a cane or crutch; a seven is mainly in a wheelchair. All had worsened by at least one point on the scale in the year prior to the transplant.After the transplants, the probability of participants having no worsening of their disease for 15 years was 25 percent. The probability was higher -- 44 percent -- for those who had active brain lesions, which are a sign of disease activity, at the time of the transplant.For 16 people, symptoms improved by an average of one point on the scale after the transplant, and the improvements lasted for an average of two years. The participants also had a reduction in the number and size of lesions in their brains. Two people (six percent) died from complications related to the transplant at two months and 2-1/2 years post-transplant.Study author Vasilios Kimiskidis, of Aristotle University in Thessaloniki, Greece, noted that more research is needed on this treatment, including studies that compare people receiving the treatment to a control group that does not receive the treatment."Keeping that in mind, our feeling is that stem cell transplants may benefit people with rapidly progressive MS," he said. "This is not a therapy for the general population of people with MS but should be reserved for aggressive cases that are still in the inflammatory phase of the disease."
BRASILIA, April 26 (Xinhua) -- A survey conducted by Brazil's Ministry of Health showed Tuesday that half of Brazilians aged over 55 have hypertension.According to the research, which has been carried out annually since 2006, the proportion of Brazilians diagnosed with hypertension increased over the past five years, from 21.6 percent in 2006 to 23.3 percent in 2010.Besides, the diagnosis of hypertension is higher among women (25.5 percent) than men (20.7 percent). But in both sexes, the older people are, the more common the disease becomes, the ministry reported.The ministry also said that, to address the problem, the Brazilian government distributes free medicines to control blood pressure, since 80 percent of Brazilians who suffer from hypertension depend on the public health system.The Ministry of Health signed on April 7 an agreement with the food industry, aiming to reduce salt in processed food.If hypertension is left untreated, some complications including clogged arteries, stroke and myocardial infarction will bring patients more troubles.
LOS ANGELES, April 17 (Xinhua) -- Global warming will melt all the ice in the Arctic Ocean every summer, raising earth temperatures even further, researchers at the University of California-Los Angeles (UCLA) warned.The findings, available online Sunday in the April issue of Earth and Planetary Science Letters, a leading journal in geoscience, were based on analysis of the fossilized remains of four-million-year-old mollusks, they said.Two novel geochemical techniques used to determine the temperature at which the mollusk shells were formed suggest that summertime Arctic temperatures during the early Pliocene epoch (3.5 million to 4 million years ago) may have been a staggering 18 to 28 degrees Fahrenheit warmer than today, the researchers said.And these ancient fossils, harvested from deep within the Arctic Circle, may have once lived in an environment in which the polar ice cap melted completely during the summer months, according to the researchers.Such balmy polar weather would certainly melt all the ice in the Arctic Ocean every summer, said Aradhna Tripani, an assistant professor at the UCLA's departments of Earth and space sciences."Our data from the early Pliocene, when carbon dioxide levels remained close to modern levels for thousands of years, may indicate how warm the planet will eventually become if carbon dioxide levels are stabilized at the current value of 400 parts per million," she said.The earth's temperature was raised five to nine degrees Fahrenheit merely by the absence of year-round Arctic ice, according to Tripani.The results of the study lend support to assertions made by climate modelers that summertime sea ice may be eliminated in the next 50 to 100 years, which would have far-reaching consequences for Earth's climate, she said."The Intergovernmental Panel on Climate Change identifies the early Pliocene as the best geological analog for climate change in the 21st century and beyond," said Tripati. "The climate-modeling community hopes to use the early Pliocene as a benchmark for testing models used for forecasting future climate change."
BEIJING, Jan. 25 (Xinhua) -- A senior Chinese official has encouraged the country's young jurists to more actively participate in the country's legislative process and better serve the practice of law enforcement.Zhou Yongkang, a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, made the remarks in meeting with outstanding youth law science experts on Tuesday in Beijing.Zhou said young experts on law science should pay more attention to practical problems in China's legal construction and propose more insights, advice and suggestions.Young experts should study more problems encountered by common people and better serve the people with their knowledge, Zhou said.Ten experts on law science from the Renmin University of China, China University of Political Science and Law and other universities and Chinese Academy of Social Sciences were awarded the honor of national outstanding young jurists by the China Law Society.
WASHINGTON, April 25 (Xinhua) -- Study by scientists at the Rockefeller University shows that anti-inflammatory drugs reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors (SSRIs), taken for depression and obsessive-compulsive disorder and anxiety disorders.This discovery, published online Monday in the Proceedings of the National Academy of Sciences, may explain why so many depressed patients taking SSRIs do not respond to antidepressant treatment and suggests that this lack of effectiveness may be preventable.The study may be especially significant in the case of Alzheimer's disease. Such patients commonly suffer from depression and unless this can be treated successfully, the course of the illness is likely to be more severe. Depression in the elderly is also a risk factor for developing Alzheimer's Disease and researchers have suggested that treating depression in the elderly might reduce the risk of developing the disease.In the recent study, investigators treated mice with antidepressants in the presence or absence of anti-inflammatory drugs. They then examined how the mice behaved in tasks that are sensitive to antidepressant treatment. They found that the mice's behavioral responses to antidepressants were inhibited by anti- inflammatory/analgesic treatments.They then confirmed these effects in a human population. Depressed individuals who reported anti-inflammatory drug use were much less likely to have their symptoms relieved by an antidepressant than depressed patients who reported no anti- inflammatory drug use. The effect was rather dramatic since, in the absence of any anti-inflammatory or analgesic use, 54 percent of patients responded to the antidepressant, whereas success rates dropped to approximately 40 percent for those who reported using anti-inflammatory agents."Many elderly individuals suffering from depression also have arthritic or related diseases and as a consequence are taking both antidepressant and anti-inflammatory medications. Our results suggest that physicians should carefully balance the advantages and disadvantages of continuing anti-inflammatory therapy in patients being treated with antidepressant medications," leader author Paul Greengard said.