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WASHINGTON, April 11 (Xinhua) -- In the first clinical trial of gene therapy for treatment of intractable pain, U.S. researchers from the University of Michigan's Department of Neurology observed that the treatment appears to be able to provide substantial pain relief.In a study published online in the Annals of Neurology and seen on Monday, the researchers showed that the novel agent NP2 is safe and well-tolerated. In addition, measures of pain in the treated patients suggested that NP2 may provide a substantial analgesic effect.NP2 is a gene transfer vector that expresses the naturally- occurring opioid peptide enkephalin. In preclinical work in animals, David Fink, chair of the Department of Neurology, and his coworkers had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation or cancer.In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain."The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," says Fink. "In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of four weeks following treatment."Fink's laboratory has been working on the use of modified herpes simplex virus-based vectors that are taken up by sensory nerves following skin injection to develop therapies for diseases of the nervous system for more than 20 years. Patents related to this technology have been exclusively licensed by Diamyd Medical, a publicly-traded Swedish biotechnology company that sponsored the trial, and the human-grade vector NP2 was produced by Diamyd, Inc, the U.S. subsidiary of Diamyd Medical.A phase 2 trial to compare NP2 to a placebo control has already been initiated under sponsorship from Diamyd.

BEIJING, March 21 (Xinhuanet) -- A new device is being developed by American engineers to ease pain of blood sugar testing in diabetics, according to foreign media report last week.The upcoming device is the research target of a team of engineers at Arizona State University. It is specifically designed for patients with type1diabetes and type2 diabetes, according to a report in the "Journal of Diabetes Science and Technology,"  The traditional method of testing blood sugar levels involves painful pricks on the fingers to draw blood for testing. The inconvenient and painful process may somehow leave diabetics lax in their testing. The blood sugar levels, when poorly controlled, are very likely to trigger complications including heart disease, kidney disease and retinopathy.Unlike the old testing method, the new device could help people keep track of their blood sugar levels without the need to break the skin. It draws tears to measures the blood sugar levels in the fluid and gives just an accurate reading of blood sugar levels. "This new technology might encourage patients to check their blood sugars more often, which could lead to better control of their diabetes by a simple touch to the eye." said Jeffrey T. LaBelle, developer of the device.The new testing device has drawn great interest from investors due to its promising prospects. However, it still awaits a significant amount of testing before it can hit the market.

PYONGYANG, Feb. 14 (Xinhua) -- Kim Yong Nam, president of the Presidium of the Supreme People's Assembly of the Democratic People's Republic of Korea (DPRK), met Chinese Minister of Public Security Meng Jianzhu here on Monday.Kim said it was the consistent stand of the Worker's Party of Korea (WPK) and the government and the firm will of the people to develop the traditional DPRK-China friendship generation after generation.The DPRK is sincerely happy to see the great achievement China has made and wish that the Chinese people make even more progress, Kim said.Meng, also a State Councilor, said the traditional friendship between the two neighboring countries has strengthened through the ages. He expressed his expectations of inheriting the friendship, deepening communications and cooperation in various areas and promoting the China-DPRK friendship.Ri Yong Ho, Presidium of Political Bureau of Central Committee of WPK and chief of the Korean People's Army General Staff, also met Meng on the same day.Ju Sang Song, a member of the Political Bureau of Central Committee of the WPK and Minister of People's Security, met Meng on Sunday. The two achieved consensus on making more efforts to develop cooperation and communications on public security to make active contributions to the traditional China-DPRK friendship. An agreement on cooperation between the the two security ministries was signed after the meeting.Meng arrived at Pyongyang on Sunday at the invitation of Ju Sang Song.

LOS ANGELES, April 4 (Xinhua) -- A woman's breast milk cells may be used to predict cancer in future research, according to a study published by HealthDay News on Monday.In the study, researchers at the University of Massachusetts in Amherst collected breast milk from 271 women in the United States. All had either undergone a biopsy of the breast to check for cancer, or were scheduled for one.The researchers evaluated breast milk samples from the biopsied and non-biopsied breasts.The researchers first isolated potentially cancerous cells, known as epithelial cells, and then isolated DNA to look for signals that regulate tumor suppresser genes.In the next step, the researchers analyzed three genes among the many known to undergo a process called methylation in breast cancer. Methylation in a specific region of a gene can inhibit or suppress the expression of a gene.For one gene, SFRP1, the average methylation was higher in the biopsied breast, the study found.Among the women whose biopsies detected cancer, average methylation of the RASSF1 gene in the biopsied breast was considerably higher compared to the non-biopsied breast.Among the women whose biopsies detected cancer, average methylation of the RASSF1 gene in the biopsied breast was considerably higher compared to the non-biopsied breast."It looks as if we can use the cells from breast milk to assess breast cancer risk," said Dr. Kathleen Arcaro, an associate professor of veterinary and animal sciences at the university.It's too soon, however, to assess the cancer detection rate associated with breast milk cell examination, she said."We can't say at this point for two reasons," she said. "One is, we need long-term follow-up. And the second really important reason is, we need to sample a larger panel of genes."Arcaro is to present her findings later Monday at the annual meeting of the American Association for Cancer Research in Orlando, Florida, according to HealthDay News.

BEIJING, Feb. 10 (Xinhua) -- More than 9,300 kidnapped children in China have been rescued since April 2009 since a nationwide campaign was launched to crack down on human trafficking, according to the Ministry of Public Security Thursday.In a statement, the ministry encouraged the involvement of civilians in providing clues to help the police rescue minors -- especially those being abused and forced to beg on the streets.In less than three weeks, a Chinese microblog called "Street Photos to Rescue Child Beggars" attracted 175,000 followers and posted more than 2,500 images of begging children online for parents to identify.The blog was set up last month by a professor with the Rural Development Institute of the Beijing-based China Academy of Social Sciences. It has helped rescue six children so far.However, the ministry noted in the statement that children kidnapped to become beggars took up only a small portion of all cases of child beggars. In most cases, children were taken to beg along with their parents or relatives.The ministry has urged police authorities across the country to closely cooperate with civil affairs, urban management and health departments in apprehending people who force children to become beggars.